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Gene Review

MOBP  -  myelin-associated oligodendrocyte basic...

Homo sapiens

Synonyms: Myelin-associated oligodendrocyte basic protein
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Disease relevance of MOBP


High impact information on MOBP


Biological context of MOBP


Anatomical context of MOBP


Associations of MOBP with chemical compounds

  • Patients received two courses of MOBP prior to and cisplatin q 3 weeks during RT [7].

Other interactions of MOBP

  • Localization by molecular modeling of a potential HLA-DRB1*1501-associated MOBP epitope within the encephalitogenic MOBP15-36 sequence suggests the potential relevance of T cell reactivity against MOBP15-36 to MS [2].

Analytical, diagnostic and therapeutic context of MOBP


  1. Myelin-associated oligodendrocytic basic protein: a family of abundant CNS myelin proteins in search of a function. Montague, P., McCallion, A.S., Davies, R.W., Griffiths, I.R. Dev. Neurosci. (2006) [Pubmed]
  2. The myelin-associated oligodendrocytic basic protein region MOBP15-36 encompasses the immunodominant major encephalitogenic epitope(s) for SJL/J mice and predicted epitope(s) for multiple sclerosis-associated HLA-DRB1*1501. de Rosbo, N.K., Kaye, J.F., Eisenstein, M., Mendel, I., Hoeftberger, R., Lassmann, H., Milo, R., Ben-Nun, A. J. Immunol. (2004) [Pubmed]
  3. Gene expression profile of the nucleus accumbens of human cocaine abusers: evidence for dysregulation of myelin. Albertson, D.N., Pruetz, B., Schmidt, C.J., Kuhn, D.M., Kapatos, G., Bannon, M.J. J. Neurochem. (2004) [Pubmed]
  4. Cytoskeletal and nuclear localization of myelin oligodendrocytic basic protein isoforms. Montague, P., Barrie, J.A., Thomson, C.E., Kirkham, D., McCallion, A.S., Davies, R.W., Kennedy, P.G., Griffths, I.R. Eur. J. Neurosci. (1998) [Pubmed]
  5. Assignment of MOBP, encoding myelin-associated oligodendrocytic basic protein, to human chromosome bands 3p22-->p21.3 using somatic cell hybrids. Gizatullin, R.Z., Protopopov, A.I., Zabarovska, V., Zakharyev, V.M., Kashuba, V.I., Klein, G., Zabarovsky, E.R. Cytogenet. Cell Genet. (1996) [Pubmed]
  6. Cloning and expression of myelin-associated oligodendrocytic basic protein. A novel basic protein constituting the central nervous system myelin. Yamamoto, Y., Mizuno, R., Nishimura, T., Ogawa, Y., Yoshikawa, H., Fujimura, H., Adachi, E., Kishimoto, T., Yanagihara, T., Sakoda, S. J. Biol. Chem. (1994) [Pubmed]
  7. A phase II trial of mitomycin, vincristine, bleomycin, and cisplatin (MOBP) as neoadjuvant therapy in high-risk cervical carcinoma. Weiner, S.A., Aristizabal, S., Alberts, D.S., Surwit, E.A., Deatherage-Deuser, K. Gynecol. Oncol. (1988) [Pubmed]
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