The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

PTGS2  -  prostaglandin-endoperoxide synthase 2...

Bos taurus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of PTGS2


High impact information on PTGS2


Biological context of PTGS2


Anatomical context of PTGS2


Associations of PTGS2 with chemical compounds


Physical interactions of PTGS2


Regulatory relationships of PTGS2


Other interactions of PTGS2

  • The expression of cyclooxygenase (COX)-1 and COX-2 mRNAs and proteins and PGE synthase (PGES) mRNA was analyzed by Northern and Western blot [6].
  • In experiment 1, staining for COX-2 was maximal between d18P and d24P, both in the LE and in the conceptus, whereas staining for GM-CSF reached a plateau between d18P and d30P in the LE [10].
  • In experiment 2, in response to IFN-tau, COX-2 was up-regulated in the LE of the ipsilateral horn, whereas GM-CSF was enhanced in both uterine horns [10].
  • Consistent with the increased expression of COX-2, BBMEC monolayers exposed to TNF-alpha had significantly greater secretion and release of prostaglandin E(2) (PGE(2)) and prostaglandin F(2alpha) (PGF(2alpha)) [9].
  • Accumulation of cyclooxygenase-2 gene transcripts in uterine tissues of pregnant and parturient cows: stimulation by oxytocin [8].

Analytical, diagnostic and therapeutic context of PTGS2


  1. Interaction between NO and COX pathways in retinal cells exposed to elevated glucose and retina of diabetic rats. Du, Y., Sarthy, V.P., Kern, T.S. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2004) [Pubmed]
  2. Expression and function of Toll-like receptor 4 in the endometrial cells of the uterus. Herath, S., Fischer, D.P., Werling, D., Williams, E.J., Lilly, S.T., Dobson, H., Bryant, C.E., Sheldon, I.M. Endocrinology (2006) [Pubmed]
  3. Cell density influences the effect of celecoxib in two carcinoma cell lines. Vital-Reyes, V.S., Rodríguez-Burford, C., Oelschlager, D.K., Grizzle, W.E. Biotechnic & histochemistry : official publication of the Biological Stain Commission. (2006) [Pubmed]
  4. Role of upstream stimulatory factor phosphorylation in the regulation of the prostaglandin G/H synthase-2 promoter in granulosa cells. Sayasith, K., Lussier, J.G., Sirois, J. J. Biol. Chem. (2005) [Pubmed]
  5. Molecular characterization and role of bovine upstream stimulatory factor 1 and 2 in the regulation of the prostaglandin G/H synthase-2 promoter in granulosa cells. Sayasith, K., Bouchard, N., Sawadogo, M., Lussier, J.G., Sirois, J. J. Biol. Chem. (2004) [Pubmed]
  6. Expression of cyclooxygenases 1 and 2 and prostaglandin E synthase in bovine endometrial tissue during the estrous cycle. Arosh, J.A., Parent, J., Chapdelaine, P., Sirois, J., Fortier, M.A. Biol. Reprod. (2002) [Pubmed]
  7. Transcriptional regulation of the cyclooxygenase-2 gene changes from protein kinase (PK) A- to PKC-dependence after luteinization of granulosa cells. Wu, Y.L., Wiltbank, M.C. Biol. Reprod. (2002) [Pubmed]
  8. Accumulation of cyclooxygenase-2 gene transcripts in uterine tissues of pregnant and parturient cows: stimulation by oxytocin. Fuchs, A.R., Rust, W., Fields, M.J. Biol. Reprod. (1999) [Pubmed]
  9. Tumor necrosis factor-alpha induces cyclooxygenase-2 expression and prostaglandin release in brain microvessel endothelial cells. Mark, K.S., Trickler, W.J., Miller, D.W. J. Pharmacol. Exp. Ther. (2001) [Pubmed]
  10. Expression of cyclooxygenase-2 and granulocyte-macrophage colony-stimulating factor in the endometrial epithelium of the cow is up-regulated during early pregnancy and in response to intrauterine infusions of interferon-tau. Emond, V., MacLaren, L.A., Kimmins, S., Arosh, J.A., Fortier, M.A., Lambert, R.D. Biol. Reprod. (2004) [Pubmed]
  11. Differential expression of cyclooxygenase 1 and cyclooxygenase 2 in the bovine oviduct. Odau, S., Gabler, C., Holder, C., Einspanier, R. J. Endocrinol. (2006) [Pubmed]
  12. Expression of microsomal prostaglandin E synthase in bovine endometrium: coexpression with cyclooxygenase type 2 and regulation by interferon-tau. Parent, J., Chapdelaine, P., Sirois, J., Fortier, M.A. Endocrinology (2002) [Pubmed]
  13. Regulation of cyclooxygenase-2 expression in bovine chondrocytes in culture by interleukin 1alpha, tumor necrosis factor-alpha, glucocorticoids, and 17beta-estradiol. Morisset, S., Patry, C., Lora, M., de Brum-Fernandes, A.J. J. Rheumatol. (1998) [Pubmed]
  14. Differential regulation of cyclooxygenase isoenzymes by cAMP-elevating agents. Samokovlisky, A., Rimon, G., Danon, A. Eur. J. Pharmacol. (1999) [Pubmed]
  15. Induction of PG G/H synthase-2 in bovine myometrial cells by interferon-tau requires the activation of the p38 MAPK pathway. Doualla-Bell, F., Koromilas, A.E. Endocrinology (2001) [Pubmed]
  16. In-vitro test system for the evaluation of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) inhibitors based on a single HPLC run with UV detection using bovine aortic coronary endothelial cells (BAECs). Dannhardt, G., Ulbrich, H. Inflamm. Res. (2001) [Pubmed]
  17. Reactive oxygen species up-regulates cyclooxygenase-2, p53, and Bax mRNA expression in bovine luteal cells. Nakamura, T., Sakamoto, K. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  18. Down-regulation of oxytocin-induced cyclooxygenase-2 and prostaglandin F synthase expression by interferon-tau in bovine endometrial cells. Xiao, C.W., Murphy, B.D., Sirois, J., Goff, A.K. Biol. Reprod. (1999) [Pubmed]
WikiGenes - Universities