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MYL6  -  myosin, light chain 6, alkali, smooth...

Homo sapiens

Synonyms: 17 kDa myosin light chain, ESMLC, LC17, LC17-GI, LC17-NM, ...
 
 
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Disease relevance of MYL6

 

High impact information on MYL6

  • Of 150 clones tested, three independent clones (del-27, del-118, and del-109) were identified that specifically hybridized with normal human DNA but not with tumor DNA from the cell line SK-LC-17 [1].
  • In addition, both the slow MLCs and the slow isoform of tropomyosin are expressed later in the masseter than quadriceps and the fast skeletal muscle isoform MLC3 is not detected during fetal and early postnatal development in the masseter whereas it is expressed throughout fetal development in the quadriceps [3].
  • More than half of type I fibres in both soleus (65%) and quadriceps (68%) muscles also expressed 'fast' MLC3 and 36% of the type II fibres from quadriceps muscle expressed the slow isoform of MLC2 [4].
  • The expression levels of the GM1 synthase gene showed no correlation with those of fucosyl GM1, whereas the co-transfection of GM1 synthase cDNA with FUT1 or FUT2 into SK-LC-17 clearly enhanced the neo-expression of fucosyl GM1, indicating its essential role [5].
  • The gene coding for MLC1 and MLC3 is located on human chromosome 2 [6].
 

Biological context of MYL6

 

Anatomical context of MYL6

  • We cloned the full-length cDNAs of 20 kDa regulatory myosin light chain (MLC-2) and 17 kDa essential myosin light chain (MLC-3) from Meg-01, a human megakaryoblastic leukemia cell line [8].
  • The MLC-3 protein is 99.3% identical to that of human fibroblasts [8].
  • In phasic bladder smooth muscle the exchange of LC17b for LC17a caused a significant decrease in the unloaded shortening velocity of non-phosphorylated, slowly cycling cross-bridges, suggesting that the LC17 isoforms contribute to the nucleotide affinity of latch bridges [10].
 

Associations of MYL6 with chemical compounds

  • A Bioanalytical Systems Inc. LC-17 glassy carbon oxidative flow cell with a potential held at +0.35 V vs Ag/AgCl using the LC-4A amperometric controller allowed levels of 1-2 ng/mL 5MeTHF to be measured in 500 microL of plasma [11].
 

Other interactions of MYL6

 

Analytical, diagnostic and therapeutic context of MYL6

References

  1. Isolation of DNA sequences deleted in lung cancer by genomic difference cloning. Wieland, I., Böhm, M., Bogatz, S. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  2. Increased serum myosin light chain 3 level in neuromuscular diseases. Konagaya, M., Konagaya, Y., Horikawa, H., Takayanagi, T. Muscle Nerve (1987) [Pubmed]
  3. Transition of myosin isozymes during development of human masseter muscle. Persistence of developmental isoforms during postnatal stage. Soussi-Yanicostas, N., Barbet, J.P., Laurent-Winter, C., Barton, P., Butler-Browne, G.S. Development (1990) [Pubmed]
  4. Maximum velocity of shortening in relation to myosin isoform composition in single fibres from human skeletal muscles. Larsson, L., Moss, R.L. J. Physiol. (Lond.) (1993) [Pubmed]
  5. Genetic mechanisms for the synthesis of fucosyl GM1 in small cell lung cancer cell lines. Tokuda, N., Zhang, Q., Yoshida, S., Kusunoki, S., Urano, T., Furukawa, K., Furukawa, K. Glycobiology (2006) [Pubmed]
  6. Alkali myosin light chains in man are encoded by a multigene family that includes the adult skeletal muscle, the embryonic or atrial, and nonsarcomeric isoforms. Seidel, U., Bober, E., Winter, B., Lenz, S., Lohse, P., Goedde, H.W., Grzeschik, K.H., Arnold, H.H. Gene (1988) [Pubmed]
  7. Molecular cloning and sequence of Sparus aurata skeletal myosin light chains expressed in white muscle: developmental expression and thyroid regulation. Moutou, K.A., Canario, A.V., Mamuris, Z., Power, D.M. J. Exp. Biol. (2001) [Pubmed]
  8. Molecular cloning and sequencing of myosin light chains in human megakaryoblastic leukemia cells. Watanabe, M., Kohri, M., Takaishi, M., Horie, R., Higashihara, M. Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi. (2001) [Pubmed]
  9. Regulation of nonmuscle myosin light chain 3 gene expression in response to exogenous MLC3nm mRNA. Hailstones, D., Gunning, P. Cell. Mol. Biol. Res. (1994) [Pubmed]
  10. Regulation of the cross-bridge cycle: the effects of MgADP, LC17 isoforms and telokin. Somlyo, A.V., Matthew, J.D., Wu, X., Khromov, A.S., Somlyo, A.P. Acta Physiol. Scand. (1998) [Pubmed]
  11. A rapid and specific HPLC-electrochemical method for the determination of endogenous 5-methyltetrahydrofolic acid in plasma using solid phase sample preparation with internal standardization. Lucock, M.D., Hartley, R., Smithells, R.W. Biomed. Chromatogr. (1989) [Pubmed]
 
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