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Gene Review

LIF  -  leukemia inhibitory factor

Sus scrofa

 
 
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Disease relevance of LIF

  • CONCLUSIONS: These results suggest that PBR may be implicated in ischemia-reperfusion injury and, particularly, in the regenerative process within proximal tubules with LIF [1].
  • STUDY DESIGN: PBR, LIF, and LIF receptor messengers and proteins were analyzed in adult normal and ischemic kidney under conditions mimicking cardiac arrest: 18 pigs were studied after 60 minutes of warm ischemia and reperfusion for 7 days and compared with sham-operated (Sham, n = 12) and control (CONT, n = 12) groups [1].
 

High impact information on LIF

 

Biological context of LIF

  • Molecular characterization and chromosome assignment of the porcine gene for leukemia inhibitory factor LIF [5].
  • At the LIF locus, the allele frequencies were 0.27 for the A allele and 0.73 for the B allele [6].
 

Anatomical context of LIF

  • The effects on porcine PGC proliferation of leukemia inhibitory factor (LIF), LIF + stem cell factor (SCF) or LIF + SCF + basic fibroblast growth factor (bFGF), growth factors shown to be essential for in vitro survival and proliferation of murine PGC, were tested [7].
 

Other interactions of LIF

  • Acidic and basic FGF, IL-1 beta, TGF beta and PDGF AB produce similar but smaller effects, while HGF, VEGF, EGF, KGF, and LIF produce small to moderate elevations in stromelysin with minimal other responses [8].
  • Oncostatin M (OSM) is structurally and functionally similar to leukaemia inhibitory factor (LIF), interleukin 6 (IL-6), interleukin 11 (IL-11) and ciliary neurotrophic factor (CNTF) [9].
  • To identify possible pleiotropic marker effects, the growth and carcass traits ADG and backfat thickness were tested for associations with the SNP within the LIF gene in this population [6].

References

  1. Modulation of peripheral-type benzodiazepine receptor during ischemia reperfusion injury in a pig kidney model: a new partner of leukemia inhibitory factor in tubular regeneration. Zhang, K., Desurmont, T., Goujon, J.M., Favreau, F., Cau, J., Deretz, S., Mauco, G., Carretier, M., Papadopoulos, V., Hauet, T. J. Am. Coll. Surg. (2006) [Pubmed]
  2. Leukemia inhibitory factor antagonizes gonadotropin induced-testosterone synthesis in cultured porcine leydig cells: sites of action. Mauduit, C., Goddard, I., Besset, V., Tabone, E., Rey, C., Gasnier, F., Dacheux, F., Benahmed, M. Endocrinology (2001) [Pubmed]
  3. Ontogeny of elongation and gene expression in the early developing porcine conceptus. Yelich, J.V., Pomp, D., Geisert, R.D. Biol. Reprod. (1997) [Pubmed]
  4. Oncostatin M: a new potent inhibitor of iodine metabolism inhibits thyroid peroxidase gene expression but not DNA synthesis in porcine thyroid cells in culture. Isozaki, O., Tsushima, T., Miyakawa, M., Emoto, N., Demura, H., Arai, M., Sato-Nozoe, Y. Thyroid (1997) [Pubmed]
  5. Molecular characterization and chromosome assignment of the porcine gene for leukemia inhibitory factor LIF. Spötter, A., Drögemüller, C., Kuiper, H., Brenig, B., Leeb, T., Distl, O. Cytogenet. Cell Genet. (2001) [Pubmed]
  6. Evidence of a new leukemia inhibitory factor-associated genetic marker for litter size in a synthetic pig line. Spötter, A., Drögemüller, C., Hamann, H., Distl, O. J. Anim. Sci. (2005) [Pubmed]
  7. In vitro survival and proliferation of porcine primordial germ cells. Shim, H., Anderson, G.B. Theriogenology (1998) [Pubmed]
  8. Growth factor and cytokine modulation of trabecular meshwork matrix metalloproteinase and TIMP expression. Alexander, J.P., Samples, J.R., Acott, T.S. Curr. Eye Res. (1998) [Pubmed]
  9. Oncostatin M (OSM) stimulates resorption and inhibits synthesis of proteoglycan in porcine articular cartilage explants. Hui, W., Bell, M., Carroll, G. Cytokine (1996) [Pubmed]
 
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