Disease relevance of DSAP1

• The first locus for DSAP was localized to chromosome 12q23.2-24.1, but no gene responsible for porokeratosis has been identified to date [1].
• Squamous cell carcinoma in disseminated superficial actinic porokeratosis [2].
• In sun-damaged skin of Australians disseminated superficial actinic porokeratosis is commonly mistaken for solar keratosis [3].
• RESULTS--Three types of skin reaction were noted: generalized, erythematous, maculopapular eruption (10 patients); keratoacanthoma (two patients); and disseminated superficial actinic porokeratosis (one patient) [4].
• Induction of disseminated superficial actinic porokeratosis by phototherapy for psoriasis [5].

High impact information on DSAP1

• Identification of a locus for disseminated superficial actinic porokeratosis at chromosome 12q23.2-24.1 [6].
• The fine mapping study indicates that the disseminated superficial actinic porokeratosis gene is located within a 9.6 cM region between markers D12S1727 and D12S1605, with a maximum two-point LOD score of 20.53 (theta = 0.00) at D12S78 [6].
• Glucoprivation caused a significant reduction in sex behavior in both SAP and DSAP animals equally, compared to saline treatments (p < 0.05) [7].
• Insulin-induced hypoglycemia did not increase AVP levels in either DSAP- or SAP-treated rats [8].
• As was expected, the DSAP-treated rats showed decreased feeding during glucoprivation (250 mg/kg 2-deoxy-D-glucose, 2DG) compared to SAP controls [7].

Chemical compound and disease context of DSAP1

• The immunosuppressive effect of suramin may induce the keratoacanthoma and disseminated superficial actinic porokeratosis lesions [4].
• We report a patient with disseminated superficial actinic porokeratosis (DSAP) who developed digitate keratoses following treatment with etretinate [9].
• We report a case of a patient with disseminated superficial actinic porokeratosis displaying a comparable inflammatory process following therapy with systemic 5-fluorouracil used to manage a metastatic breast cancer [10].

Biological context of DSAP1

• CONCLUSIONS: The DSAP1 locus was localized to a 4.4-cM interval at chromosome 12q23.2-24 [11].
• Fine mapping and haplotype construction refined the DSAP1 locus to a 4.4-cM interval [11].
• However, the same dose of insulin increased food intake and corticosterone secretion in SAP controls, and these responses were profoundly impaired by DSAP [8].
• To elucidate the morphogenesis of cornoid lamellae (CL) in porokeratosis, skin lesions of three cases of disseminated superficial actinic porokeratosis and a case of linear porokeratosis were examined [12].
• LOH would also explain the early age of presentation of the linear lesions, the family history of DSAP, and why LP cases are particularly prone to malignant transformation [13].

Anatomical context of DSAP1

• RESULTS: The cytotoxic and apoptotic response to UVB or X-irradiation was similar in DSAP-derived keratinocytes and fibroblasts when compared with normal cells [14].
• Reconstructed epidermis and reconstructed skin models successfully reproduced the main features of this genodermatosis, showing that DSAP-derived keratinocytes bear an inherent defect in the terminal differentiation programme [14].
• Our patient's eruption of DSAP highlights a little recognized cutaneous manifestation of aggressive bone marrow transplant induction therapy [15].
• We report a 62-year-old man who developed DSAP in a widely and rapidly progressive manner within days of receiving total body radiation and high-dose induction chemotherapy as planned preparative therapy for an autologous peripheral blood stem cell transplant for relapsed high grade lymphoma [15].
• Two closely linked variations in actin cytoskeleton pathway in a Chinese pedigree with disseminated superficial actinic porokeratosis [16].

Associations of DSAP1 with chemical compounds

• Treatment of disseminated superficial actinic porokeratosis with a new aromatic retinoid (Ro 10-9359) [17].
• Disseminated superficial actinic porokeratosis: treatment with topical tacalcitol [18].
• To determine if this pathway is involved in the regulation of sex behavior and luteinizing hormone (LH) secretion, this catecholaminergic pathway was lesioned with injections of saporin conjugated with anti-dopamine-beta-hydroxylase (DSAP) or unconjugated saporin (SAP) in adult male rats [7].
• Successful treatment of disseminated superficial actinic porokeratosis with methyl aminolevulinate-photodynamic therapy [19].
• Disseminated superficial actinic porokeratosis responding to calcipotriol [20].

Other interactions of DSAP1

• A novel locus (DSAP2) for disseminated superficial actinic porokeratosis maps to chromosome 15q25.1-26.1 [1].
• Fine mapping and identification of a candidate gene SSH1 in disseminated superficial actinic porokeratosis [21].
• A mutation in SART3 gene in a Chinese pedigree with disseminated superficial actinic porokeratosis [22].
• A strategy for approaching the problem of the invisible dermatoses is to first examine the epidermis for fungi, cornoid lamellae (disseminated superficial actinic porokeratosis), and absence of the granular layer (dominant ichthyosis vulgaris) [23].
• Disseminated superficial actinic porokeratosis in a patient with systemic lupus erythematosus [24].

Analytical, diagnostic and therapeutic context of DSAP1

• Disseminated superficial actinic porokeratosis: appearance associated with photochemotherapy for psoriasis [25].
• Dermoscopy of disseminated superficial actinic porokeratosis [26].
• Scanning electron microscopy of disseminated superficial actinic porokeratosis [27].
• A case of disseminated superficial actinic porokeratosis subsequent to renal transplantation [28].
• Immunosuppression is recognized to predispose to the development of disseminated superficial actinic porokeratosis and to cause the spread of pre-existing lesions [29].

References