High impact information on Cortactin

• Human cortactin has been identified as a protein product of a putative oncogene, EMS1 [1].
• Drosophila cortactin is a 559-amino acid protein highly expressed in embryos, larvae, and pupae but relatively underexpressed in adult flies [1].
• We find that accumulation of Cortactin protein is positively regulated by PVR [2].
• Cortactin modulates cell migration and ring canal morphogenesis during Drosophila oogenesis [2].
• Cortactin mutants also show impaired border cell migration [2].

Biological context of Cortactin

• During oogenesis, Cortactin protein is enriched at the F-actin rich ring canals in the germ line, and in migrating border cells [2].
• Mutants are viable and fertile, showing that cortactin is not an essential gene [2].
• The cytological location of the Drosophila cortactin gene is between chromosome segments 93B3 and 93B7 [3].
• Genomic organization, transcription start sites, and chromosomal location of the Drosophila cortactin gene [3].
• In this report, we describe the cloning of the Drosophila cortactin gene, which consists of four exons and three introns, covering 3 kilobases in length [3].

Anatomical context of Cortactin

• Also, overexpression of Cortactin can by itself induce F-actin accumulation and ectopic filopodia formation in epithelial cells [2].
• An actin filament binding protein cortactin was initially identified as a major phosphotyrosine-containing protein in v-Src-transformed chicken embryo fibroblast cells [3].

Physical interactions of Cortactin

• Proline-rich synapse-associated protein-1/cortactin binding protein 1 (ProSAP1/CortBP1) is a PDZ-domain protein highly enriched in the postsynaptic density [4].

Other interactions of Cortactin

• We present evidence that Cortactin is one of the factors acting downstream of PVR and Src to stimulate F-actin accumulation [2].

References