High impact information on acj6

• Moreover, misexpression of Acj6 in lPNs, or Drifter in adPNs, results in dendritic targeting to glomeruli normally reserved for the other PN lineage [1].
• Acj6 also controls stereotypical axon terminal arborization of PNs in a central target, suggesting that the connectivity of PN axons and dendrites in different brain centers is coordinately regulated [1].
• I-POU: a POU-domain protein that inhibits neuron-specific gene activation [2].
• In contrast to previously published reports, the results presented here show no effect of I-POU on DNA binding by drifter, and no evidence for I-POU/drifter dimerization [3].
• These experiments provide evidence that the acj6 gene encodes a product required for olfactory signal transduction [4].

Biological context of acj6

• Choline acetyltransferase enzyme activity, protein levels, mRNA, and a fluorescent cholinergic reporter gene are all decreased in olfactory neurons of acj6 mutants [5].
• The presence of a specific Acj6 binding site has been identified in the cholinergic locus 5' flanking DNA, suggesting that Acj6 may play a direct role in specifying the cholinergic neurotransmitter phenotype of most olfactory neurons [5].

Anatomical context of acj6

• The odor specificities of a subset of olfactory receptor neurons are governed by Acj6, a POU-domain transcription factor [6].
• To further test this hypothesis, we misexpressed two Acj6 isoforms in motor neurons where they are not normally found [7].
• Loss of Acj6 function in larval optic lobe neurons results in disorganized retinal axon targeting and synapse selection [7].
• In addition to olfactory sensory neurons, Acj6 is expressed in a distinct subset of postmitotic interneurons in the central nervous system from late embryonic to adult stages [7].
• Acj6 misexpression caused marked alterations at the neuromuscular junction, with contrasting effects upon nerve terminal branching and synapse formation associated with specific Acj6 isoforms [7].

Associations of acj6 with chemical compounds

• Interestingly, abnormal chemosensory jump 6 (acj6) reduces response in the maxillary palp to all odorants tested except benzaldehyde (odor of almond), as if response to benzaldehyde is mediated through a different type of odorant pathway from the other odorants [8].

Physical interactions of acj6

• I-POU has been previously reported to inhibit DNA binding by the POU-III class factor drifter/Cf1a via the formation of heterodimeric complexes [3].

Other interactions of acj6

• Molecular analysis of acj6 shows that it encodes a POU-domain transcription factor expressed in olfactory neurons [6].

References