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MeSH Review

Dura Mater

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Disease relevance of Dura Mater

  • However, 34 recipients of other tissues--2 receiving corneas, 3 receiving lyophilized soft tissue, 25 receiving ethanol-treated bone, 3 receiving dura mater treated with gamma radiation, and 1 receiving marrow-evacuated, fresh-frozen bone--tested negative for HIV-1 antibody [1].
  • These neoplasms consist of aggressive fibrosarcomas of soft tissue as well as diffuse meningeal tumors originating from the dura mater that surround the whole central nervous system and cause severe hydrocephalus [2].
  • The NO donor glyceryl trinitrate (GTN) provokes delayed migraine attacks when infused into migraineurs and also causes iNOS expression and delayed inflammation within rodent dura mater [3].
  • The analysis of ganglioside distribution in each meningioma showed that in the majority of the cases the increase of ganglioside content was primarily the result of selective accumulation of ganglioside GM3; in the remaining cases ganglioside GM1 was present in a significantly higher amount than in the control dura mater and leptomeninges [4].
  • Interestingly, doses of CP-122,288 that inhibit neurogenic inflammation in rat dura mater (0.3-300 ng kg-1) were demonstrated to be devoid of vasoconstrictor activity in either the carotid or coronary vascular beds of dog [5].

High impact information on Dura Mater

  • April 2004: A 53-year-old woman presented with a large club-shaped intra- and extraspinal tumor of the C6 nerve root which had intradurally grown through the enlarged C5-6 neural foramen and focally infiltrated the dura mater [6].
  • At necropsy, eight whitish nodes and diffuse thickening of the dura mater from C1 to C6 were found [7].
  • The expression of Msx2 in the dura mater disappeared after birth. <P> FGF and BMP signalling pathways were further examined in vitro, in E15 mouse calvarial explants [8].
  • Signals from the dura mater may regulate the maintenance of sutural patency prenatally, whereas signals in the osteogenic fronts dominate after birth [8].
  • Msx1 and Msx2 were expressed in the sutural mesenchyme and the dura mater [8].

Chemical compound and disease context of Dura Mater


Biological context of Dura Mater


Anatomical context of Dura Mater

  • A cervical MRI revealed an ill-defined, enhancing lesion from C1 to C6, internally attached to the dura mater and compressing the spinal cord [7].
  • Fgf9 was expressed throughout the calvarial mesenchyme, the dura mater, the developing bones and the overlying skin, but Fgf4 was not detected in these tissues [8].
  • Normal Lewis rats (susceptible to both EAN and EAE) had significantly greater numbers of mast cells in the dura mater (about 6x) of the meninges and the sciatic nerve (3x) than Brown Norway rats (resistant to EAE and EAN induction under normal circumstances) [19].
  • Further, the high levels of histamine found in CF-1 mice whose brains had been frozen in situ were accompanied by an extensive degranulation of mast cells in the dura mater of these mice [20].
  • For this purpose, bosentan, a specific non-peptide mixed antagonist of ET receptors, was tested in rat models of neurogenic and non-neurogenic plasma extravasation in the dura mater and extracranial tissues (eyelid, conjunctiva, lip, tongue) [21].

Associations of Dura Mater with chemical compounds

  • Trigeminal afferents of the supratentorial dura mater were activated by mustard oil (MO) and the responses of second-order neurons to stimulation of the greater occipital nerve (GON) were studied before and after dural stimulation [22].
  • Coronal sutures induced to undergo osseous obliteration in vitro after removal of the dura mater were found to require soluble, heparin-binding factors present in dura mater to resist osseous obliteration [23].
  • Glucose and mannitol diffusion in human dura mater [24].
  • Diffusion coefficients of glucose and mannitol in the human dura mater tissue at 20 degrees C have been estimated as (1.63 +/- 0.29) x 10(-6)cm(2)/s and as (1.31 +/- 0.41) x 10(-6) cm(2)/s, respectively [24].
  • Bosentan, a specific mixed antagonist of endothelin receptors with no vasoconstrictor activity, inhibits neurogenic plasma extravasation (NPE) within rat dura mater [25].

Gene context of Dura Mater


Analytical, diagnostic and therapeutic context of Dura Mater


  1. Transmission of human immunodeficiency virus type 1 from a seronegative organ and tissue donor. Simonds, R.J., Holmberg, S.D., Hurwitz, R.L., Coleman, T.R., Bottenfield, S., Conley, L.J., Kohlenberg, S.H., Castro, K.G., Dahan, B.A., Schable, C.A. N. Engl. J. Med. (1992) [Pubmed]
  2. A retrovirus carrying the K-fgf oncogene induces diffuse meningeal tumors and soft-tissue fibrosarcomas. Talarico, D., Ittmann, M.M., Bronson, R., Basilico, C. Mol. Cell. Biol. (1993) [Pubmed]
  3. Nuclear factor-kappaB as a molecular target for migraine therapy. Reuter, U., Chiarugi, A., Bolay, H., Moskowitz, M.A. Ann. Neurol. (2002) [Pubmed]
  4. Modifications of ganglioside patterns in human meningiomas. Berra, B., Riboni, L., De Gasperi, R., Gaini, S.M., Ragnotti, G. J. Neurochem. (1983) [Pubmed]
  5. The in vivo pharmacological profile of a 5-HT1 receptor agonist, CP-122,288, a selective inhibitor of neurogenic inflammation. Gupta, P., Brown, D., Butler, P., Ellis, P., Grayson, K.L., Land, G.C., Macor, J.E., Robson, S.F., Wythes, M.J., Shepperson, N.B. Br. J. Pharmacol. (1995) [Pubmed]
  6. April 2004: woman in her early fifties with a cervical intraspinal and extraspinal mass lesion. Kuchelmeister, K., Lotz, C., Schönmayr, R., Schachenmayr, W. Brain Pathol. (2004) [Pubmed]
  7. October 2000: a 47 year old man with long-standing progressive tetraparesis. Pittella, J.E., da Costa, C.C., Giannetti, A.V., Perpétuo, F.O. Brain Pathol. (2001) [Pubmed]
  8. FGF-, BMP- and Shh-mediated signalling pathways in the regulation of cranial suture morphogenesis and calvarial bone development. Kim, H.J., Rice, D.P., Kettunen, P.J., Thesleff, I. Development (1998) [Pubmed]
  9. Chronic hypertrophic cranial pachymeningitis associated with HTLV-I infection. Kawano, Y., Kira, J. J. Neurol. Neurosurg. Psychiatr. (1995) [Pubmed]
  10. Long-term superior cervical sympathectomy induces mast cell hyperplasia and increases histamine and serotonin content in the rat dura mater. Bergerot, A., Reynier-Rebuffel, A.M., Callebert, J., Aubineau, P. Neuroscience (2000) [Pubmed]
  11. Functional relationships between sensory nerve fibers and mast cells of dura mater in normal and inflammatory conditions. Dimitriadou, V., Rouleau, A., Trung Tuong, M.D., Newlands, G.J., Miller, H.R., Luffau, G., Schwartz, J.C., Garbarg, M. Neuroscience (1997) [Pubmed]
  12. Absorbable or nonabsorbable suture materials for closure of the dura mater? Vällfors, B., Hansson, H.A., Svensson, J. Neurosurgery (1981) [Pubmed]
  13. Glyceryl trinitrate treatment up-regulates soluble guanylyl cyclase in rat dura mater. Behrends, S., Knyihár-Csillik, E., Kempfert, J., Scholz, H., Csillik, B., Vécsei, L. Neuroreport (2001) [Pubmed]
  14. Iatrogenic Creutzfeldt-Jakob disease: an example of the interplay between ancient genes and modern medicine. Brown, P., Cervenáková, L., Goldfarb, L.G., McCombie, W.R., Rubenstein, R., Will, R.G., Pocchiari, M., Martinez-Lage, J.F., Scalici, C., Masullo, C. Neurology (1994) [Pubmed]
  15. Capsaicin-sensitive neurogenic sensory vasodilatation in the dura mater of the rat. Dux, M., Sántha, P., Jancsó, G. J. Physiol. (Lond.) (2003) [Pubmed]
  16. Enkephalin-degrading enzymes and angiotensin-converting enzyme in human and rat meninges. Zajac, J.M., Charnay, Y., Soleilhic, J.M., Sales, N., Roques, B.P. FEBS Lett. (1987) [Pubmed]
  17. Proinflammatory cytokines, adhesion molecules, and lymphocyte integrin expression in the internal jugular blood of migraine patients without aura assessed ictally. Sarchielli, P., Alberti, A., Baldi, A., Coppola, F., Rossi, C., Pierguidi, L., Floridi, A., Calabresi, P. Headache. (2006) [Pubmed]
  18. Co-culture of osteoblasts with immature dural cells causes an increased rate and degree of osteoblast differentiation. Spector, J.A., Greenwald, J.A., Warren, S.M., Bouletreau, P.J., Crisera, F.E., Mehrara, B.J., Longaker, M.T. Plast. Reconstr. Surg. (2002) [Pubmed]
  19. An analysis of mast cell frequency in the rodent nervous system: numbers vary between different strains and can be reconstituted in mast cell-deficient mice. Johnson, D., Yasui, D., Seeldrayers, P. J. Neuropathol. Exp. Neurol. (1991) [Pubmed]
  20. Dural mast cells: source of contaminating histamine in analyses of mouse brain histamine levels. Orr, E.L. J. Neurochem. (1984) [Pubmed]
  21. Role of endothelin in mediating neurogenic plasma extravasation in rat dura mater. Brändli, P., Löffler, B.M., Breu, V., Osterwalder, R., Maire, J.P., Clozel, M. Pain (1996) [Pubmed]
  22. Increased responses in trigeminocervical nociceptive neurons to cervical input after stimulation of the dura mater. Bartsch, T., Goadsby, P.J. Brain (2003) [Pubmed]
  23. TGF-beta 1, TGF-beta 2, and TGF-beta 3 exhibit distinct patterns of expression during cranial suture formation and obliteration in vivo and in vitro. Opperman, L.A., Nolen, A.A., Ogle, R.C. J. Bone Miner. Res. (1997) [Pubmed]
  24. Glucose and mannitol diffusion in human dura mater. Bashkatov, A.N., Genina, E.A., Sinichkin, Y.P., Kochubey, V.I., Lakodina, N.A., Tuchin, V.V. Biophys. J. (2003) [Pubmed]
  25. Endothelin antagonist bosentan blocks neurogenic inflammation, but is not effective in aborting migraine attacks. May, A., Gijsman, H.J., Wallnöfer, A., Jones, R., Diener, H.C., Ferrari, M.D. Pain (1996) [Pubmed]
  26. Expression of mRNAs for neurotrophins and their receptors in the rat choroid plexus and dura mater. Timmusk, T., Mudò, G., Metsis, M., Belluardo, N. Neuroreport (1995) [Pubmed]
  27. Stress-induced dura vascular permeability does not develop in mast cell-deficient and neurokinin-1 receptor knockout mice. Kandere-Grzybowska, K., Gheorghe, D., Priller, J., Esposito, P., Huang, M., Gerard, N., Theoharides, T.C. Brain Res. (2003) [Pubmed]
  28. Release of histamine from dural mast cells by substance P and calcitonin gene-related peptide. Ottosson, A., Edvinsson, L. Cephalalgia : an international journal of headache. (1997) [Pubmed]
  29. Effects of eletriptan on the peptidergic innervation of the cerebral dura mater and trigeminal ganglion, and on the expression of c-fos and c-jun in the trigeminal complex of the rat in an experimental migraine model. Knyihár-Csillik, E., Tajti, J., Csillik, A.E., Chadaide, Z., Mihály, A., Vécsei, L. Eur. J. Neurosci. (2000) [Pubmed]
  30. Increase in meningeal blood flow by nitric oxide--interaction with calcitonin gene-related peptide receptor and prostaglandin synthesis inhibition. Strecker, T., Dux, M., Messlinger, K. Cephalalgia : an international journal of headache. (2002) [Pubmed]
  31. Ethylene oxide sterilization of bone, dura mater, and fascia lata for human transplantation. Prolo, D.J., Pedrotti, P.W., White, D.H. Neurosurgery (1980) [Pubmed]
  32. Laser tissue welding of dura mater and peripheral nerves: a scanning electron microscopy study. Menovsky, T., Beek, J.F., van Gemert, M.J. Lasers in surgery and medicine. (1996) [Pubmed]
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