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Gene Review

GLUD1  -  glutamate dehydrogenase 1

Ovis aries

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Disease relevance of LOC443239

  • The results of weight gain, parasitological and serum liver enzymes activity (glutamate dehydrogenase [GLDH] and gamma glutamyltransferase [gamma-GT]) used in monitoring the infection showed that all infected animals developed fasciolosis [1].
  • Plasma GD and gamma-GT activities are more sensitive indicators of liver cell damage in chronic subclinical fascioliasis than AST activity and gamma-GT may be more suitable as a diagnostic aid on account of its greater stability [2].

High impact information on LOC443239


Chemical compound and disease context of LOC443239


Anatomical context of LOC443239


Associations of LOC443239 with chemical compounds


Analytical, diagnostic and therapeutic context of LOC443239

  • Vaccination appeared to affect the development of the challenge fluke population, resulting in reduced hepatic damage during migration, as measured by levels of serum glutamate dehydrogenase, and an increase in mean fluke weight [14].


  1. The serum glucose and beta-hydroxybutyrate levels in sheep with experimental Fasciola hepatica and Fasciola gigantica infection. Phiri, I.K., Phiri, A.M., Harrison, L.J. Vet. Parasitol. (2007) [Pubmed]
  2. Chronic subclinical ovine fascioliasis: plasma glutamate dehydrogenase, gamma-glutamyl transpeptidase and aspartate aminotransferase activities and their significance as diagnostic aids. Sykes, A.R., Coop, R.L., Robinson, M.G. Res. Vet. Sci. (1980) [Pubmed]
  3. Activities of enzymes related to NADPH generation and amino acid metabolism in the ruminal mucosa of sheep. Weekes, T.E. J. Nutr. (1984) [Pubmed]
  4. Influence of hepatic ammonia removal on ureagenesis, amino acid utilization and energy metabolism in the ovine liver. Milano, G.D., Hotston-Moore, A., Lobley, G.E. Br. J. Nutr. (2000) [Pubmed]
  5. Hepatic detoxification of ammonia in the ovine liver: possible consequences for amino acid catabolism. Lobley, G.E., Connell, A., Lomax, M.A., Brown, D.S., Milne, E., Calder, A.G., Farningham, D.A. Br. J. Nutr. (1995) [Pubmed]
  6. Appetite depression in sheep experimentally infected with Fasciola hepatica L. Ferre, I., Barrio, J.P., Gonzalez-Gallego, J., Rojo-Vazquez, F.A. Vet. Parasitol. (1994) [Pubmed]
  7. Ovine white-liver disease (OWLD). Changes in blood chemistry. Ulvund, M.J. Acta Vet. Scand. (1990) [Pubmed]
  8. The resistance of sheep to Fasciola hepatica: studies on the pathophysiology of challenge infections. Sinclair, K.B. Res. Vet. Sci. (1975) [Pubmed]
  9. Glutamate dehydrogenase in the digestive tract of sheep. Lenártová, V., Holovská, K., Havassy, T., Boda, K. Ann. Rech. Vet. (1979) [Pubmed]
  10. Histamine and selected antihistamine regulation of glutamate dehydrogenase and acetylcholinesterase in sheep and medulla oblongata. Dikshitulu, A.V., Nandakumar, N.V., Swami, K.S. Annals of allergy. (1975) [Pubmed]
  11. Effect of early treatment with rafoxanide on antipyrine clearance in sheep infected with Fasciola hepatica. Benchaoui, H.A., McKellar, Q.A. Xenobiotica (1993) [Pubmed]
  12. Use of particle-bound microbial enzyme activity to predict the rate and extent of fibre degradation in the rumen. Silva, A.T., Wallace, R.J., Orskov, E.R. Br. J. Nutr. (1987) [Pubmed]
  13. Parenchymal injury and biliary obstruction in relation to photosensitization in sporidesmin-intoxicated lambs. Flåøyen, A., Smith, B.L. Vet. Res. Commun. (1992) [Pubmed]
  14. Attempted immunisation of sheep against Fasciola hepatica using gamma-irradiated metacercariae. Creaney, J., Spithill, T.W., Thompson, C.M., Wilson, L.R., Sandeman, R.M., Parsons, J.C. Int. J. Parasitol. (1995) [Pubmed]
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