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Chemical Compound Review

Monosodium urate     sodium6,8-dioxo-7,9-dihydro- 3H-purin-2-olate

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Disease relevance of uric acid


High impact information on uric acid

  • Both MSU and CPPD increased the secretion of IL-8 by neutrophils in a dose- and time-dependent manner, but had no effect on that of MIP-1 alpha [2].
  • These LPS did not enhance platelet stimulation by antiplatelet antibody, monosodium urate crystals, or thrombin and only slightly enhanced stimulation by insoluble human skin collagen [6].
  • These findings prompt questions concerning how the innate immune system recognizes MSU and the identities of the receptors involved [7].
  • Overall, these results demonstrate that colchicine specifically and significantly inhibits the protein tyrosine phosphorylation induced by MSU and CPPD crystals and suggest that its effects are associated, at least in part, with its interaction with microtubules [8].
  • Factors that modulate the ability of monosodium urate crystals to stimulate leukocytes could regulate gouty inflammation [9].

Chemical compound and disease context of uric acid


Biological context of uric acid


Anatomical context of uric acid


Associations of uric acid with other chemical compounds


Gene context of uric acid


Analytical, diagnostic and therapeutic context of uric acid


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  3. Mechanism for calcium urolithiasis among patients with hyperuricosuria: supersaturation of urine with respect to monosodium urate. Pak, C.Y., Waters, O., Arnold, L., Holt, K., Cox, C., Barilla, D. J. Clin. Invest. (1977) [Pubmed]
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  9. Apolipoprotein (apo) E inhibits the capacity of monosodium urate crystals to stimulate neutrophils. Characterization of intraarticular apo E and demonstration of apo E binding to urate crystals in vivo. Terkeltaub, R.A., Dyer, C.A., Martin, J., Curtiss, L.K. J. Clin. Invest. (1991) [Pubmed]
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  15. Immunoglobulin G independent activation of the classical complement pathway by monosodium urate crystals. Giclas, P.C., Ginsberg, M.H., Cooper, N.R. J. Clin. Invest. (1979) [Pubmed]
  16. Isolation of a collagenase cDNA clone and measurement of changing collagenase mRNA levels during induction in rabbit synovial fibroblasts. Gross, R.H., Sheldon, L.A., Fletcher, C.F., Brinckerhoff, C.E. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  17. Noninflammatory phagocytosis of monosodium urate monohydrate crystals by mouse macrophages. Implications for the control of joint inflammation in gout. Yagnik, D.R., Hillyer, P., Marshall, D., Smythe, C.D., Krausz, T., Haskard, D.O., Landis, R.C. Arthritis Rheum. (2000) [Pubmed]
  18. Crystal-induced neutrophil activation. I. Initiation and modulation of calcium mobilization and superoxide production by microcrystals. Naccache, P.H., Grimard, M., Roberge, C.J., Gilbert, C., Lussier, A., de Médicis, R., Poubelle, P.E. Arthritis Rheum. (1991) [Pubmed]
  19. Plasma protein binding by monosodium urate crystals. Analysis by two-dimensional gel electrophoresis. Terkeltaub, R., Tenner, A.J., Kozin, F., Ginsberg, M.H. Arthritis Rheum. (1983) [Pubmed]
  20. Urate crystals stimulate production of tumor necrosis factor alpha from human blood monocytes and synovial cells. Cytokine mRNA and protein kinetics, and cellular distribution. di Giovine, F.S., Malawista, S.E., Thornton, E., Duff, G.W. J. Clin. Invest. (1991) [Pubmed]
  21. Identification of pathological mineral deposits by Raman microscopy. McGill, N., Dieppe, P.A., Bowden, M., Gardiner, D.J., Hall, M. Lancet (1991) [Pubmed]
  22. Synovial fluid analysis for diagnosis of intercritical gout. Pascual, E., Batlle-Gualda, E., Martínez, A., Rosas, J., Vela, P. Ann. Intern. Med. (1999) [Pubmed]
  23. Crystal-induced neutrophil activation VI. Involvment of FcgammaRIIIB (CD16) and CD11b in response to inflammatory microcrystals. Barabé, F., Gilbert, C., Liao, N., Bourgoin, S.G., Naccache, P.H. FASEB J. (1998) [Pubmed]
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  32. TLR2 signaling in chondrocytes drives calcium pyrophosphate dihydrate and monosodium urate crystal-induced nitric oxide generation. Liu-Bryan, R., Pritzker, K., Firestein, G.S., Terkeltaub, R. J. Immunol. (2005) [Pubmed]
  33. Monosodium urate-crystal-stimulated phospholipase D in human neutrophils. Marcil, J., Harbour, D., Houle, M.G., Naccache, P.H., Bourgoin, S. Biochem. J. (1999) [Pubmed]
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  35. Evidence for a role for SAM68 in the responses of human neutrophils to ligation of CD32 and to monosodium urate crystals. Gilbert, C., Barabé, F., Rollet-Labelle, E., Bourgoin, S.G., McColl, S.R., Damaj, B.B., Naccache, P.H. J. Immunol. (2001) [Pubmed]
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