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Gene Review

RASIP1  -  Ras interacting protein 1

Homo sapiens

Synonyms: FLJ20401, RAIN, Rain, Ras-interacting protein 1
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Disease relevance of RASIP1

  • Pathogenesis of myiasis due to the muscid fly Philornis deceptivus in nestling pearly-eyed thrashers (Margarops fuscatus) in the Luquillo Rain Forest, Puerto Rico was investigated [1].
  • The majority were young adults with no ocular complications suggesting the Rain Forest type of African onchocerciasis [2].
  • In this paper we will attempt to answer the question, "What is Yellow Rain?", summarize some of the massive data on microtoxins and mycotoxicoses, discuss the toxicology of the trichothecenes, give a brief historical perspective on chemical warfare, and touch on some of the political implications of these developments [3].

High impact information on RASIP1


Biological context of RASIP1


Analytical, diagnostic and therapeutic context of RASIP1

  • The protein-protein interaction map of H. pylori, which is based on a high-throughput two-hybrid screen (Rain et al., 2001. Nature 409, 211-215) indicated a protein-protein interaction between the gene product of ORF hp137 and both the histidine kinase HP244 and the flagellar hook protein HP908 [10].


  1. Pathogenesis associated with philornid myiasis (Diptera: Muscidae) on nestling pearly-eyed thrashers (Aves: Mimidae) in the Luquillo Rain Forest, Puerto Rico. Uhazy, L.S., Arendt, W.J. J. Wildl. Dis. (1986) [Pubmed]
  2. Onchocerciasis in Nigeria: observations on the geographical basis of the endemicity in Lagos. Hunponu-Wusu, O.O., Somorin, A.O. The Journal of tropical medicine and hygiene. (1977) [Pubmed]
  3. Yellow rain: chemical warfare in Southeast Asia and Afghanistan. Spyker, M.S., Spyker, D.A. Veterinary and human toxicology. (1983) [Pubmed]
  4. Neurobiology. Rain Man's revelations. Birbaumer, N. Nature (1999) [Pubmed]
  5. The Bcr kinase downregulates Ras signaling by phosphorylating AF-6 and binding to its PDZ domain. Radziwill, G., Erdmann, R.A., Margelisch, U., Moelling, K. Mol. Cell. Biol. (2003) [Pubmed]
  6. A novel Ras-interacting protein required for chemotaxis and cyclic adenosine monophosphate signal relay in Dictyostelium. Lee, S., Parent, C.A., Insall, R., Firtel, R.A. Mol. Biol. Cell (1999) [Pubmed]
  7. Interpretation of atypical patterns encountered when using a flow cytometry-based method to detect residual leukocytes in leukoreduced red blood cell components. Janatpour, K., Paglieroni, T.G., Schuller, L., Foley, K., Rizzardo, T., Holland, P.V. Cytometry. (2002) [Pubmed]
  8. Pesticides in rainwater in Flanders, Belgium: results from the monitoring program 1997-2001. Quaghebeur, D., De Smet, B., De Wulf, E., Steurbaut, W. Journal of environmental monitoring : JEM. (2004) [Pubmed]
  9. Global warming. Rain might be leading carbon sink factor. Lovett, R.A. Science (2002) [Pubmed]
  10. Protein-protein interaction of HP137 with histidine kinase HP244 does not contribute to flagellar regulation in Helicobacter pylori. Jiménez-Pearson, M.A., Dietz, P., Beier, D. Microbiol. Res. (2005) [Pubmed]
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