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Gene Review

spn-A  -  spindle A

Drosophila melanogaster

Synonyms: CG7948, D37788, DMR, DMR/DroRAD51, DMR1, ...
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Disease relevance of spn-A


High impact information on spn-A

  • Strand pairing by Rad54 and Rad51 is enhanced by chromatin [2].
  • Rad54 is related to the ATPase subunits of chromatin-remodeling factors, whereas Rad51 is related to bacterial RecA [2].
  • Our study further demonstrates that in Drosophila the Rad51-dependent homologous recombination pathway is not essential for DNA repair in the soma, unless exposed to DNA damaging agents [3].
  • Yeast Rad51 mutants are viable but show meiosis defects [3].
  • We therefore propose that under normal conditions a second, Rad51-independent, repair pathway prevents the lethal effects of DNA damage [3].

Biological context of spn-A


Anatomical context of spn-A

  • Rad51 is a conserved protein essential for recombinational repair of double-stranded DNA breaks (DSBs) in somatic cells and during meiosis in germ cells [3].
  • SpnA is also shown to interact with meiotic chromosomes during prophase I in the primary spermatocytes of hsp26-spnA transgenic flies [5].

Other interactions of spn-A

  • Epistasis experiments suggest that REC acts after the Rad51 ortholog SPN-A but before the endonuclease MEI-9 [6].


  1. Functional analysis of the Drosophila Rad51 gene (spn-A) in repair of DNA damage and meiotic chromosome segregation. Yoo, S., McKee, B.D. DNA Repair (Amst.) (2005) [Pubmed]
  2. Strand pairing by Rad54 and Rad51 is enhanced by chromatin. Alexiadis, V., Kadonaga, J.T. Genes Dev. (2002) [Pubmed]
  3. An essential role of DmRad51/SpnA in DNA repair and meiotic checkpoint control. Staeva-Vieira, E., Yoo, S., Lehmann, R. EMBO J. (2003) [Pubmed]
  4. Overexpression of Drosophila Rad51 protein (DmRad51) disrupts cell cycle progression and leads to apoptosis. Yoo, S., McKee, B.D. Chromosoma (2004) [Pubmed]
  5. Characterization of Drosophila Rad51/SpnA protein in DNA binding and embryonic development. Yoo, S. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  6. REC, Drosophila MCM8, drives formation of meiotic crossovers. Blanton, H.L., Radford, S.J., McMahan, S., Kearney, H.M., Ibrahim, J.G., Sekelsky, J. PLoS Genet. (2005) [Pubmed]
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