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Gene Review

Cttn  -  cortactin

Mus musculus

Synonyms: 1110020L01Rik, Ems1, Src substrate cortactin
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Disease relevance of Cttn


High impact information on Cttn

  • Cortactin, a p80-85 substrate of src- and fyn-related kinases that localizes with actin at cell adhesion sites, is increasingly tyrosine phosphorylated in calcium- and TPA-induced differentiation, with a time course which parallels that of fyn activation [5].
  • HS1, the leukocyte-specific homolog of cortactin, regulates F-actin in vitro and is phosphorylated in response to TCR ligation, but its role in lymphocyte activation has not been addressed [6].
  • Cortactin, a filamentous actin (F-actin)-associated protein and prominent substrate of Src, is implicated in progression of breast tumours through gene amplification at chromosome 11q13 [7].
  • When ligated by heparin-binding (HB) growth-associated molecule (GAM; pleiotrophin), N-syndecan mediates cortactin-Src kinase-dependent neurite outgrowth [8].
  • Furthermore, Y-->D mutation of three tyrosine residues targeted by Src (Y421, Y466, and Y482) inhibited the ability of S405,418D cortactin to activate N-WASP [9].

Chemical compound and disease context of Cttn


Biological context of Cttn


Anatomical context of Cttn


Associations of Cttn with chemical compounds


Physical interactions of Cttn


Regulatory relationships of Cttn


Other interactions of Cttn


Analytical, diagnostic and therapeutic context of Cttn


  1. Cortactin has an essential and specific role in osteoclast actin assembly. Tehrani, S., Faccio, R., Chandrasekar, I., Ross, F.P., Cooper, J.A. Mol. Biol. Cell (2006) [Pubmed]
  2. Cooperative roles of Fyn and cortactin in cell migration of metastatic murine melanoma. Huang, J., Asawa, T., Takato, T., Sakai, R. J. Biol. Chem. (2003) [Pubmed]
  3. The protein tyrosine kinase substrate cortactin is differentially expressed in murine B lymphoid tumors. Miglarese, M.R., Mannion-Henderson, J., Wu, H., Parsons, J.T., Bender, T.P. Oncogene (1994) [Pubmed]
  4. Transgenic mice with mammary gland targeted expression of human cortactin do not develop (pre-malignant) breast tumors: studies in MMTV-cortactin and MMTV-cortactin/-cyclin D1 bitransgenic mice. van Rossum, A.G., van Bragt, M.P., Schuuring-Scholtes, E., van der Ploeg, J.C., van Krieken, J.H., Kluin, P.M., Schuuring, E. BMC Cancer (2006) [Pubmed]
  5. fyn tyrosine kinase is involved in keratinocyte differentiation control. Calautti, E., Missero, C., Stein, P.L., Ezzell, R.M., Dotto, G.P. Genes Dev. (1995) [Pubmed]
  6. HS1 functions as an essential actin-regulatory adaptor protein at the immune synapse. Gomez, T.S., McCarney, S.D., Carrizosa, E., Labno, C.M., Comiskey, E.O., Nolz, J.C., Zhu, P., Freedman, B.D., Clark, M.R., Rawlings, D.J., Billadeau, D.D., Burkhardt, J.K. Immunity (2006) [Pubmed]
  7. Activation of Arp2/3 complex-mediated actin polymerization by cortactin. Uruno, T., Liu, J., Zhang, P., Fan Yx, n.u.l.l., Egile, C., Li, R., Mueller, S.C., Zhan, X. Nat. Cell Biol. (2001) [Pubmed]
  8. N-syndecan deficiency impairs neural migration in brain. Hienola, A., Tumova, S., Kulesskiy, E., Rauvala, H. J. Cell Biol. (2006) [Pubmed]
  9. Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP. Martinez-Quiles, N., Ho, H.Y., Kirschner, M.W., Ramesh, N., Geha, R.S. Mol. Cell. Biol. (2004) [Pubmed]
  10. Alternative splicing of the actin binding domain of human cortactin affects cell migration. van Rossum, A.G., de Graaf, J.H., Schuuring-Scholtes, E., Kluin, P.M., Fan, Y.X., Zhan, X., Moolenaar, W.H., Schuuring, E. J. Biol. Chem. (2003) [Pubmed]
  11. Cortactin regulates cell migration through activation of N-WASP. Kowalski, J.R., Egile, C., Gil, S., Snapper, S.B., Li, R., Thomas, S.M. J. Cell. Sci. (2005) [Pubmed]
  12. The novel dominant mutation Dspd leads to a severe spermiogenesis defect in mice. Kai, M., Irie, M., Okutsu, T., Inoue, K., Ogonuki, N., Miki, H., Yokoyama, M., Migishima, R., Muguruma, K., Fujimura, H., Kohda, T., Ogura, A., Kaneko-Ishino, T., Ishino, F. Biol. Reprod. (2004) [Pubmed]
  13. Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton. Head, J.A., Jiang, D., Li, M., Zorn, L.J., Schaefer, E.M., Parsons, J.T., Weed, S.A. Mol. Biol. Cell (2003) [Pubmed]
  14. Translocation of cortactin to the cell periphery is mediated by the small GTPase Rac1. Weed, S.A., Du, Y., Parsons, J.T. J. Cell. Sci. (1998) [Pubmed]
  15. Cell shrinkage regulates Src kinases and induces tyrosine phosphorylation of cortactin, independent of the osmotic regulation of Na+/H+ exchangers. Kapus, A., Szászi, K., Sun, J., Rizoli, S., Rotstein, O.D. J. Biol. Chem. (1999) [Pubmed]
  16. Differential regulation of cortactin and N-WASP-mediated actin polymerization by missing in metastasis (MIM) protein. Lin, J., Liu, J., Wang, Y., Zhu, J., Zhou, K., Smith, N., Zhan, X. Oncogene (2005) [Pubmed]
  17. Estrogen agonists, 17beta-estradiol, bisphenol A, and diethylstilbestrol, decrease cortactin expression in the mouse testis. Anahara, R., Yoshida, M., Toyama, Y., Maekawa, M., Kai, M., Ishino, F., Toshimori, K., Mori, C. Arch. Histol. Cytol. (2006) [Pubmed]
  18. Flutamide depresses expression of cortactin in the ectoplasmic specialization between the Sertoli cells and spermatids in the mouse testis. Anahara, R., Toyama, Y., Maekawa, M., Kai, M., Ishino, F., Toshimori, K., Mori, C. Food Chem. Toxicol. (2006) [Pubmed]
  19. A critical role for cortactin phosphorylation by Abl-family kinases in PDGF-induced dorsal-wave formation. Boyle, S.N., Michaud, G.A., Schweitzer, B., Predki, P.F., Koleske, A.J. Curr. Biol. (2007) [Pubmed]
  20. Centrosome separation driven by actin-microfilaments during mitosis is mediated by centrosome-associated tyrosine-phosphorylated cortactin. Wang, W., Chen, L., Ding, Y., Jin, J., Liao, K. J. Cell. Sci. (2008) [Pubmed]
  21. Galpha13 stimulates cell migration through cortactin-interacting protein Hax-1. Radhika, V., Onesime, D., Ha, J.H., Dhanasekaran, N. J. Biol. Chem. (2004) [Pubmed]
  22. Src is required for cell migration and shape changes induced by fibroblast growth factor 1. Liu, J., Huang, C., Zhan, X. Oncogene (1999) [Pubmed]
  23. Mice devoid of fer protein-tyrosine kinase activity are viable and fertile but display reduced cortactin phosphorylation. Craig, A.W., Zirngibl, R., Williams, K., Cole, L.A., Greer, P.A. Mol. Cell. Biol. (2001) [Pubmed]
  24. Effect of Fgd1 on cortactin in Arp2/3 complex-mediated actin assembly. Kim, K., Hou, P., Gorski, J.L., Cooper, J.A. Biochemistry (2004) [Pubmed]
  25. Down-regulation of the filamentous actin cross-linking activity of cortactin by Src-mediated tyrosine phosphorylation. Huang, C., Ni, Y., Wang, T., Gao, Y., Haudenschild, C.C., Zhan, X. J. Biol. Chem. (1997) [Pubmed]
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