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Gene Review

KIR3DL2  -  killer cell immunoglobulin-like receptor,...

Homo sapiens

Synonyms: CD158 antigen-like family member K, CD158K, Killer cell immunoglobulin-like receptor 3DL2, MHC class I NK cell receptor, NKAT-4, ...
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Disease relevance of KIR3DL2


High impact information on KIR3DL2


Biological context of KIR3DL2

  • Strikingly, both the lytic and the cytokine secretion activities induced upon specific cell interactions were unaffected by anti-KIR3DL2/p140 antibody [9].
  • Single amino acid substitutions in the nonamer peptide underline a critical role for residue 8 in recognition of KIR3DL2 [10].
  • We observed 18 different genotypes and eight KIR3DL2 alleles in the population, with KIR3DL2*002 having the highest frequency of 0.558, and confirmed the new KIR3DL2*015 allele [11].
  • Additionally, the KIR3DL2 allele status of cell line DNA and Centre d'Etude du Polymorphisme Humain (CEPH) families, both from the 13th International Histocompatibility Workshop, has been established [12].
  • Our data showed that the established PCR-SBT methods for KIR3DL2 allele typing were reliable, and Chinese Han population is distinct in KIR3DL2 allele frequencies [11].

Anatomical context of KIR3DL2

  • Alternatively, KIR3DL2 was detected on TALL-104, and expression of its reported ligand, human leukocyte antigen (HLA)-A, on target cells provided protection from cytotoxicity [13].
  • In contrast, MEP decreased tumor suppressor Rb mRNA in CL5 lung epithelial cells [4].
  • Incubation of human lung fibroblast WI-38 with MEP- or benzo(a)pyrene-induced CL5 conditioned medium for 4 days stimulated cell growth of the fibroblasts [4].
  • Analysis of the CGD samples by immunoblotting indicated that CL5 recognizes only the full-length wild-type and two missense mutations, consistent with the absence of stable short gp91phox peptide expression in CGD neutrophils [14].
  • The presence of microvilli can be controlled as a function of temperature by two temperature-sensitive mutants of the Kirsten sarcoma virus (ts6t6 and ts371 cl 5) [15].

Other interactions of KIR3DL2

  • Extension of this comparative analysis to include all 12 KIR family members showed that KIR2DL3 and KIR3DL2 were the only genes whose transcripts were consistently detectable [16].

Analytical, diagnostic and therapeutic context of KIR3DL2

  • 2. Sequence analysis indicated that KIR3DL2/p140 cDNA was identical to the previously reported 3DL2*002 allele except for two nucleic acid substitutions [9].


  1. Killer cell immunoglobulin-like receptor expression delineates in situ Sézary syndrome lymphocytes. Wechsler, J., Bagot, M., Nikolova, M., Parolini, S., Martin-Garcia, N., Boumsell, L., Moretta, A., Bensussan, A. J. Pathol. (2003) [Pubmed]
  2. CD158k/KIR3DL2 is a new phenotypic marker of Sezary cells: relevance for the diagnosis and follow-up of Sezary syndrome. Poszepczynska-Guigné, E., Schiavon, V., D'Incan, M., Echchakir, H., Musette, P., Ortonne, N., Boumsell, L., Moretta, A., Bensussan, A., Bagot, M. J. Invest. Dermatol. (2004) [Pubmed]
  3. Growth of human hepatoma cells lines with differentiated functions in chemically defined medium. Nakabayashi, H., Taketa, K., Miyano, K., Yamane, T., Sato, J. Cancer Res. (1982) [Pubmed]
  4. Induction of fibroblast growth factor-9 and interleukin-1alpha gene expression by motorcycle exhaust particulate extracts and benzo(a)pyrene in human lung adenocarcinoma cells. Ueng, T.H., Hung, C.C., Kuo, M.L., Chan, P.K., Hu, S.H., Yang, P.C., Chang, L.W. Toxicol. Sci. (2005) [Pubmed]
  5. Polymorphic expression of CD158k/p140/KIR3DL2 in Sézary patients. Musette, P., Michel, L., Jean-Louis, F., Bagot, M., Bensussan, A. Blood (2003) [Pubmed]
  6. Engagement of ILT2/CD85j in Sézary syndrome cells inhibits their CD3/TCR signaling. Nikolova, M., Musette, P., Bagot, M., Boumsell, L., Bensussan, A. Blood (2002) [Pubmed]
  7. Formation of the killer Ig-like receptor repertoire on CD4+CD28null T cells. Snyder, M.R., Muegge, L.O., Offord, C., O'Fallon, W.M., Bajzer, Z., Weyand, C.M., Goronzy, J.J. J. Immunol. (2002) [Pubmed]
  8. Different NK cell surface phenotypes defined by the DX9 antibody are due to KIR3DL1 gene polymorphism. Gardiner, C.M., Guethlein, L.A., Shilling, H.G., Pando, M., Carr, W.H., Rajalingam, R., Vilches, C., Parham, P. J. Immunol. (2001) [Pubmed]
  9. Functional and molecular characterization of a KIR3DL2/p140 expressing tumor-specific cytotoxic T lymphocyte clone infiltrating a human lung carcinoma. Dorothée, G., Echchakir, H., Le Maux Chansac, B., Vergnon, I., El Hage, F., Moretta, A., Bensussan, A., Chouaib, S., Mami-Chouaib, F. Oncogene (2003) [Pubmed]
  10. Recognition of HLA-A3 and HLA-A11 by KIR3DL2 is peptide-specific. Hansasuta, P., Dong, T., Thananchai, H., Weekes, M., Willberg, C., Aldemir, H., Rowland-Jones, S., Braud, V.M. Eur. J. Immunol. (2004) [Pubmed]
  11. Investigation of killer cell immunoglobulin-like receptors gene KIR3DL2 diversity and confirmation of KIR3DL2*015 in a Chinese population. Yan, L.X., Zhu, F.M., Jiang, K., Lv, Q.F., He, J.J. Tissue Antigens (2006) [Pubmed]
  12. Investigation of killer cell immunoglobulin-like receptor gene diversity V. KIR3DL2. Meenagh, A., Williams, F., Sleator, C., Halfpenny, I.A., Middleton, D. Tissue Antigens (2004) [Pubmed]
  13. Receptors and lytic mediators regulating anti-tumor activity by the leukemic killer T cell line TALL-104. Brando, C., Mukhopadhyay, S., Kovacs, E., Medina, R., Patel, P., Catina, T.L., Campbell, K.S., Santoli, D. J. Leukoc. Biol. (2005) [Pubmed]
  14. Monoclonal antibody CL5 recognizes the amino terminal domain of human phagocyte flavocytochrome b558 large subunit, gp91phox. Baniulis, D., Burritt, J.B., Taylor, R.M., Dinauer, M.C., Heyworth, P.G., Parkos, C.A., Magnusson, K.E., Jesaitis, A.J. Eur. J. Haematol. (2005) [Pubmed]
  15. The correlation of plasma membrane microvilli and intracellular cyclic AMP content in a rat epitheloid kidney cell line. Carley, W.W., Moses, H.L., Mitchell, W.M. J. Supramol. Struct. (1976) [Pubmed]
  16. Comparison of killer Ig-like receptor genotyping and phenotyping for selection of allogeneic blood stem cell donors. Leung, W., Iyengar, R., Triplett, B., Turner, V., Behm, F.G., Holladay, M.S., Houston, J., Handgretinger, R. J. Immunol. (2005) [Pubmed]
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