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PDXK  -  pyridoxal (pyridoxine, vitamin B6) kinase

Sus scrofa

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Disease relevance of PDXK


High impact information on PDXK


Biological context of PDXK


Anatomical context of PDXK


Associations of PDXK with chemical compounds


Regulatory relationships of PDXK

  • Since the concentration of free Zn++ in mammalian tissues is lower than 10(-9)M, it is postulated that the concentration of metallothionein regulates the catalytic activity of pyridoxal kinase [10].

Other interactions of PDXK

  • Moreover, binding profiles of both enzymes to immobilized PK were altered by excess amount of PLP [7].
  • The apoprotein of metallothionein as well as the peptide LYS-CYS-THR-CYS-CYS-ALA exert a strong inhibitory effect upon pyridoxal kinase by sequestering free Zn ions [10].

Analytical, diagnostic and therapeutic context of PDXK


  1. Inactivation of microbial pyridoxal kinase by pyridoxal. Furukawa, Y., Yamada, R., Iwashima, A. Acta Vitaminol. Enzymol. (1981) [Pubmed]
  2. Crystal structure of pyridoxal kinase in complex with roscovitine and derivatives. Tang, L., Li, M.H., Cao, P., Wang, F., Chang, W.R., Bach, S., Reinhardt, J., Ferandin, Y., Galons, H., Wan, Y., Gray, N., Meijer, L., Jiang, T., Liang, D.C. J. Biol. Chem. (2005) [Pubmed]
  3. Nucleoside phosphorothioates as probes of the nucleotide binding site of brain pyridoxal kinase. Churchich, J.E., Wu, C. J. Biol. Chem. (1982) [Pubmed]
  4. Brain pyridoxal kinase. Purification, substrate specificities, and sensitized photodestruction of an essential histidine. Kwok, F., Churchich, J.E. J. Biol. Chem. (1979) [Pubmed]
  5. Study of substrate-enzyme interaction between immobilized pyridoxamine and recombinant porcine pyridoxal kinase using surface plasmon resonance biosensor. Fong, C.C., Lai, W.P., Leung, Y.C., Lo, S.C., Wong, M.S., Yang, M. Biochim. Biophys. Acta (2002) [Pubmed]
  6. Pyridoxine transport in brush border membrane vesicles of guinea pig jejunum. Yoshida, S., Hayashi, K., Kawasaki, T. J. Nutr. Sci. Vitaminol. (1981) [Pubmed]
  7. Interaction between pyridoxal kinase and pyridoxal-5-phosphate-dependent enzymes. Cheung, P.Y., Fong, C.C., Ng, K.T., Lam, W.C., Leung, Y.C., Tsang, C.W., Yang, M., Wong, M.S. J. Biochem. (2003) [Pubmed]
  8. Interaction between pyridoxal kinase and pyridoxine-5-P oxidase, two enzymes involved in the metabolism of vitamin B6. Kwok, F., Churchich, J.E. J. Biol. Chem. (1980) [Pubmed]
  9. Brain pyridoxal kinase. Mechanism of substrate addition, binding of ATP, and rotational mobility of the inhibitor pyridoxaloxime. Churchich, J.E., Wu, C. J. Biol. Chem. (1981) [Pubmed]
  10. Modulation of the catalytic activity of pyridoxal kinase by metallothionein. Churchich, J.E., Scholz, G., Kwok, F. Biochem. Int. (1988) [Pubmed]
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