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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

phoP  -  DNA-binding transcriptional regulator PhoP

Escherichia coli O157:H7 str. EDL933

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Disease relevance of phoP

  • We present here the DNA sequence of the phoP gene and show that the deduced amino acid sequence of phoP has extensive homology with the Escherichia coli transcriptional regulators PhoB and OmpR, which control the expression of loci in response to different environmental stimuli [1].
  • Mutation of the phoP gene rendered Salmonella as sensitive to hydrogen peroxide as an rpoS mutant after growth in low Mg(2+) [2].
  • As expected, LcrF exhibited 98% homology to VirF of Yersinia enterocolitica and significant homology to the carboxy termini of other members of the AraC family of transcriptional regulatory proteins [3].

High impact information on phoP


Biological context of phoP


Anatomical context of phoP

  • Macrophages also processed phoP S. typhimurium strains with greater efficiency for peptide presentation by I-Ak than wild type bacteria while Salmonella constitutively expressing phoP were processed for peptide presentation by I-Ak less efficiently than wild type Salmonella [9].


  1. Salmonella typhimurium phoP virulence gene is a transcriptional regulator. Groisman, E.A., Chiao, E., Lipps, C.J., Heffron, F. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  2. The PhoP/PhoQ two-component system stabilizes the alternative sigma factor RpoS in Salmonella enterica. Tu, X., Latifi, T., Bougdour, A., Gottesman, S., Groisman, E.A. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. Temperature sensing in Yersinia pestis: regulation of yopE transcription by lcrF. Hoe, N.P., Minion, F.C., Goguen, J.D. J. Bacteriol. (1992) [Pubmed]
  4. Crystal structure of the Lrp-like transcriptional regulator from the archaeon Pyrococcus furiosus. Leonard, P.M., Smits, S.H., Sedelnikova, S.E., Brinkman, A.B., de Vos, W.M., van der Oost, J., Rice, D.W., Rafferty, J.B. EMBO J. (2001) [Pubmed]
  5. Experimental and Computational Assessment of Conditionally Essential Genes in Escherichia coli. Joyce, A.R., Reed, J.L., White, A., Edwards, R., Osterman, A., Baba, T., Mori, H., Lesely, S.A., Palsson, B.?.?., Agarwalla, S. J. Bacteriol. (2006) [Pubmed]
  6. Nucleotide sequence of the Bacillus subtilis phoR gene. Seki, T., Yoshikawa, H., Takahashi, H., Saito, H. J. Bacteriol. (1988) [Pubmed]
  7. Safety and immunogenicity of phoP/phoQ-deleted Salmonella typhi expressing Helicobacter pylori urease in adult volunteers. DiPetrillo, M.D., Tibbetts, T., Kleanthous, H., Killeen, K.P., Hohmann, E.L. Vaccine (1999) [Pubmed]
  8. Transcriptional regulatory network refinement and quantification through kinetic modeling, gene expression microarray data and information theory. Sayyed-Ahmad, A., Tuncay, K., Ortoleva, P.J. BMC Bioinformatics (2007) [Pubmed]
  9. Bacterial antigen delivery systems: phagocytic processing of bacterial antigens for MHC-I and MHC-II presentation to T cells. Svensson, M., Pfeifer, J., Stockinger, B., Wick, M.J. Behring Inst. Mitt. (1997) [Pubmed]
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