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Gene Review

MMP3  -  matrix metallopeptidase 3 (stromelysin 1,...

Sus scrofa

Synonyms: MMP-3, MMP10
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Disease relevance of MMP3


High impact information on MMP3

  • CONCLUSIONS: JNK activity is necessary for the induction of MMP-3 and MMP-9 by TNFalpha, IL-1alpha, or IL-1beta in TM cells [1].
  • PURPOSE: The cytokines TNF and IL-1 mediate the MMP-3 increase that occurs in response to trabecular meshwork (TM) treatment by laser trabeculoplasty [1].
  • Phosphorylation of components of the JNK signaling pathway and of the transcription factors c-Jun and ATF-2 support a role for this pathway in the induction of MMP-3 and MMP-9 in the TM in response to these cytokines [1].
  • The Fn-f 45-induced increase in MMP-3 and MMP-13 synthesis occurred via an interleukin 1-independent mechanism, since the receptor antagonist of interleukin-1 was unable to block the increased synthesis [2].
  • Fn-f 45 also stimulated the synthesis of MMP-3 (stromelysin-1) from cultured chondrocytes and cartilage cultures [2].

Biological context of MMP3

  • In contrast, the outer meniscus was found to contain higher gene expression for proteins associated with fibrous tissues including type I collagen, and the proteases MMP2 and MMP3 [3].
  • The resultant 8-hour-conditioned culture medium was then tested for factor activity by evaluating its ability to produce two typical trabecular responses to laser treatment, that is, to induce stromelysin expression or to trigger cell division, when applied to fresh organ cultures or to cell cultures [4].
  • The relative resistance of nonhuman link protein to stromelysin may in part be due to a unique amino acid substitution present near the enzymic cleave site [5].
  • CONCLUSION: Because MMP-3 (stromelysin) mRNA showed the highest upregulation, our findings suggest that trabecular cells preferentially degrade and turn over the proteoglycan components of the extracellular matrix in response to short-term exposure to increased hydrostatic pressure with and without Dex as a homeostatic mechanism [6].

Anatomical context of MMP3


Associations of MMP3 with chemical compounds


Regulatory relationships of MMP3

  • Nuclear run-on transcription analysis demonstrated that the TNF alpha-stimulated increase in stromelysin and collagenase message levels was, at least partially, due to increased transcription [7].

Other interactions of MMP3

  • After 1 month, the specimens were rapidly thawed (37 degrees C) and processed for biomechanical, ultrastructural, morphological and immunohistochemical (MMP-1, MMP-2, MMP-3 and MMP-9) analysis [15].
  • We investigated the mRNA and protein expression of fibronectin and stromelysin-1 (matrix metalloproteinase-3, MMP-3) by trabecular cells treated with growth factors present in primary and secondary aqueous humors [10].
  • Acidic and basic FGF, IL-1 beta, TGF beta and PDGF AB produce similar but smaller effects, while HGF, VEGF, EGF, KGF, and LIF produce small to moderate elevations in stromelysin with minimal other responses [16].
  • The immunoreactivity for matrix metalloproteinase-3 (MMP-3) increased in cholesterol-fed coronary arteries, predominantly in the neointima and adventitia [17].
  • RESULTS: The most significant changes were detected in the levels of MMP-3 mRNA in control cells (2.4-fold increase), of TIMP-1 and -2 mRNA in cells treated with Il-1beta (2.6-fold increase) and of MMP-3 mRNA in cells treated with Dex (3.5-fold increase) exposed to 50 mmHg pressure [6].

Analytical, diagnostic and therapeutic context of MMP3


  1. IL-1 and TNF induction of matrix metalloproteinase-3 by c-Jun N-terminal kinase in trabecular meshwork. Hosseini, M., Rose, A.Y., Song, K., Bohan, C., Alexander, J.P., Kelley, M.J., Acott, T.S. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  2. The 45 kDa collagen-binding fragment of fibronectin induces matrix metalloproteinase-13 synthesis by chondrocytes and aggrecan degradation by aggrecanases. Stanton, H., Ung, L., Fosang, A.J. Biochem. J. (2002) [Pubmed]
  3. Region-specific constitutive gene expression in the adult porcine meniscus. Upton, M.L., Chen, J., Setton, L.A. J. Orthop. Res. (2006) [Pubmed]
  4. Mediation of laser trabeculoplasty-induced matrix metalloproteinase expression by IL-1beta and TNFalpha. Bradley, J.M., Anderssohn, A.M., Colvis, C.M., Parshley, D.E., Zhu, X.H., Ruddat, M.S., Samples, J.R., Acott, T.S. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
  5. Link protein shows species variation in its susceptibility to proteolysis. Liu, J., Cassidy, J.D., Allan, A., Neame, P.J., Mort, J.S., Roughley, P.J. J. Orthop. Res. (1992) [Pubmed]
  6. Effects of interleukin-1beta and dexamethasone on the expression of matrix metalloprotease mRNA by trabecular cells exposed to elevated hydrostatic pressure. Ehrich, D., Tripathi, B., Tripathi, R., Duncker, G. Acta ophthalmologica Scandinavica. (2005) [Pubmed]
  7. Tumor necrosis factor alpha and epidermal growth factor regulation of collagenase and stromelysin in adult porcine articular chondrocytes. Mitchell, P.G., Cheung, H.S. J. Cell. Physiol. (1991) [Pubmed]
  8. Effects of mechanical stretching on trabecular matrix metalloproteinases. Bradley, J.M., Kelley, M.J., Zhu, X., Anderssohn, A.M., Alexander, J.P., Acott, T.S. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
  9. Weaning anorexia may contribute to local inflammation in the piglet small intestine. McCracken, B.A., Spurlock, M.E., Roos, M.A., Zuckermann, F.A., Gaskins, H.R. J. Nutr. (1999) [Pubmed]
  10. Trabecular cell expression of fibronectin and MMP-3 is modulated by aqueous humor growth factors. Tripathi, B.J., Tripathi, R.C., Chen, J., Gotsis, S., Li, J. Exp. Eye Res. (2004) [Pubmed]
  11. Metalloproteinase digestion of cartilage proteoglycan. Pattern of cleavage by stromelysin and susceptibility to collagenase. Hughes, C., Murphy, G., Hardingham, T.E. Biochem. J. (1991) [Pubmed]
  12. Localization of bradykinin B(2) receptor in the follicles of porcine ovary and increased expression of matrix metalloproteinase-3 and -20 in cultured granulosa cells by bradykinin treatment. Kimura, A., Kihara, T., Ohkura, R., Ogiwara, K., Takahashi, T. Biol. Reprod. (2001) [Pubmed]
  13. Bafilomycin A1 inhibits IL-1-stimulated proteoglycan degradation by chondrocytes without affecting stromelysin synthesis. Yocum, S.A., Lopresti-Morrow, L.L., Gabel, C.A., Milici, A.J., Mitchell, P.G. Arch. Biochem. Biophys. (1995) [Pubmed]
  14. Ultrastructural changes of the internal elastic lamina in experimental hypercholesterolemic porcine coronary arteries. Kwon, H.M., Kim, D., Hong, B.K., Byun, K.H., Oh, S.H., Kna, J.S., Kim, H.S., Schwartz, R.S., Lerman, A. J. Korean Med. Sci. (1998) [Pubmed]
  15. Rapid thawing increases the fragility of the cryopreserved arterial wall. Buján, J., Pascual, G., García-Honduvilla, N., Gimeno, M.J., Jurado, F., Carrera-San Martín, A., Bellón, J.M. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery. (2000) [Pubmed]
  16. Growth factor and cytokine modulation of trabecular meshwork matrix metalloproteinase and TIMP expression. Alexander, J.P., Samples, J.R., Acott, T.S. Curr. Eye Res. (1998) [Pubmed]
  17. Ultrastructural changes of the external elastic lamina in experimental hypercholesterolemic porcine coronary arteries. Kwon, H.M., Kang, S., Hong, B.K., Kim, D., Park, H.Y., Shin, M.S., Byun, K.H. Yonsei Med. J. (1999) [Pubmed]
  18. Myocardial matrix metalloproteinase activity and abundance with congestive heart failure. Coker, M.L., Thomas, C.V., Clair, M.J., Hendrick, J.W., Krombach, R.S., Galis, Z.S., Spinale, F.G. Am. J. Physiol. (1998) [Pubmed]
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