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Gene Review

PDON2  -  Periodontitis, localized aggressive

Homo sapiens

Synonyms: LAP, PDLA
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High impact information on PDLA

  • Specifically, we study adsorption of poly(L-lactide) (PLLA) and its enantiomer poly(D-lactide) (PDLA) onto layers of surface-grafted PLLA in acetonitrile and chloroform by infrared spectroscopy (IR) [1].
  • Well-homocrystallized enantiomeric blend and nonblended films were prepared from poly(L-lactide), i.e., poly(L-lactic acid) (PLLA) and poly(D-lactide), i.e., poly(D-lactic acid) (PDLA) by crystallization from the melt [2].
  • In the period of 12-24 months, enantiomeric polymer blending significantly retarded the autocatalytic hydrolysis of the PLLA/PDLA blend film compared with that of the nonblended PLLA and PDLA films [2].
  • PEG modulated release of etanidazole from implantable PLGA/PDLA discs [3].
  • The cytocompatible polymer was composed of 2-methacryloyloxyethyl phosphorylcholine (MPC), n-butyl methacrylate (BMA), and the enantiomeric PLLA (or PDLA) macromonomer [4].

Biological context of PDLA

  • The porous scaffold was prepared by the formation of a stereocomplex between the PLLA and PDLA, and the cell adhesion and following cell intrusion was then evaluated [4].

Anatomical context of PDLA

  • The roughness of the membranes ranged from 4 nm for PDLA to 120 nm and they presented very smooth surface except for PCL which beside a macroscopic structure due to its hydrophobicity [5].

Associations of PDLA with chemical compounds

  • Man-made polymers such as polyglycolide (PGA), polylactides (PLLA, PDLA), poly(caprolactone) (PCL), and poly(dioxanone) (PDS) have been studied as matrix material to guide the differentiation and proliferation of cells into the targeted functional premature and/or mature tissue [6].
  • A porous scaffold as a cell-compatible material was designed and prepared using a phospholipid copolymer composed of 2-methacryloyloxyethyl phosphorylcholine (MPC), n-butyl methacrylate, and enantiomeric macromonomers, the poly(L-lactic acid) (PLLA) macromonomer, and poly(D-lactic acid) (PDLA) macromonomer [7].
  • The degree of polymerization of the lactic acid in the PLLA and PDLA segments was designed to be ca. 20. The copolymer-coated surface was analyzed with static contact angle by water [4].
  • OBJECTIVE: To compare the effects of solid barriers (PDLA membrane and foil, Interceed), innovative barrier solutions (Adept and Hyalobarrier Gel, phospholipid emulsion), and Ringer's lactate solution in preventing postsurgical peritoneal adhesions in the rat [8].
  • Hydrogel formation between enantiomeric B-A-B-type block copolymers of polylactides (PLLA or PDLA: A) and polyoxyethylene (PEG: B); PEG-PLLA-PEG and PEG-PDLA-PEG [9].

Analytical, diagnostic and therapeutic context of PDLA


  1. Adsorption of enantiomeric poly(lactide)s on surface-grafted poly(L-lactide). Tretinnikov, O.N., Kato, K., Iwata, H. Langmuir : the ACS journal of surfaces and colloids. (2004) [Pubmed]
  2. In vitro hydrolysis of blends from enantiomeric poly(lactide)s. Part 4: well-homo-crystallized blend and nonblended films. Tsuji, H. Biomaterials (2003) [Pubmed]
  3. PEG modulated release of etanidazole from implantable PLGA/PDLA discs. Wang, F., Lee, T., Wang, C.H. Biomaterials (2002) [Pubmed]
  4. Cell adhesion and morphology in porous scaffold based on enantiomeric poly(lactic acid) graft-type phospholipid polymers. Watanabe, J., Eriguchi, T., Ishihara, K. Biomacromolecules (2002) [Pubmed]
  5. In vitro biocompatibility of different polyester membranes. Vaquette, C., Fawzi-Grancher, S., Lavalle, P., Frochot, C., Viriot, M.L., Muller, S., Wang, X. Bio-medical materials and engineering. (2006) [Pubmed]
  6. An introduction to biodegradable materials for tissue engineering applications. Hutmacher, D.W., Goh, J.C., Teoh, S.H. Ann. Acad. Med. Singap. (2001) [Pubmed]
  7. Stereocomplex formation by enantiomeric poly(lactic acid) graft-type phospholipid polymers for tissue engineering. Watanabe, J., Eriguchi, T., Ishihara, K. Biomacromolecules (2002) [Pubmed]
  8. Innovative barriers for peritoneal adhesion prevention: liquid or solid? A rat uterine horn model. Wallwiener, M., Brucker, S., Hierlemann, H., Brochhausen, C., Solomayer, E., Wallwiener, C. Fertil. Steril. (2006) [Pubmed]
  9. Hydrogel formation between enantiomeric B-A-B-type block copolymers of polylactides (PLLA or PDLA: A) and polyoxyethylene (PEG: B); PEG-PLLA-PEG and PEG-PDLA-PEG. Mukose, T., Fujiwara, T., Nakano, J., Taniguchi, I., Miyamoto, M., Kimura, Y., Teraoka, I., Woo Lee, C. Macromolecular bioscience. (2004) [Pubmed]
  10. Effect of molecular weight and glass transition on relaxation and release behaviour of poly(DL-lactic acid) tablets. Steendam, R., van Steenbergen, M.J., Hennink, W.E., Frijlink, H.W., Lerk, C.F. Journal of controlled release : official journal of the Controlled Release Society. (2001) [Pubmed]
  11. Etanidazole-loaded microspheres fabricated by spray-drying different poly(lactide/glycolide) polymers: effects on microsphere properties. Wang, F.J., Wang, C.H. Journal of biomaterials science. Polymer edition. (2003) [Pubmed]
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