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Gene Review

ADH1C  -  alcohol dehydrogenase 1C (class I), gamma...

Gallus gallus

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Disease relevance of ADH1C

  • In human hepatoma cell lines and differentiated primary and secondary chick fibroblasts, no ADH activity was demonstrable; such cells were not inhibited by 100 mM ethanol additions and DNA synthesis rates were similar to untreated cultures [1].

High impact information on ADH1C


Biological context of ADH1C


Anatomical context of ADH1C


Associations of ADH1C with chemical compounds


Analytical, diagnostic and therapeutic context of ADH1C

  • SDS/PAGE and Western blot analysis of the proteins indicated that the level of a 38-kDa protein that cross-reacted with antibodies prepared against the chicken ADH was increased 5-7-fold by hormone treatment [5].
  • Alcohol dehydrogenase activity increased during the period studied in both ethanol and control groups, however, ethanol significantly inhibited the enzymatic activity [12].


  1. Ethanol-induced inhibition of liver cell function: I. Effect of ethanol on hormone stimulated hepatocyte DNA synthesis and the role of ethanol metabolism. Carter, E.A., Wands, J.R. Alcohol. Clin. Exp. Res. (1988) [Pubmed]
  2. Intron/exon structure of the chicken pyruvate kinase gene. Lonberg, N., Gilbert, W. Cell (1985) [Pubmed]
  3. cDNA sequence and catalytic properties of a chick embryo alcohol dehydrogenase that oxidizes retinol and 3beta,5alpha-hydroxysteroids. Kedishvili, N.Y., Gough, W.H., Chernoff, E.A., Hurley, T.D., Stone, C.L., Bowman, K.D., Popov, K.M., Bosron, W.F., Li, T.K. J. Biol. Chem. (1997) [Pubmed]
  4. N-terminal acetylation in a third protein family of vertebrate alcohol dehydrogenase/retinal reductase found through a 'proteomics' approach in enzyme characterization. Hirschberg, D., Cederlund, E., Crosas, B., Jonsson, A., Tryggvason, S., Farrés, J., Parés, X., Bergman, T., Jörnvall, H. Cell. Mol. Life Sci. (2001) [Pubmed]
  5. Estrogen induction of alcohol dehydrogenase in the uropygial gland of mallard ducks. Hiremath, L.S., Kessler, P.M., Sasaki, G.C., Kolattukudy, P.E. Eur. J. Biochem. (1992) [Pubmed]
  6. Gene activation of alcohol dehydrogenase in Japanese quail and chicken-quail hybrid embryos. LeVine, J.P., Haley, L.E. Biochem. Genet. (1975) [Pubmed]
  7. Structure and properties of avian small heat shock protein with molecular weight 25 kDa. Panasenko, O.O., Seit Nebi, A., Bukach, O.V., Marston, S.B., Gusev, N.B. Biochim. Biophys. Acta (2002) [Pubmed]
  8. Fast atom bombardment mass spectrometry and chemical analysis in determinations of acyl-blocked protein structures. Egestad, B., Estonius, M., Danielsson, O., Persson, B., Cederlund, E., Kaiser, R., Holmquist, B., Vallee, B., Parés, X., Jefferey, J. FEBS Lett. (1990) [Pubmed]
  9. Avian alcohol dehydrogenase: the chicken liver enzyme. Primary structure, cDNA-cloning, and relationships to other alcohol dehydrogenases. Estonius, M., Karlsson, C., Fox, E.A., Höög, J.O., Holmquist, B., Vallee, B.L., Davidson, W.S., Jörnvall, H. Eur. J. Biochem. (1990) [Pubmed]
  10. Vitamin A metabolism in chick liver: some properties of the cytosolic lipid-protein aggregate. Sklan, D., Halevy, O. Br. J. Nutr. (1984) [Pubmed]
  11. Chick embryonic development following exposure to ethanol and pyrazole. Gilani, S.H., Sachdev, R., Persaud, T.V. Anatomischer Anzeiger. (1986) [Pubmed]
  12. Influence of ethanol on liver and plasma lipid levels during chick embryo development. Sanchez-Amate, M.C., Segovia, J.L., Marco, C. Biochem. Int. (1991) [Pubmed]
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