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Gene Review

Reck  -  reversion-inducing-cysteine-rich protein...

Mus musculus

Synonyms: Reversion-inducing cysteine-rich protein with Kazal motifs, St15, mRECK
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Disease relevance of Reck


High impact information on Reck


Chemical compound and disease context of Reck

  • The RECK gene was initially isolated as a transformation suppressor gene encoding a novel membrane-anchored glycoprotein and later found to suppress tumor invasion and metastasis by regulating matrix metalloproteinase-9 [7].

Biological context of Reck


Anatomical context of Reck

  • In the present study, we have found that in later stage wild-type embryos, RECK is abundantly expressed in skeletal muscles, especially in the areas where the myoblast differentiation factor MRF4 is expressed [1].
  • Myoblastic cells lacking RECK expression give rise to myotubes at higher efficiency than the cells expressing RECK, indicating that RECK suppresses myotube formation [1].
  • We profiled the RNA levels of every MMP, several ADAMs, and inhibitors of metalloproteinases (TIMPs and RECK) in numerous mouse tissues during development and in the uterus during pregnancy [9].
  • Mice lacking RECK die in utero with reduced integrity of blood vessels, the neural tube, and mesenchymal tissues [10].

Associations of Reck with chemical compounds


Regulatory relationships of Reck

  • So, we tested whether ras activation induced the binding of histone deacetylases (HDACs) to Sp1 to repress RECK expression [11].
  • The signaling pathway by which ras suppresses RECK was also addressed [11].

Other interactions of Reck

  • Co-transfection assay showed that Sp1 and Sp3 are transactivators, rather than repressors, for RECK gene [11].
  • Addition of PD98059 or overexpression of dominant-negative mutant of ERK2 indeed reversed ras-mediated inhibition of RECK promoter activity [11].

Analytical, diagnostic and therapeutic context of Reck

  • When the same doses of THP and ADM were administered intraperitoneally to nude mice bearing St-15, St-40 and SC-1-NU, the antitumor activity of THP was almost equivalent to ADM in terms of relative mean tumor weight [12].


  1. The membrane-anchored MMP-regulator RECK is a target of myogenic regulatory factors. Echizenya, M., Kondo, S., Takahashi, R., Oh, J., Kawashima, S., Kitayama, H., Takahashi, C., Noda, M. Oncogene (2005) [Pubmed]
  2. Antitumor activity of a novel antitumor antibiotic, quinocarmycin citrate (KW2152). Fujimoto, K., Oka, T., Morimoto, M. Cancer Res. (1987) [Pubmed]
  3. Effects of gastrin on tumor growth and cyclic nucleotide metabolism in xenotransplantable human gastric and colonic carcinomas in nude mice. Sumiyoshi, H., Yasui, W., Ochiai, A., Tahara, E. Cancer Res. (1984) [Pubmed]
  4. Inhibition of the growth of various human and mouse tumor cells by 1,15-bis(ethylamino)-4,8,12-triazapentadecane. Igarashi, K., Koga, K., He, Y., Shimogori, T., Ekimoto, H., Kashiwagi, K., Shirahata, A. Cancer Res. (1995) [Pubmed]
  5. Combined effect of 5-fluorouracil and carboplatin against human gastric cancer cell lines in vitro and in vivo. Saikawa, Y., Kubota, T., Kuo, T.H., Tanino, H., Kase, S., Furukawa, T., Watanabe, M., Ishibiki, K., Kitajima, M., Hoffman, R.M. Anticancer Res. (1994) [Pubmed]
  6. Type I and II cyclic adenosine 3':5'-monophosphate-dependent protein kinase in human gastric mucosa and carcinomas. Yasui, W., Sumiyoshi, H., Ochiai, A., Yamahara, M., Tahara, E. Cancer Res. (1985) [Pubmed]
  7. Oncogene-mediated downregulation of RECK, a novel transformation suppressor gene. Sasahara, R.M., Takahashi, C., Sogayar, M.C., Noda, M. Braz. J. Med. Biol. Res. (1999) [Pubmed]
  8. Involvement of the Sp1 site in ras-mediated downregulation of the RECK metastasis suppressor gene. Sasahara, R.M., Takahashi, C., Noda, M. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  9. Expression analysis of the entire MMP and TIMP gene families during mouse tissue development. Nuttall, R.K., Sampieri, C.L., Pennington, C.J., Gill, S.E., Schultz, G.A., Edwards, D.R. FEBS Lett. (2004) [Pubmed]
  10. RECK: a novel suppressor of malignancy linking oncogenic signaling to extracellular matrix remodeling. Noda, M., Oh, J., Takahashi, R., Kondo, S., Kitayama, H., Takahashi, C. Cancer Metastasis Rev. (2003) [Pubmed]
  11. Involvement of histone deacetylation in ras-induced down-regulation of the metastasis suppressor RECK. Chang, H.C., Liu, L.T., Hung, W.C. Cell. Signal. (2004) [Pubmed]
  12. Antitumor activity of (2''R)-4'-O-tetrahydropyranyl adriamycin on human gastric cancer cell lines in vitro and in vivo. Saikawa, Y., Kubota, T., Kuo, T.H., Furukawa, T., Kase, S., Tanino, H., Ishibiki, K., Kitajima, M., Hoffman, R.M. Anticancer Res. (1994) [Pubmed]
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