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Gene Review

TACR1  -  tachykinin receptor 1

Bos taurus

 
 
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Disease relevance of nk1R

  • 6. These results are consistent with the contention that NK1 receptors mediate neurogenic plasma protein leakage following trigeminal stimulation, and suggest that NK1 receptor antagonists of the perhydroisoindolone series may be useful for treating migraine and cluster headaches [1].
 

High impact information on nk1R

 

Anatomical context of nk1R

 

Associations of nk1R with chemical compounds

References

  1. Blockade by oral or parenteral RPR 100893 (a non-peptide NK1 receptor antagonist) of neurogenic plasma protein extravasation within guinea-pig dura mater and conjunctiva. Lee, W.S., Moussaoui, S.M., Moskowitz, M.A. Br. J. Pharmacol. (1994) [Pubmed]
  2. Pharmacological properties of peptides derived from an antibody against the tachykinin NK1 receptor for the neuropeptide substance P. Wijkhuisen, A., Tymciu, S., Fischer, J., Alexandrenne, C., Créminon, C., Frobert, Y., Grassi, J., Boquet, D., Conrath, M., Couraud, J.Y. Eur. J. Pharmacol. (2003) [Pubmed]
  3. The expression of substance P and its neurokinin-1 receptor mRNA in the bovine corpus luteum of early developmental stage. Reibiger, I., Aust, G., Tscheudschilsuren, G., Beyer, R., Gebhardt, C., Spanel-Borowski, K. Neurosci. Lett. (2001) [Pubmed]
  4. The tachykinin NK1 receptor antagonist, RP67580, inhibits the bradykinin-induced rise in intracellular Ca2+ concentration in bovine pulmonary artery endothelial cells. Westra-De Vlieger, J.F., Van Den Wijngaard, P.W., Koster, A.S., Wilting, J., Leysen, J., Van Heuven-Nolsen, D., Nijkamp, F.P. Eur. J. Pharmacol. (1998) [Pubmed]
  5. Evidence for non-adrenergic non-cholinergic contractile responses in bovine and swine trachea. Matera, M.G., Amorena, M., Marabese, I., Loffreda, A., D'Agostino, B., Lucisano, A., Rossi, F. Pulmonary pharmacology & therapeutics. (1997) [Pubmed]
  6. Histamine-induced cortisol secretion from bovine adrenocortical cells: co-incubated with bovine adrenal medullary cells. Yoshida, T., Mashimo, S., Mio, M., Kamei, C. Jpn. J. Pharmacol. (1997) [Pubmed]
 
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