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Usf2  -  upstream transcription factor 2

Mus musculus

Synonyms: Major late transcription factor 2, Upstream stimulatory factor 2, Upstream transcription factor 2, Usf-2, bHLHb12
 
 
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Disease relevance of Usf2

 

High impact information on Usf2

 

Biological context of Usf2

  • To identify genes that may account for the abnormalities of iron homeostasis in Usf2(-/-) mice, we used suppressive subtractive hybridization between livers from Usf2(-/-) and wild-type mice [1].
  • However, lactation performance in Usf2-/- females was only half of that observed in Usf2+/+ females, and both lactose and nitrogen were decreased in milk from Usf2-/- dams [4].
  • Blood oxytocin concentrations on d 9 postpartum were also lower in Usf2-/- mice than Usf2+/+ mice [4].
 

Anatomical context of Usf2

  • Mutation of the Usf2 gene was associated with reduced fertility in females, but had no effect on prepartum mammary gland development [4].
 

Associations of Usf2 with chemical compounds

 

Regulatory relationships of Usf2

 

Other interactions of Usf2

References

  1. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Nicolas, G., Bennoun, M., Devaux, I., Beaumont, C., Grandchamp, B., Kahn, A., Vaulont, S. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  2. Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Nicolas, G., Bennoun, M., Porteu, A., Mativet, S., Beaumont, C., Grandchamp, B., Sirito, M., Sawadogo, M., Kahn, A., Vaulont, S. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  3. Overlapping roles and asymmetrical cross-regulation of the USF proteins in mice. Sirito, M., Lin, Q., Deng, J.M., Behringer, R.R., Sawadogo, M. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  4. Diminished milk synthesis in upstream stimulatory factor 2 null mice is associated with decreased circulating oxytocin and decreased mammary gland expression of eukaryotic initiation factors 4E and 4G. Hadsell, D.L., Bonnette, S., George, J., Torres, D., Klementidis, Y., Gao, S., Haney, P.M., Summy-Long, J., Soloff, M.S., Parlow, A.F., Sirito, M., Sawadogo, M. Mol. Endocrinol. (2003) [Pubmed]
  5. Glucose-dependent liver gene expression in upstream stimulatory factor 2 -/- mice. Vallet, V.S., Henrion, A.A., Bucchini, D., Casado, M., Raymondjean, M., Kahn, A., Vaulont, S. J. Biol. Chem. (1997) [Pubmed]
  6. Upstream stimulatory factor 2 stimulates transcription through an initiator element in the mouse cytochrome c oxidase subunit Vb promoter. Breen, G.A., Jordan, E.M. Biochim. Biophys. Acta (2000) [Pubmed]
  7. Murine chromosomal location of five bHLH-Zip transcription factor genes. Steingrímsson, E., Sawadogo, M., Gilbert, D.J., Zervos, A.S., Brent, R., Blanar, M.A., Fisher, D.E., Copeland, N.G., Jenkins, N.A. Genomics (1995) [Pubmed]
 
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