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Gene Review

IL3  -  interleukin 3 (colony-stimulating factor,...

Canis lupus familiaris

Synonyms: IL-3, MCGF
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High impact information on IL3


Biological context of IL3

  • Canine IL-3 cDNA includes a single open reading frame of 432 nucleotides, which encodes a 143 amino acid polypeptide and has 44.7, 42.4, 37 and 23.7% homology with the cow, sheep, human and rat IL-3 sequences, respectively [5].
  • In the studies reviewed here, we investigated the effects of rhu-EPO and IL-3 on perioperative erythropoiesis in two canine models of acute isovolemic hemodilution [6].

Anatomical context of IL3


  1. Mast cell expression of gelatinases A and B is regulated by kit ligand and TGF-beta. Fang, K.C., Wolters, P.J., Steinhoff, M., Bidgol, A., Blount, J.L., Caughey, G.H. J. Immunol. (1999) [Pubmed]
  2. Growth-dependent accumulation of monoalkylglycerol in Madin-Darby canine kidney cells. Evidence for a role in the regulation of protein kinase C. Warne, T.R., Buchanan, F.G., Robinson, M. J. Biol. Chem. (1995) [Pubmed]
  3. Enrichment and characterization of peripheral blood-derived megakaryocyte progenitors that mature in short-term liquid culture. Nichol, J.L., Hornkohl, A.C., Choi, E.S., Hokom, M.M., Ponting, I., Schuening, F.W., Hunt, P. Stem Cells (1994) [Pubmed]
  4. Use of recombinant canine granulocyte colony-stimulating factor to decrease myelosuppression associated with the administration of mitoxantrone in the dog. Ogilvie, G.K., Obradovich, J.E., Cooper, M.F., Walters, L.M., Salman, M.D., Boone, T.C. J. Vet. Intern. Med. (1992) [Pubmed]
  5. Studies of cocktail therapy with multiple cytokines for neoplasia or infectious disease of the dog I. cDNA cloning of canine IL-3 and IL-6. Shin, I.S., Kim, H.R., Nam, M.J., Youn, H.Y. J. Vet. Sci. (2001) [Pubmed]
  6. Optimizing autologous blood donation by recombinant human erythropoietin (rhu-EPO) and interleukin 3 (IL-3). Krieter, H., Frey, L., Segiet, W., Brückner, U.B., Krumwieh, D., Seiler, F.R., Messmer, K. Behring Inst. Mitt. (1991) [Pubmed]
  7. Myelopoiesis and myeloproliferative disorders. Raskin, R.E. Vet. Clin. North Am. Small Anim. Pract. (1996) [Pubmed]
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