The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Pou4f3  -  POU domain, class 4, transcription factor 3

Mus musculus

Synonyms: Brain-3C, Brain-specific homeobox/POU domain protein 3C, Brn-3.1, Brn-3C, Brn-3c, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Pou4f3


High impact information on Pou4f3


Biological context of Pou4f3


Anatomical context of Pou4f3


Associations of Pou4f3 with chemical compounds

  • Transgenic analyses have revealed the presence of hair-cell-specific promoters in the genes encoding Math1, myosin VIIa, Pou4f3, and the alpha9 subunit of the acetylcholine receptor (alpha9 AChR) [13].
  • Two other dideoxynucleosides (ddN) 2'3'-dideoxyinosine (ddl) and 2'3'-dideoxycytidine (ddC) were assessed to determine the specificity of the effect of AZT [14].
  • RESULTS: Whereas ddl had no effects, d4T, ZDV and ddC significantly decreased cellular lipid accumulation (by 32%, 46% and 24%, respectively), increased apoptosis and induced mitochondrial depolarization. d4T, ZDV and ddC decreased adipocyte mtDNA (by 64%, 53% and 46%, respectively) and reduced the mtDNA encoded COX II subunit [15].
  • METHODS: 3T3-F442A preadipocytes were exposed to stavudine (d4T; 10 microM), zidovudine (ZDV; 1 microM), zalcitabine (ddC; 0.2 microM) or didanosine (ddl; 10 microM) in the absence or presence of uridine 21 days prior to and 7 days after induction of differentiation [15].
  • METHODS: The accumulation of free and liposome-encapsulated ddl was determined in murine monocyte-macrophage RAW 264.7 cells and human premonocytoid U937 cells [16].

Other interactions of Pou4f3


Analytical, diagnostic and therapeutic context of Pou4f3


  1. All Brn3 genes can promote retinal ganglion cell differentiation in the chick. Liu, W., Khare, S.L., Liang, X., Peters, M.A., Liu, X., Cepko, C.L., Xiang, M. Development (2000) [Pubmed]
  2. Requirement for Brn-3c in maturation and survival, but not in fate determination of inner ear hair cells. Xiang, M., Gao, W.Q., Hasson, T., Shin, J.J. Development (1998) [Pubmed]
  3. Modulation of osteoclastogenesis induced by nucleoside reverse transcriptase inhibitors. Pan, G., Kilby, M., McDonald, J.M. AIDS Res. Hum. Retroviruses (2006) [Pubmed]
  4. Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development. Erkman, L., McEvilly, R.J., Luo, L., Ryan, A.K., Hooshmand, F., O'Connell, S.M., Keithley, E.M., Rapaport, D.H., Ryan, A.F., Rosenfeld, M.G. Nature (1996) [Pubmed]
  5. Evidence for vestibular regulation of autonomic functions in a mouse genetic model. Murakami, D.M., Erkman, L., Hermanson, O., Rosenfeld, M.G., Fuller, C.A. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  6. Neurovestibular modulation of circadian and homeostatic regulation: vestibulohypothalamic connection? Fuller, P.M., Jones, T.A., Jones, S.M., Fuller, C.A. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  7. Brn3c null mutant mice show long-term, incomplete retention of some afferent inner ear innervation. Xiang, M., Maklad, A., Pirvola, U., Fritzsch, B. BMC neuroscience [electronic resource]. (2003) [Pubmed]
  8. Brn-3c (POU4F3) regulates BDNF and NT-3 promoter activity. Clough, R.L., Sud, R., Davis-Silberman, N., Hertzano, R., Avraham, K.B., Holley, M., Dawson, S.J. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  9. Similarities and differences among inner retinal neurons revealed by the expression of reporter transgenes controlled by Brn-3a, Brn-3b, and Brn-3c promotor sequences. Xiang, M., Zhou, L., Nathans, J. Vis. Neurosci. (1996) [Pubmed]
  10. Transcriptional regulation by Barhl1 and Brn-3c in organ-of-Corti-derived cell lines. Sud, R., Jones, C.M., Banfi, S., Dawson, S.J. Brain Res. Mol. Brain Res. (2005) [Pubmed]
  11. Transcription profiling of inner ears from Pou4f3(ddl/ddl) identifies Gfi1 as a target of the Pou4f3 deafness gene. Hertzano, R., Montcouquiol, M., Rashi-Elkeles, S., Elkon, R., Yücel, R., Frankel, W.N., Rechavi, G., Möröy, T., Friedman, T.B., Kelley, M.W., Avraham, K.B. Hum. Mol. Genet. (2004) [Pubmed]
  12. Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth. Wang, S.W., Mu, X., Bowers, W.J., Kim, D.S., Plas, D.J., Crair, M.C., Federoff, H.J., Gan, L., Klein, W.H. Development (2002) [Pubmed]
  13. Transgenic and gene targeting studies of hair cell function in mouse inner ear. Zuo, J. J. Neurobiol. (2002) [Pubmed]
  14. Regulation of megakaryocyte colony forming cell numbers and ploidy by dideoxynucleosides in immunodeficient mice. Chow, F.P., Ordóñez, J.V., Sutton, P.A., Hamburger, A.W. Am. J. Hematol. (1993) [Pubmed]
  15. Uridine abrogates the adverse effects of antiretroviral pyrimidine analogues on adipose cell functions. Walker, U.A., Auclair, M., Lebrecht, D., Kornprobst, M., Capeau, J., Caron, M. Antivir. Ther. (Lond.) (2006) [Pubmed]
  16. Antiviral efficacy, intracellular uptake and pharmacokinetics of free and liposome-encapsulated 2',3'-dideoxyinosine. Désormeaux, A., Harvie, P., Perron, S., Makabi-Panzu, B., Beauchamp, D., Tremblay, M., Poulin, L., Bergeron, M.G. AIDS (1994) [Pubmed]
  17. Mutant mice reveal the molecular and cellular basis for specific sensory connections to inner ear epithelia and primary nuclei of the brain. Fritzsch, B., Pauley, S., Matei, V., Katz, D.M., Xiang, M., Tessarollo, L. Hear. Res. (2005) [Pubmed]
  18. The development of the vertebrate inner ear. Torres, M., Giráldez, F. Mech. Dev. (1998) [Pubmed]
  19. Differentiation of mammalian vestibular hair cells from conditionally immortal, postnatal supporting cells. Lawlor, P., Marcotti, W., Rivolta, M.N., Kros, C.J., Holley, M.C. J. Neurosci. (1999) [Pubmed]
  20. Identification of differentiating cochlear hair cells in vitro. Weir, J., Rivolta, M., Holley, M. The American journal of otology. (2000) [Pubmed]
WikiGenes - Universities