Gene Review:
Ntrk2 - neurotrophic tyrosine kinase, receptor,...
Rattus norvegicus
Synonyms:
BDNF/NT-3 growth factors receptor, Neurotrophic tyrosine kinase receptor type 2, RATTRKB1, TRKB1, Tkrb, ...
Tan,
Shepherd,
Yamada,
Numakawa,
Koshimizu,
Tanabe,
Wada,
Koizumi,
Hatanaka,
Klintsova,
Dickson,
Yoshida,
Greenough,
Sakuma,
Watanabe,
Sano,
Uramoto,
Nakano,
Li,
Kaneda,
Sorimachi,
Yoshimoto,
Yasuhara,
Totsuka,
Miyata,
Omori,
Uchino,
Yamaguchi,
Isshiki,
Shibasaki,
Wahle,
Di Cristo,
Schwerdtfeger,
Engelhardt,
Berardi,
Maffei,
- Brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from chemotherapy-induced apoptosis via phosphatidylinositol 3'-kinase pathway. Jaboin, J., Kim, C.J., Kaplan, D.R., Thiele, C.J. Cancer Res. (2002)
- Changes in retinal expression of neurotrophins and neurotrophin receptors induced by ocular hypertension. Rudzinski, M., Wong, T.P., Saragovi, H.U. J. Neurobiol. (2004)
- Cellular levels of TrkB and MAPK in the neuroprotective role of BDNF for embryonic rat cortical neurons against hypoxia in vitro. Meng, M., Zhiling, W., Hui, Z., Shengfu, L., Dan, Y., Jiping, H. Int. J. Dev. Neurosci. (2005)
- Amygdala BDNF signaling is required for consolidation but not encoding of extinction. Chhatwal, J.P., Stanek-Rattiner, L., Davis, M., Ressler, K.J. Nat. Neurosci. (2006)
- Activity-dependent release of brain-derived neurotrophic factor underlies the neuroprotective effect of N-methyl-D-aspartate. Marini, A.M., Rabin, S.J., Lipsky, R.H., Mocchetti, I. J. Biol. Chem. (1998)
- Altered expression of BDNF and its high-affinity receptor TrkB in response to complex motor learning and moderate exercise. Klintsova, A.Y., Dickson, E., Yoshida, R., Greenough, W.T. Brain Res. (2004)
- Cyclic AMP controls BDNF-induced TrkB phosphorylation and dendritic spine formation in mature hippocampal neurons. Ji, Y., Pang, P.T., Feng, L., Lu, B. Nat. Neurosci. (2005)
- Truncated and full-length TrkB receptors regulate distinct modes of dendritic growth. Yacoubian, T.A., Lo, D.C. Nat. Neurosci. (2000)
- Synapsins as mediators of BDNF-enhanced neurotransmitter release. Jovanovic, J.N., Czernik, A.J., Fienberg, A.A., Greengard, P., Sihra, T.S. Nat. Neurosci. (2000)
- Hypothermic reperfusion after cardiac arrest augments brain-derived neurotrophic factor activation. D'Cruz, B.J., Fertig, K.C., Filiano, A.J., Hicks, S.D., DeFranco, D.B., Callaway, C.W. J. Cereb. Blood Flow Metab. (2002)
- Involvement of the brain-derived neurotrophic factor/TrkB pathway in neuroprotecive effect of cyclosporin A in forebrain ischemia. Miyata, K., Omori, N., Uchino, H., Yamaguchi, T., Isshiki, A., Shibasaki, F. Neuroscience (2001)
- Expression of p75NGFR TrkA, and TrkB mRNA in rat C6 glioma and type I astrocyte cultures. Hutton, L.A., deVellis, J., Perez-Polo, J.R. J. Neurosci. Res. (1992)
- Aminoglycoside-induced degeneration of adult spiral ganglion neurons involves differential modulation of tyrosine kinase B and p75 neurotrophin receptor signaling. Tan, J., Shepherd, R.K. Am. J. Pathol. (2006)
- Long-term potentiation in the dentate gyrus of the rat hippocampus is accompanied by brain-derived neurotrophic factor-induced activation of TrkB. Gooney, M., Lynch, M.A. J. Neurochem. (2001)
- BDNF down-regulates neurotrophin responsiveness, TrkB protein and TrkB mRNA levels in cultured rat hippocampal neurons. Frank, L., Ventimiglia, R., Anderson, K., Lindsay, R.M., Rudge, J.S. Eur. J. Neurosci. (1996)
- Pan-neurotrophin 1: a genetically engineered neurotrophic factor displaying multiple specificities in peripheral neurons in vitro and in vivo. Ilag, L.L., Curtis, R., Glass, D., Funakoshi, H., Tobkes, N.J., Ryan, T.E., Acheson, A., Lindsay, R.M., Persson, H., Yancopoulos, G.D. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Truncated TrkB receptor-induced outgrowth of dendritic filopodia involves the p75 neurotrophin receptor. Hartmann, M., Brigadski, T., Erdmann, K.S., Holtmann, B., Sendtner, M., Narz, F., Lessmann, V. J. Cell. Sci. (2004)
- Brain-derived neurotrophic factor rapidly enhances synaptic transmission in hippocampal neurons via postsynaptic tyrosine kinase receptors. Levine, E.S., Dreyfus, C.F., Black, I.B., Plummer, M.R. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Astrocytes in culture express the full-length Trk-B receptor and respond to brain derived neurotrophic factor by changing intracellular calcium levels: effect of ethanol exposure in rats. Climent, E., Sancho-Tello, M., Miñana, R., Barettino, D., Guerri, C. Neurosci. Lett. (2000)
- Distinct usages of phospholipase C gamma and Shc in intracellular signaling stimulated by neurotrophins. Yamada, M., Numakawa, T., Koshimizu, H., Tanabe, K., Wada, K., Koizumi, S., Hatanaka, H. Brain Res. (2002)
- Shp-2 specifically regulates several tyrosine-phosphorylated proteins in brain-derived neurotrophic factor signaling in cultured cerebral cortical neurons. Araki, T., Yamada, M., Ohnishi, H., Sano, S., Uetsuki, T., Hatanaka, H. J. Neurochem. (2000)
- Transcellular induction of neuropeptide Y expression by NT4 and BDNF. Wirth, M.J., Patz, S., Wahle, P. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Down-regulation of the neurotrophin receptor TrkB following ligand binding. Evidence for an involvement of the proteasome and differential regulation of TrkA and TrkB. Sommerfeld, M.T., Schweigreiter, R., Barde, Y.A., Hoppe, E. J. Biol. Chem. (2000)
- Involvement of BDNF receptor TrkB in spatial memory formation. Mizuno, M., Yamada, K., He, J., Nakajima, A., Nabeshima, T. Learn. Mem. (2003)
- A possible role for BDNF, NT-4 and TrkB in the spinal cord and muscle of rat subjected to mechanical overload, bupivacaine injection and axotomy. Sakuma, K., Watanabe, K., Sano, M., Uramoto, I., Nakano, H., Li, Y.J., Kaneda, S., Sorimachi, Y., Yoshimoto, K., Yasuhara, M., Totsuka, T. Brain Res. (2001)
- Identification of TrkB autophosphorylation sites and evidence that phospholipase C-gamma 1 is a substrate of the TrkB receptor. Middlemas, D.S., Meisenhelder, J., Hunter, T. J. Biol. Chem. (1994)
- Expression of mRNA encoding neurotrophins and neurotrophin receptors in rat thymus, spleen tissue and immunocompetent cells. Regulation of neurotrophin-4 mRNA expression by mitogens and leukotriene B4. Laurenzi, M.A., Barbany, G., Timmusk, T., Lindgren, J.A., Persson, H. Eur. J. Biochem. (1994)
- Differential effects of cortical neurotrophic factors on development of lateral geniculate nucleus and superior colliculus neurons: anterograde and retrograde actions. Wahle, P., Di Cristo, G., Schwerdtfeger, G., Engelhardt, M., Berardi, N., Maffei, L. Development (2003)
- Comparison of survival-promoting effects of brain-derived neurotrophic factor and neurotrophin-3 on PC12h cells stably expressing TrkB receptor. Nakatani, A., Yamada, M., Asada, A., Okada, M., Ikeuchi, T., Hatanaka, H. J. Biochem. (1998)
- Ectopic expression of a chimeric colony-stimulating factor-1/TrkB-receptor promotes CSF-1-dependent survival of cultured sympathetic neurons. Erdmann, K.S., Kaiser, A.D., Klinz, F.J., Zhong, J., Krautwald, S., Heumann, R. Biochem. Biophys. Res. Commun. (1998)
- Mixed-lineage kinase inhibitors require the activation of Trk receptors to maintain long-term neuronal trophism and survival. Wang, L.H., Paden, A.J., Johnson, E.M. J. Pharmacol. Exp. Ther. (2005)
- Constitutive phosphorylation of TrkC receptors in cultured cerebellar granule neurons might be responsible for the inability of NT-3 to increase neuronal survival and to activate p21 Ras. Zirrgiebel, U., Lindholm, D. Neurochem. Res. (1996)
- Synaptic and extrasynaptic localization of brain-derived neurotrophic factor and the tyrosine kinase B receptor in cultured hippocampal neurons. Swanwick, C.C., Harrison, M.B., Kapur, J. J. Comp. Neurol. (2004)
- Up-regulation of tyrosine kinase (Trka, Trkb) receptor expression and phosphorylation in lumbosacral dorsal root ganglia after chronic spinal cord (T8-T10) injury. Qiao, L., Vizzard, M.A. J. Comp. Neurol. (2002)
- The effects of brain-derived neurotrophic factor (BDNF) administration on kindling induction, Trk expression and seizure-related morphological changes. Xu, B., Michalski, B., Racine, R.J., Fahnestock, M. Neuroscience (2004)
- Enriched environment during adolescence changes brain-derived neurotrophic factor and TrkB levels in the rat visual system but does not offer neuroprotection to retinal ganglion cells following axotomy. Franklin, T.B., Murphy, J.A., Myers, T.L., Clarke, D.B., Currie, R.W. Brain Res. (2006)