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Gene Review

Dop1R1  -  Dopamine 1-like receptor 1

Drosophila melanogaster

Synonyms: CG9652, D-DOP1, D-Dop1, DA1, DmDOP1, ...
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Disease relevance of DopR

  • In addition, the larval abdominal ganglion contained two dDA1 cells in each segment [1].

High impact information on DopR


Biological context of DopR


Anatomical context of DopR


Associations of DopR with chemical compounds

  • However, like vertebrate dopamine D1-like receptors, dDA1 stimulated the accumulation of cAMP in response to DA (EC50 approximately 300 nM) and 6,7-ADTN (EC50 approximately 500 nM) [5].

Analytical, diagnostic and therapeutic context of DopR


  1. Expression of a D1 dopamine receptor dDA1/DmDOP1 in the central nervous system of Drosophila melanogaster. Kim, Y.C., Lee, H.G., Seong, C.S., Han, K.A. Gene Expr. Patterns (2003) [Pubmed]
  2. DAMB, a novel dopamine receptor expressed specifically in Drosophila mushroom bodies. Han, K.A., Millar, N.S., Grotewiel, M.S., Davis, R.L. Neuron (1996) [Pubmed]
  3. Agonist-specific coupling of a cloned Drosophila melanogaster D1-like dopamine receptor to multiple second messenger pathways by synthetic agonists. Reale, V., Hannan, F., Hall, L.M., Evans, P.D. J. Neurosci. (1997) [Pubmed]
  4. Invertebrate D2 type dopamine receptor exhibits age-based plasticity of expression in the mushroom bodies of the honeybee brain. Humphries, M.A., Mustard, J.A., Hunter, S.J., Mercer, A., Ward, V., Ebert, P.R. J. Neurobiol. (2003) [Pubmed]
  5. A primordial dopamine D1-like adenylyl cyclase-linked receptor from Drosophila melanogaster displaying poor affinity for benzazepines. Sugamori, K.S., Demchyshyn, L.L., McConkey, F., Forte, M.A., Niznik, H.B. FEBS Lett. (1995) [Pubmed]
  6. Characterization of the 5' regulatory region of the Drosophila Dmdop1 dopamine receptor-gene. Kehren, V., Baumann, A. Arch. Insect Biochem. Physiol. (2005) [Pubmed]
  7. Cloning and sequence analysis of a hypothalamic cDNA encoding a D1c dopamine receptor in tilapia. Lamers, A.E., Gröneveld, D., de Kleijn, D.P., Geeraedts, F.C., Leunissen, J.A., Flik, G., Wendelaar Bonga, S.E., Martens, G.J. Biochim. Biophys. Acta (1996) [Pubmed]
  8. Role of svp in Drosophila pericardial cell growth. Yuan, W.Z., Zhang, Y.J., Tang, W.X., Wang, J., Li, Y.Q., Wang, Y.Q., Zhu, C.B., Yang, H., Wu, X.S., Rolf, B. Yi Chuan Xue Bao (2006) [Pubmed]
  9. Primary structure and functional characterization of a Drosophila dopamine receptor with high homology to human D1/5 receptors. Gotzes, F., Balfanz, S., Baumann, A. Recept. Channels (1994) [Pubmed]
  10. Cloning and functional characterization of a novel dopamine receptor from Drosophila melanogaster. Feng, G., Hannan, F., Reale, V., Hon, Y.Y., Kousky, C.T., Evans, P.D., Hall, L.M. J. Neurosci. (1996) [Pubmed]
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