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Gene Review

ACP5  -  acid phosphatase 5, tartrate resistant

Homo sapiens

Synonyms: SPENCDI, TR-AP, TRAP, Tartrate-resistant acid ATPase, Tartrate-resistant acid phosphatase type 5, ...
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Disease relevance of ACP5

  • Northern blotting techniques employing a labeled TR-AP cDNA probe revealed the presence of a 1.5-kilobase transcript in white cells from a patient with hairy cell leukemia, in human K562 erythroleukemic cells, and in Epstein-Barr virus-transformed human B-cells, but not in a human T-cell line [1].
  • On closer examination, a high significance of ACP5 repression was suggested in the cirrhotic HCC subgroup that was derived from chronic hepatitis B infected patients (55%; 30/54 cases; p = 0.001) [2].

High impact information on ACP5

  • In vitro promoter analyses identified nuclear factor of activated T-cells (NFAT)/AP-1 sites in the osteoclast-specific Acp5 and Calcr promoters [3].
  • The deduced amino acid sequence of the human TR-AP is 85% identical to that of porcine uteroferrin (whose sequence is also reported here in complete form for the first time) and 82% identical to the corresponding regions of a partial amino acid sequence of a bovine spleen phosphoprotein phosphatase [1].
  • Culture of K562 cells in presence of 10(-8) M phorbol 12-myristate 13-acetate ester for 48-72 h enhanced TR-AP activity per cell about 30-fold and led to a corresponding increase in TR-AP mRNA levels [1].
  • When a placental lambda gt11 cDNA library was screened with two short 32P-labeled cDNA clones from within the coding region of uteroferrin, a 1412-base pair cDNA was identified that encodes the entire human TR-AP isozyme [1].
  • A corresponding transcriptional mapping by cDNA array on 19p suggested the differential expression of a single downregulated gene ACP5 (tartrate-resistant acid phosphatase type 5) [2].

Biological context of ACP5


Anatomical context of ACP5

  • Quantitative RT-PCR confirmed the reduced expression of ACP5 and indicated a strong correlation of its repressed expression only in cell lines that contain a 19p rearrangement (p = 0.004) [2].
  • METHODS: We transfected the human ACP 5 gene into CHO cells and cloned a stable cell line (CHO/TRACP 8F5) that expresses high levels of TRACP activity both intracellularly and as a secreted product [6].

Other interactions of ACP5


  1. Molecular cloning of the type 5, iron-containing, tartrate-resistant acid phosphatase from human placenta. Ketcham, C.M., Roberts, R.M., Simmen, R.C., Nick, H.S. J. Biol. Chem. (1989) [Pubmed]
  2. Transcriptional profiling on chromosome 19p indicated frequent downregulation of ACP5 expression in hepatocellular carcinoma. Chan, K.Y., Wong, N., Lai, P.B., Squire, J.A., Macgregor, P.F., Beheshti, B., Albert, M., To, K.F., Johnson, P.J. Int. J. Cancer (2005) [Pubmed]
  3. Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-Fos. Matsuo, K., Galson, D.L., Zhao, C., Peng, L., Laplace, C., Wang, K.Z., Bachler, M.A., Amano, H., Aburatani, H., Ishikawa, H., Wagner, E.F. J. Biol. Chem. (2004) [Pubmed]
  4. Confirmation of the assignment of the human tartrate-resistant acid phosphatase gene (ACP5) to chromosome 19. Leach, R.J., Reus, B.E., Hundley, J.E., Johnson-Pais, T.L., Windle, J.J. Genomics (1994) [Pubmed]
  5. Localization of the human type 5, tartrate-resistant acid phosphatase gene by in situ hybridization. Allen, B.S., Ketcham, C.M., Roberts, R.M., Nick, H.S., Ostrer, H. Genomics (1989) [Pubmed]
  6. Stable expression of human tartrate-resistant acid phosphatase isoforms by CHO cells. Janckila, A.J., Parthasarathy, R.N., Parthasarathy, L.K., Seelan, R.S., Yam, L.T. Clin. Chim. Acta (2002) [Pubmed]
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