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Gene Review

hoxb9  -  homeobox B9

Xenopus laevis

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High impact information on LOC398337

  • Microinjection of a posteriorly expressed homeobox mRNA can respecify anteroposterior identity, transforming head mesoderm into tail-inducing mesoderm [1].
  • In vertebrate embryos, the homeobox gene goosecoid (gsc) is expressed in the gastrula organizer region and in later arising embryonic tissues including the foregut anlage [2].
  • In an attempt to identify genes implicated in specification of the regenerate, we screened a newt forelimb blastema cDNA library with homeobox probes, and isolated and sequenced clones that identify a 1.8 kb polyadenylated transcript containing a homeobox [3].
  • The function of siamois, a wnt-inducible homeobox gene, in Spemann's organizer development was examined by fusion of defined transcriptional regulatory domains to the siamois homeodomain [4].
  • Scores of homeobox gene-encoded transcription factors are expressed in a definite spatiotemporal pattern during embryogenesis and regulate a series of as yet unidentified target genes to help coordinate the morphogenetic process [5].

Biological context of LOC398337


Anatomical context of LOC398337

  • Regional expression of the homeobox gene NKX2-1 defines pallidal and interneuronal populations in the basal ganglia of amphibians [11].

Other interactions of LOC398337

  • XHex is unique amongst homeobox genes in displaying expression in the endothelial layer throughout the developing vasculature [12].
  • Homeobox genes like Otx-2 and members of the Hox family have been implicated in this process [13].


  1. Overexpression of a homeodomain protein confers axis-forming activity to uncommitted Xenopus embryonic cells. Cho, K.W., Morita, E.A., Wright, C.V., De Robertis, E.M. Cell (1991) [Pubmed]
  2. Drosophila goosecoid participates in neural development but not in body axis formation. Hahn, M., Jäckle, H. EMBO J. (1996) [Pubmed]
  3. Position dependent expression of a homeobox gene transcript in relation to amphibian limb regeneration. Savard, P., Gates, P.B., Brockes, J.P. EMBO J. (1988) [Pubmed]
  4. Siamois is required for formation of Spemann's organizer. Kessler, D.S. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  5. Binding and transcriptional activation of the promoter for the neural cell adhesion molecule by HoxC6 (Hox-3.3). Jones, F.S., Holst, B.D., Minowa, O., De Robertis, E.M., Edelman, G.M. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  6. The Xvent-2 homeobox gene is part of the BMP-4 signalling pathway controlling [correction of controling] dorsoventral patterning of Xenopus mesoderm. Onichtchouk, D., Gawantka, V., Dosch, R., Delius, H., Hirschfeld, K., Blumenstock, C., Niehrs, C. Development (1996) [Pubmed]
  7. Sequence, genomic organization, and expression of the novel homeobox gene Hesx1. Thomas, P.Q., Johnson, B.V., Rathjen, J., Rathjen, P.D. J. Biol. Chem. (1995) [Pubmed]
  8. A screen for co-factors of Six3. Tessmar, K., Loosli, F., Wittbrodt, J. Mech. Dev. (2002) [Pubmed]
  9. Transcriptional regulation of Xbr-1a/Xvent-2 homeobox gene: analysis of its promoter region. Lee, H.S., Park, M.J., Lee, S.Y., Hwang, Y.S., Lee, H., Roh, D.H., Kim, J.I., Park, J.B., Lee, J.Y., Kung, H.F., Kim, J. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  10. Molecular mechanisms of pattern formation in the vertebrate hindbrain. Nieto, M.A., Bradley, L.C., Hunt, P., Das Gupta, R., Krumlauf, R., Wilkinson, D.G. Ciba Found. Symp. (1992) [Pubmed]
  11. Regional expression of the homeobox gene NKX2-1 defines pallidal and interneuronal populations in the basal ganglia of amphibians. González, A., López, J.M., Sánchez-Camacho, C., Marín, O. Neuroscience (2002) [Pubmed]
  12. The XHex homeobox gene is expressed during development of the vascular endothelium: overexpression leads to an increase in vascular endothelial cell number. Newman, C.S., Chia, F., Krieg, P.A. Mech. Dev. (1997) [Pubmed]
  13. Patterning of the embryo along the anterior-posterior axis: the role of the caudal genes. Epstein, M., Pillemer, G., Yelin, R., Yisraeli, J.K., Fainsod, A. Development (1997) [Pubmed]
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