High impact information on ATRAD51

• Increases in recombination are accompanied by a strong induction of photolyase and Rad51 gene expression [1].
• These Rad51-like proteins are all members of the genetic recombination and DNA damage repair pathways [2].
• The sequenced genome of Arabidopsis thaliana encodes putative homologues of all six vertebrate Rad51-like proteins [2].
• Chromosome fragmentation is suppressed by atspo11-1, indicating that AtRAD51 functions downstream of AtSPO11-1 [3].
• The Arabidopsis AtRAD51 gene is dispensable for vegetative development but required for meiosis [3].

Biological context of ATRAD51

• Finally, a synchronisation experiment conducted with the suspension culture indicated that not only AtRAD51 but also AtDMC1 are regulated during the cell cycle, with S-phase-specific induction [4].
• Our studies reveal that the swi1-2 mutation prevents the formation of RAD51 foci during meiotic prophase and suppresses the chromosome fragmentation phenotype of the recombination-defective dif1-1 mutant [5].
• We have recently reported that the absence of AtXrcc3, an Arabidopsis Rad51 paralogue, leads to extensive chromosome fragmentation during meiosis, first visible in diplotene of meiotic prophase I [6].

Other interactions of ATRAD51

• We cloned two RAD51-like genes named AtXRCC3 and AtRAD51C from Arabidopsis thaliana [7].

Analytical, diagnostic and therapeutic context of ATRAD51

• Molecular cloning and characterization of RAD51-like genes from Arabidopsis thaliana [7].

References