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Gene Review

CDH6  -  cadherin 6, type 2, K-cadherin (fetal kidney)

Gallus gallus

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Disease relevance of CDH6

  • In addition, cadherin-6B and cadherin-7 are expressed by a subset of ganglion cells that project to several retinorecipient nuclei forming part of the accessory optic system (e.g., nucleus of the basal optic root and external pretectal nucleus) [1].

High impact information on CDH6

  • In the chicken embryo, the early neural tube expresses two cadherins, N-cadherin and cadherin-6B (cad6B), in the dorsal-most region where neural crest cells are generated [2].
  • We identified two cadherins, c-cad6B and c-cad7, expressed by neural crest cells at their premigratory and migratory stages, respectively, in chicken embryos. cDNA transfection experiments showed that both were homophilic adhesion molecules, endowing cells with specific adhesiveness [3].
  • We studied the expression of four classic cadherins (R-cadherin, N-cadherin, cadherin-6B and cadherin-7) at the synaptic level on the somata and the proximal neurites of identified neuron populations that were traced selectively in the developing chicken visual system [4].
  • RESULTS: In cultures of chicken retinal cells, cadherin-6B (cad6B) and cadherin-7 (cad7) are expressed by distinct neurones, each being distributed in a punctate pattern along their neurites as well as in the soma [5].
  • With this approach, we found that a 10 kb mRNA encoding a homotypic cell adhesion molecule, cadherin 6B, was strongly expressed in differentiated vascular and visceral SMCs, but not in the dedifferentiated SMCs derived from them [6].

Biological context of CDH6


Anatomical context of CDH6


Other interactions of CDH6

  • For example, different (but partly overlapping) populations of bipolar cells express R-cadherin, cadherin-6B, and cadherin-7 [1].

Analytical, diagnostic and therapeutic context of CDH6

  • The expression of three cadherins (cadherin-6B, cadherin-7, and R-cadherin) was analyzed by immunohistochemistry at early to intermediate stages of chicken cerebellar development (4.5-12 days of incubation [E4.5-E12]) [9].
  • By in vivo electroporation in chicken embryos, we demonstrate that Purkinje cell progenitors, which overexpress cadherin-6B or cadherin-7, distribute preferentially to those Purkinje cell domains, which express the respective cadherin endogenously [10].


  1. Cadherin expression in the retina and retinofugal pathways of the chicken embryo. Wöhrn, J.C., Puelles, L., Nakagawa, S., Takeichi, M., Redies, C. J. Comp. Neurol. (1998) [Pubmed]
  2. Neural crest emigration from the neural tube depends on regulated cadherin expression. Nakagawa, S., Takeichi, M. Development (1998) [Pubmed]
  3. Neural crest cell-cell adhesion controlled by sequential and subpopulation-specific expression of novel cadherins. Nakagawa, S., Takeichi, M. Development (1995) [Pubmed]
  4. Selective synaptic cadherin expression by traced neurons of the chicken visual system. Heyers, D., Luksch, H., Redies, C. Neuroscience (2004) [Pubmed]
  5. Blockade of cadherin-6B activity perturbs the distribution of PSD-95 family proteins in retinal neurones. Honjo, Y., Nakagawa, S., Takeichi, M. Genes Cells (2000) [Pubmed]
  6. Phenotype-dependent expression of cadherin 6B in vascular and visceral smooth muscle cells. Chimori, Y., Hayashi, K., Kimura, K., Nishida, W., Funahashi, S., Miyata, S., Shimane, M., Matsuzawa, Y., Sobue, K. FEBS Lett. (2000) [Pubmed]
  7. Cadherin expression by embryonic divisions and derived gray matter structures in the telencephalon of the chicken. Redies, C., Medina, L., Puelles, L. J. Comp. Neurol. (2001) [Pubmed]
  8. Morphologic fate of diencephalic prosomeres and their subdivisions revealed by mapping cadherin expression. Redies, C., Ast, M., Nakagawa, S., Takeichi, M., Martínez-de-la-Torre, M., Puelles, L. J. Comp. Neurol. (2000) [Pubmed]
  9. Development of cadherin-defined parasagittal subdivisions in the embryonic chicken cerebellum. Arndt, K., Redies, C. J. Comp. Neurol. (1998) [Pubmed]
  10. Cadherins guide migrating Purkinje cells to specific parasagittal domains during cerebellar development. Luo, J., Treubert-Zimmermann, U., Redies, C. Mol. Cell. Neurosci. (2004) [Pubmed]
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