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Gene Review

PODXL2  -  podocalyxin-like 2

Homo sapiens

Synonyms: EG, Endoglycan, PODLX2, Podocalyxin-like protein 2, UNQ1861/PRO3742, ...
 
 
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Disease relevance of PODXL2

  • The aim of our study was to investigate the fibrinolytic system in a group of healthy controls and vascular disease patients, before and after endoglycan administration "per os". All the patients had a reduced basal fibrinolytic activity [1].
 

High impact information on PODXL2

  • Low force decelerates L-selectin dissociation from P-selectin glycoprotein ligand-1 and endoglycan [2].
  • These catch-slip transitional bonds were also observed for L-selectin interacting with endoglycan, a newly identified PSGL-1-like ligand [2].
  • Endoglycan, a member of the CD34 family, functions as an L-selectin ligand through modification with tyrosine sulfation and sialyl Lewis x [3].
  • Since the distribution of endoglycan includes hematopoietic precursors and leukocyte subpopulations, in addition to endothelial cells, our findings suggest several potential settings for endoglycan-mediated adhesion events [3].
  • However, endoglycan employs a different binding mechanism, interacting with L-selectin through sulfation on two tyrosine residues and O-linked sLex structures that are presented within its highly acidic amino-terminal region [3].
 

Biological context of PODXL2

 

Anatomical context of PODXL2

 

Associations of PODXL2 with chemical compounds

References

  1. Fibrinolytic effect of a particular glycosaminoglycan (endoglycan) per os on normals and in patients with chronic artery disease. Patrassi, G.M., Veronesi, A., Sartori, M.T., Viero, M.L., Boeri, G., Girolami, A. Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. (1990) [Pubmed]
  2. Low force decelerates L-selectin dissociation from P-selectin glycoprotein ligand-1 and endoglycan. Sarangapani, K.K., Yago, T., Klopocki, A.G., Lawrence, M.B., Fieger, C.B., Rosen, S.D., McEver, R.P., Zhu, C. J. Biol. Chem. (2004) [Pubmed]
  3. Endoglycan, a member of the CD34 family, functions as an L-selectin ligand through modification with tyrosine sulfation and sialyl Lewis x. Fieger, C.B., Sassetti, C.M., Rosen, S.D. J. Biol. Chem. (2003) [Pubmed]
  4. Identification of endoglycan, a member of the CD34/podocalyxin family of sialomucins. Sassetti, C., Van Zante, A., Rosen, S.D. J. Biol. Chem. (2000) [Pubmed]
  5. Beyond mere markers: functions for CD34 family of sialomucins in hematopoiesis. Furness, S.G., McNagny, K. Immunol. Res. (2006) [Pubmed]
  6. Podocalyxin in human haematopoietic cells. Kerosuo, L., Juvonen, E., Alitalo, R., Gylling, M., Kerjaschki, D., Miettinen, A. Br. J. Haematol. (2004) [Pubmed]
 
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