High impact information on LOC398337

• Microinjection of a posteriorly expressed homeobox mRNA can respecify anteroposterior identity, transforming head mesoderm into tail-inducing mesoderm [1].
• In vertebrate embryos, the homeobox gene goosecoid (gsc) is expressed in the gastrula organizer region and in later arising embryonic tissues including the foregut anlage [2].
• In an attempt to identify genes implicated in specification of the regenerate, we screened a newt forelimb blastema cDNA library with homeobox probes, and isolated and sequenced clones that identify a 1.8 kb polyadenylated transcript containing a homeobox [3].
• The function of siamois, a wnt-inducible homeobox gene, in Spemann's organizer development was examined by fusion of defined transcriptional regulatory domains to the siamois homeodomain [4].
• Scores of homeobox gene-encoded transcription factors are expressed in a definite spatiotemporal pattern during embryogenesis and regulate a series of as yet unidentified target genes to help coordinate the morphogenetic process [5].

Biological context of LOC398337

• We describe a novel Xenopus homeobox gene, Xvent-2, which together with the previously identified homeobox gene Xvent-1, defines a novel class of homeobox genes. vent genes are related by sequence homology, expression pattern and gain-of-function phenotype [6].
• Extensive analyses of homeobox gene expression and function during murine embryogenesis have demonstrated that homeobox gene products are key components in the establishment of pattern formation and regional identity during development [7].
• The vertebrate Six3 gene a homeobox gene of the Six-family, plays a crucial role in early eye and forebrain development [8].
• Transcriptional regulation of Xbr-1a/Xvent-2 homeobox gene: analysis of its promoter region [9].
• Four members of the Hox-2 homeobox gene cluster have limits of expression at rhombomere boundaries [10].

Anatomical context of LOC398337

• Regional expression of the homeobox gene NKX2-1 defines pallidal and interneuronal populations in the basal ganglia of amphibians [11].

Other interactions of LOC398337

• XHex is unique amongst homeobox genes in displaying expression in the endothelial layer throughout the developing vasculature [12].
• Homeobox genes like Otx-2 and members of the Hox family have been implicated in this process [13].

References