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Gene Review

Mmp1  -  Matrix metalloproteinase 1

Drosophila melanogaster

Synonyms: CG4859, Dm1-MMP, Dmel\CG4859, MMP-1, MMP1, ...
 
 
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Disease relevance of Mmp1

 

High impact information on Mmp1

 

Biological context of Mmp1

  • We created mutations in both genes: Mmp1 mutants have defects in larval tracheal growth and pupal head eversion, and Mmp2 mutants have defects in larval tissue histolysis and epithelial fusion during metamorphosis; neither is required for embryonic development [5].
 

Analytical, diagnostic and therapeutic context of Mmp1

  • Northern blot analysis of Dm1-MMP expression in embryonic and larval adult tissues revealed a strong expression level in the developing embryo at 10-22 h, declining thereafter and being undetectable in adults [1].
  • Western blot analysis confirmed the presence of pro- and active forms of Dm1-MMP in vivo during larval development [1].

References

  1. Dm1-MMP, a matrix metalloproteinase from Drosophila with a potential role in extracellular matrix remodeling during neural development. Llano, E., Pendás, A.M., Aza-Blanc, P., Kornberg, T.B., López-Otín, C. J. Biol. Chem. (2000) [Pubmed]
  2. Involvement of histone deacetylation in ras-induced down-regulation of the metastasis suppressor RECK. Chang, H.C., Liu, L.T., Hung, W.C. Cell. Signal. (2004) [Pubmed]
  3. An MMP liberates the Ninjurin A ectodomain to signal a loss of cell adhesion. Zhang, S., Dailey, G.M., Kwan, E., Glasheen, B.M., Sroga, G.E., Page-McCaw, A. Genes Dev. (2006) [Pubmed]
  4. Structural and enzymatic characterization of Drosophila Dm2-MMP, a membrane-bound matrix metalloproteinase with tissue-specific expression. Llano, E., Adam, G., Pendás, A.M., Quesada, V., Sánchez, L.M., Santamariá, I., Noselli, S., López-Otín, C. J. Biol. Chem. (2002) [Pubmed]
  5. Drosophila matrix metalloproteinases are required for tissue remodeling, but not embryonic development. Page-McCaw, A., Serano, J., Santé, J.M., Rubin, G.M. Dev. Cell (2003) [Pubmed]
 
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