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Gene Review

Mobp  -  myelin-associated oligodendrocytic basic...

Mus musculus

Synonyms: AI835053, AI839848, MOBP155, MOBP170, MOBP69, ...
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Disease relevance of Mobp


Psychiatry related information on Mobp

  • These significant differences in MOBP81 and MOBP170 protein kinesis coupled to different expression profiles of their respective message populations may be indicative of both myelin structural and cellular/regulatory functions, respectively, for these polypeptides [3].

High impact information on Mobp


Biological context of Mobp


Anatomical context of Mobp


Associations of Mobp with chemical compounds

  • Surprisingly, the compact myelin was formed, however, the myelin from MOBP-deficient mice exposed to hexachlorophene, a known dysmyelinating agent, showed widening of the major dense lines [9].
  • After glutaraldehyde and tannic acid fixation, a radial series of rod-like electron enhancements in the intraperiod line in the CNS myelin, the so-called "radial component", was found arrayed in a straight radial direction in MOBP-deficient mice, while these components were scattered in an oblique zigzag direction in wild-type mice [10].

Regulatory relationships of Mobp

  • Our data suggest that incorporation of this MOBP isoform into shiverer myelin may be influenced by the presence of MBP or be a consequence of a disrupted MDL [11].

Other interactions of Mobp


Analytical, diagnostic and therapeutic context of Mobp

  • We report near complete sequence analysis of the Mobp gene (>11 kb), including complete sequence of all exons and their associated splice junctions [4].


  1. Myelin-associated oligodendrocytic basic protein: identification of an encephalitogenic epitope and association with multiple sclerosis. Holz, A., Bielekova, B., Martin, R., Oldstone, M.B. J. Immunol. (2000) [Pubmed]
  2. Encephalitogenicity of myelin-associated oligodendrocytic basic protein and 2',3'-cyclic nucleotide 3'-phosphodiesterase for BALB/c and SJL mice. Määttä, J.A., Käldman, M.S., Sakoda, S., Salmi, A.A., Hinkkanen, A.E. Immunology (1998) [Pubmed]
  3. Cytoskeletal and nuclear localization of myelin oligodendrocytic basic protein isoforms. Montague, P., Barrie, J.A., Thomson, C.E., Kirkham, D., McCallion, A.S., Davies, R.W., Kennedy, P.G., Griffths, I.R. Eur. J. Neurosci. (1998) [Pubmed]
  4. Splicing pattern, transcript start distribution, and DNA sequence of the mouse gene (Mobp) encoding myelin-associated oligodendrocytic basic protein. McCallion, A.S., Stewart, G.J., Montague, P., Griffiths, I.R., Davies, R.W. Mol. Cell. Neurosci. (1999) [Pubmed]
  5. Chromosomal localization of the myelin-associated oligodendrocytic basic protein and expression in the genetically linked neurological mouse mutants ducky and tippy. Holz, A., Frank, M., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Schwab, M.E. J. Neurochem. (1997) [Pubmed]
  6. Phenotypic analysis of mice deficient in the major myelin protein MOBP, and evidence for a novel Mobp isoform. Yool, D., Montague, P., McLaughlin, M., McCulloch, M.C., Edgar, J.M., Nave, K.A., Davies, R.W., Griffiths, I.R., McCallion, A.S. Glia (2002) [Pubmed]
  7. Characterization of the murine splice variant Mobp155: developmental CNS expression pattern and subcellular localization of epitope-tagged protein. Montague, P., McCallion, A.S., Barrie, J.E., Edgar, J.M., McLaughlin, M., Davies, R.W., Griffiths, I.R. Glia (2005) [Pubmed]
  8. Myelin-associated oligodendrocytic basic protein: a family of abundant CNS myelin proteins in search of a function. Montague, P., McCallion, A.S., Davies, R.W., Griffiths, I.R. Dev. Neurosci. (2006) [Pubmed]
  9. Myelin-associated oligodendrocytic basic protein is essential for normal arrangement of the radial component in central nervous system myelin. Yamamoto, Y., Yoshikawa, H., Nagano, S., Kondoh, G., Sadahiro, S., Gotow, T., Yanagihara, T., Sakoda, S. Eur. J. Neurosci. (1999) [Pubmed]
  10. Myelin-associated oligodendrocytic basic protein modulates the arrangement of radial growth of the axon and the radial component of myelin. Yoshikawa, H. Medical electron microscopy : official journal of the Clinical Electron Microscopy Society of Japan. (2001) [Pubmed]
  11. Reduced levels of a specific myelin-associated oligodendrocytic basic protein isoform in shiverer myelin. Montague, P., Kirkham, D., McCallion, A.S., Davies, R.W., Kennedy, P.G., Klugmann, M., Nave, K., Griffiths, I.R. Dev. Neurosci. (1999) [Pubmed]
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