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Gene Review

acj6  -  abnormal chemosensory jump 6

Drosophila melanogaster

Synonyms: ACJ6, Abnormal chemosensory jump 6 protein, Acj6, CG9151, Dmel\CG9151, ...
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High impact information on acj6

  • Moreover, misexpression of Acj6 in lPNs, or Drifter in adPNs, results in dendritic targeting to glomeruli normally reserved for the other PN lineage [1].
  • Acj6 also controls stereotypical axon terminal arborization of PNs in a central target, suggesting that the connectivity of PN axons and dendrites in different brain centers is coordinately regulated [1].
  • I-POU: a POU-domain protein that inhibits neuron-specific gene activation [2].
  • In contrast to previously published reports, the results presented here show no effect of I-POU on DNA binding by drifter, and no evidence for I-POU/drifter dimerization [3].
  • These experiments provide evidence that the acj6 gene encodes a product required for olfactory signal transduction [4].

Biological context of acj6

  • Choline acetyltransferase enzyme activity, protein levels, mRNA, and a fluorescent cholinergic reporter gene are all decreased in olfactory neurons of acj6 mutants [5].
  • The presence of a specific Acj6 binding site has been identified in the cholinergic locus 5' flanking DNA, suggesting that Acj6 may play a direct role in specifying the cholinergic neurotransmitter phenotype of most olfactory neurons [5].

Anatomical context of acj6


Associations of acj6 with chemical compounds


Physical interactions of acj6

  • I-POU has been previously reported to inhibit DNA binding by the POU-III class factor drifter/Cf1a via the formation of heterodimeric complexes [3].

Other interactions of acj6

  • Molecular analysis of acj6 shows that it encodes a POU-domain transcription factor expressed in olfactory neurons [6].


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