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Gene Review:

CD40 - CD40 molecule, TNF receptor superfamily...

Ovis aries

Zawitkowski, M. et al., Ruth, A.J. et al., Ruth, A.J. et al., Kopf, M. et al., Osterholzer, J.J. et al., et al.

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Disease relevance of CD40

An IL-12-independent role for CD40-CD154 in mediating effector responses: studies in cell-mediated glomerulonephritis and dermal delayed-type hypersensitivity [1].

High impact information on CD40

This concurred with the observations that molecules involved in initial signaling events leading to germinal center formation were not altered (e.g., B7.2, CD40 and tumor necrosis factor R1) [2].
Most lung DC expressed CD11c, CD11b, and low levels of MHC class II, CD40, CD80, and CD86, consistent with an immature myeloid phenotype [3].
Administration of IL-12 to CD40(-/-) mice restored Th cell IFN-gamma production, and up-regulated intrarenal chemokines and glomerular T cell and macrophage accumulation compared with WT control mice [1].
The role of CD40 in the development of GN was assessed in murine experimental anti-glomerular basement membrane GN [4].
The role of CD40 expression by renal cells was assessed by comparing GN in WT-->CD40-/- chimeras (absent renal but intact bone marrow CD40) and sham chimeric mice (WT-->WT) [4].

Biological context of CD40

In addition, cDNA encompassing the extracellular region of ovine CD40 (CD40(e)) was fused 'in-frame' with the enhanced green fluorescent protein (EGFP) to generate a fusion protein upon the transfection of Chinese hamster ovary (CHO) cells [5].

Anatomical context of CD40

CD40 signalling in ileal Peyer's patch B cells: implications for T cell-dependent antigen selection [6].
Furthermore, RNA analysis confirmed expression of CD40 mRNA in both ovine dendritic cells from lymphatic drainage and dermal fibroblasts in culture [5].
The CD40 molecule is a member of the tumour necrosis factor receptor (TNFR)-like supergene family and plays a major role as a co-stimulatory molecule in the activation of T cells in response to antigens presented by dendritic cells [5].
Compared with blood counterparts, lymph monocytes expressed lower levels of CD40, and granulocytes expressed higher levels of CD80 [7].

Analytical, diagnostic and therapeutic context of CD40

Cloning and expression of the ovine CD40 molecule and the inhibition of the mixed lymphocyte reaction by the ovine CD40(e)-EGFP fusion protein [5].

References

An IL-12-independent role for CD40-CD154 in mediating effector responses: studies in cell-mediated glomerulonephritis and dermal delayed-type hypersensitivity. Ruth, A.J., Kitching, A.R., Li, M., Semple, T.J., Timoshanko, J.R., Tipping, P.G., Holdsworth, S.R. J. Immunol. (2004) [Pubmed]
Interleukin 6 influences germinal center development and antibody production via a contribution of C3 complement component. Kopf, M., Herren, S., Wiles, M.V., Pepys, M.B., Kosco-Vilbois, M.H. J. Exp. Med. (1998) [Pubmed]
CCR2 and CCR6, but not endothelial selectins, mediate the accumulation of immature dendritic cells within the lungs of mice in response to particulate antigen. Osterholzer, J.J., Ames, T., Polak, T., Sonstein, J., Moore, B.B., Chensue, S.W., Toews, G.B., Curtis, J.L. J. Immunol. (2005) [Pubmed]
Intrinsic renal cell expression of CD40 directs Th1 effectors inducing experimental crescentic glomerulonephritis. Ruth, A.J., Kitching, A.R., Semple, T.J., Tipping, P.G., Holdsworth, S.R. J. Am. Soc. Nephrol. (2003) [Pubmed]
Cloning and expression of the ovine CD40 molecule and the inhibition of the mixed lymphocyte reaction by the ovine CD40(e)-EGFP fusion protein. Zawitkowski, M., Russ, G., Krishnan, R. Vet. Immunol. Immunopathol. (2002) [Pubmed]
CD40 signalling in ileal Peyer's patch B cells: implications for T cell-dependent antigen selection. Griebel, P., Ferrari, G. Int. Immunol. (1995) [Pubmed]
Migratory monocytes and granulocytes are major lymphatic carriers of Salmonella from tissue to draining lymph node. Bonneau, M., Epardaud, M., Payot, F., Niborski, V., Thoulouze, M.I., Bernex, F., Charley, B., Riffault, S., Guilloteau, L.A., Schwartz-Cornil, I. J. Leukoc. Biol. (2006) [Pubmed]

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