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Gene Review

RAD51  -  RAD51 recombinase

Gallus gallus

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High impact information on RAD51

  • Although recent evidence supports at least Xrcc3 and Rad51C playing a role late in HR, our data suggest that Brca2 and the Rad51 paralogs may also contribute to HR at the same early step, with their loss resulting in the stimulation of an alternative, error-prone repair pathway [1].
  • In contrast to these defects, we also found increased spontaneous sister chromatid exchange (SCE) and intact Rad51 foci formation after DNA damage [2].
  • However, caffeine has a much smaller radiosensitizing effect on RAD54(-/-) cells and has no effect on RAD51-deficient cells [3].
  • RAD51 levels were three times higher in appendix B lymphocytes compared with T lymphocytes and were lower in adult appendix, as well as in spleen and Peyer's patches of young rabbits [4].
  • Using a quantitative polymerase chain reaction mimic assay and conventional northern analyses, we found high RAD51 expression in young rabbit appendix comparable to levels in testis where there is an abundance of meiotic recombination [4].

Biological context of RAD51


  1. Similar effects of Brca2 truncation and Rad51 paralog deficiency on immunoglobulin V gene diversification in DT40 cells support an early role for Rad51 paralogs in homologous recombination. Hatanaka, A., Yamazoe, M., Sale, J.E., Takata, M., Yamamoto, K., Kitao, H., Sonoda, E., Kikuchi, K., Yonetani, Y., Takeda, S. Mol. Cell. Biol. (2005) [Pubmed]
  2. Fanconi anemia protein FANCD2 promotes immunoglobulin gene conversion and DNA repair through a mechanism related to homologous recombination. Yamamoto, K., Hirano, S., Ishiai, M., Morishima, K., Kitao, H., Namikoshi, K., Kimura, M., Matsushita, N., Arakawa, H., Buerstedde, J.M., Komatsu, K., Thompson, L.H., Takata, M. Mol. Cell. Biol. (2005) [Pubmed]
  3. Caffeine could not efficiently sensitize homologous recombination repair-deficient cells to ionizing radiation-induced killing. Wang, H., Wang, X., Iliakis, G., Wang, Y. Radiat. Res. (2003) [Pubmed]
  4. High RAD51 mRNA levels in young rabbit appendix. A role in B-cell gene conversion? Schiaffella, E., Fuschiotti, P., Bensinger, S.J., Mage, R.G. Immunogenetics (1998) [Pubmed]
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