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Gene Review

phoP  -  DNA-binding transcriptional regulator PhoP

Escherichia coli UTI89

 
 
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Disease relevance of phoP

 

High impact information on phoP

  • The LrpA protein from the hyperthermophilic archaeon Pyrococcus furiosus belongs to the Lrp/AsnC family of transcriptional regulatory proteins, of which the Escherichia coli leucine-responsive regulatory protein is the archetype [4].
  • Sequences homologous to phoP were found in several Gram-negative species and in the yeast Saccharomyces cerevisiae [1].
  • These conditionally essential genes were then evaluated using a genome scale metabolic and transcriptional-regulatory model of E. coli, and it was found that the model made the correct prediction in approximately 91% of the cases [5].
  • Transcriptional regulatory network refinement and quantification through kinetic modeling, gene expression microarray data and information theory [6].
  • Macrophages also processed phoP S. typhimurium strains with greater efficiency for peptide presentation by I-Ak than wild type bacteria while Salmonella constitutively expressing phoP were processed for peptide presentation by I-Ak less efficiently than wild type Salmonella [7].

References

  1. Salmonella typhimurium phoP virulence gene is a transcriptional regulator. Groisman, E.A., Chiao, E., Lipps, C.J., Heffron, F. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  2. The PhoP/PhoQ two-component system stabilizes the alternative sigma factor RpoS in Salmonella enterica. Tu, X., Latifi, T., Bougdour, A., Gottesman, S., Groisman, E.A. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. Cloning and nucleotide sequence of phoP, the regulatory gene for alkaline phosphatase and phosphodiesterase in Bacillus subtilis. Seki, T., Yoshikawa, H., Takahashi, H., Saito, H. J. Bacteriol. (1987) [Pubmed]
  4. Crystal structure of the Lrp-like transcriptional regulator from the archaeon Pyrococcus furiosus. Leonard, P.M., Smits, S.H., Sedelnikova, S.E., Brinkman, A.B., de Vos, W.M., van der Oost, J., Rice, D.W., Rafferty, J.B. EMBO J. (2001) [Pubmed]
  5. Experimental and Computational Assessment of Conditionally Essential Genes in Escherichia coli. Joyce, A.R., Reed, J.L., White, A., Edwards, R., Osterman, A., Baba, T., Mori, H., Lesely, S.A., Palsson, B.?.?., Agarwalla, S. J. Bacteriol. (2006) [Pubmed]
  6. Transcriptional regulatory network refinement and quantification through kinetic modeling, gene expression microarray data and information theory. Sayyed-Ahmad, A., Tuncay, K., Ortoleva, P.J. BMC Bioinformatics (2007) [Pubmed]
  7. Bacterial antigen delivery systems: phagocytic processing of bacterial antigens for MHC-I and MHC-II presentation to T cells. Svensson, M., Pfeifer, J., Stockinger, B., Wick, M.J. Behring Inst. Mitt. (1997) [Pubmed]
 
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