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Chemical Compound Review

Dichlofos     1,1-dichloro-2- dimethoxyphosphoryloxy-ethene

Synonyms: Astrobot, Brevinyl, Divipan, Novotox, dichlorvos, ...
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Disease relevance of Dichlorophos


Psychiatry related information on Dichlorophos

  • Effects of an organophosphate (dichlorvos) on open field behavior and locomotor activity: correlation with regional brain monoamine levels [6].
  • In the other two tests, active avoidance learning and rotarod performance, the effective dose of dichlorvos (2 mg/kg) was devoid of somatic signs of intoxication [7].
  • Feeding behavior and brain acetylcholinesterase activity in bream (Abramis brama L.) as affected by DDVP, an organophosphorus insecticide [8].

High impact information on Dichlorophos


Chemical compound and disease context of Dichlorophos


Biological context of Dichlorophos


Anatomical context of Dichlorophos


Associations of Dichlorophos with other chemical compounds

  • Acylpeptide hydrolase was found to be potently inhibited by the organophosphorus compounds chlorpyrifosmethyl oxon, dichlorvos, and diisopropylfluorophosphate (20-min IC(50) values of 18.3 +/- 2.0, 118.7 +/- 9.7, and 22.5 +/- 1.2 nM, respectively) [10].
  • The insecticides dichlorvos, Landrin, pyrethrum, Sevin, malathion, and Diazinon significantly (P = 0.05) inhibited production of aflatoxins at a 100-ppm concentration [26].
  • In cell-free experiments using the cytosol of Aspergillus parasiticus NIAH-26, both (2'S)- and (2'R)-VOAc enantiomers were formed at about a 1:2 ratio from racemic VHA in the presence of NADPH and dichlorvos (dimethyl 2,2-dichlorovinylphosphate) [27].
  • These increases in calpain activity and in the levels of intracellular Ca(2+) were not observed when nimodipine was administered to rats treated with dichlorvos [1].
  • We report high-performance liquid chromatographic methods using ultraviolet detection, developed for the first time in our laboratory with sensitivity to detect clinically significant concentrations of metrifonate (MTF), an experimental drug for Alzheimer disease, and its active anticholinesterase metabolite, dichlorvos (DDVP) [28].

Gene context of Dichlorophos


Analytical, diagnostic and therapeutic context of Dichlorophos

  • Flow-injection and biosensor conditions were optimised, then the system was evaluated by monitoring the model organophosphate pesticides (OP) dichlorvos and paraoxon [33].
  • INTERVENTIONS: Fasting mice were administered 57.5 mg/kg of a 0.55% dichlorvos solution via feeding tube [34].
  • An electrochemical bioassay for dichlorvos analysis in durum wheat samples [35].
  • Electromyographic (EMG) examinations were performed on Beagles before and for 7 days after oral administration of one of the following organophosphate (OP) compounds; ronnel (55.0 or 110.0 mg/kg), dichlorvos (29.7, 59.4, or 148.5 mg/kg), or cythioate (24.8 or 33.0 mg/kg) [36].
  • Two methods for the determination of dichlorvos in durum wheat by electrochemical assay and gas chromatography, respectively, have been developed [37].


  1. Protective effect of nimodipine on dichlorvos-induced delayed neurotoxicity in rat brain(1). Choudhary, S., Gill, K.D. Biochem. Pharmacol. (2001) [Pubmed]
  2. International Commission for Protection against Environmental Mutagens and Carcinogens. ICPEMC publication No. 5: An evaluation of the genetic toxicity of dichlorvos. Ramel, C., Drake, J., Sugimura, T. Mutat. Res. (1980) [Pubmed]
  3. Prenatal exposure to dichlorvos: physical and behavioral effects on rat offspring. Lazarini, C.A., Lima, R.Y., Guedes, A.P., Bernardi, M.M. Neurotoxicology and teratology. (2004) [Pubmed]
  4. Microbiological mutagenicity studies of pesticides in vitro. Carere, A., Ortali, V.A., Cardamone, G., Torracca, A.M., Raschetti, R. Mutat. Res. (1978) [Pubmed]
  5. The resistance of E. coli cultivated in low concentrations of dichlorvos to N-methyl-N'-nitro-N-nitrosoguanidine induced mutagenesis. Alldrick, A.J., Rowland, I.R. Mutat. Res. (1985) [Pubmed]
  6. Effects of an organophosphate (dichlorvos) on open field behavior and locomotor activity: correlation with regional brain monoamine levels. Ali, S.F., Chandra, O., Hasan, M. Psychopharmacology (Berl.) (1980) [Pubmed]
  7. The influence of diazepam on atropine reversal of behavioural impairment in dichlorvos-treated rats. Savić, M.M., Obradović, D.I., Ugresić, N.D., Bokonjić, D.R. Pharmacol. Toxicol. (2003) [Pubmed]
  8. Feeding behavior and brain acetylcholinesterase activity in bream (Abramis brama L.) as affected by DDVP, an organophosphorus insecticide. Pavlov, D.D., Chuiko, G.M., Gerassimov, Y.V., Tonkopiy, V.D. Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. (1992) [Pubmed]
  9. Inhibition of monocyte esterase activity by organophosphate insecticides. Lee, M.J., Waters, H.C. Blood (1977) [Pubmed]
  10. Identification of acylpeptide hydrolase as a sensitive site for reaction with organophosphorus compounds and a potential target for cognitive enhancing drugs. Richards, P.G., Johnson, M.K., Ray, D.E. Mol. Pharmacol. (2000) [Pubmed]
  11. Characterization of organophosphate interactions at N-methyl-D-aspartate receptors in brain synaptic membranes. Johnson, P.S., Michaelis, E.K. Mol. Pharmacol. (1992) [Pubmed]
  12. Fractal analysis of Daphnia motion for acute toxicity bioassay. Shimizu, N., Ogino, C., Kawanishi, T., Hayashi, Y. Environ. Toxicol. (2002) [Pubmed]
  13. Characterisation of cholinesterases and evaluation of the inhibitory potential of chlorpyrifos and dichlorvos to Artemia salina and Artemia parthenogenetica. Varó, I., Navarro, J.C., Amat, F., Guilhermino, L. Chemosphere (2002) [Pubmed]
  14. Drug interactions of levamisole with pyrantel tartrate and dichlorvos in pigs. Hsu, W.H. Am. J. Vet. Res. (1981) [Pubmed]
  15. Mortality and LC50 values for several stages of the marine copepod Tigriopus brevicornis (Müller) exposed to the metals arsenic and cadmium and the pesticides atrazine, carbofuran, dichlorvos, and malathion. Forget, J., Pavillon, J.F., Menasria, M.R., Bocquené, G. Ecotoxicol. Environ. Saf. (1998) [Pubmed]
  16. Changes in toxicity of DDVP, DFP, and parathion in rats under cold environment. Chattopadhyay, D.P., Dighe, S.K., Dube, D.K., Purnanand, n.u.l.l. Bulletin of environmental contamination and toxicology. (1982) [Pubmed]
  17. Progressive deficit of retrograde axonal transport is associated with the pathogenesis of di-n-butyl dichlorvos axonopathy. Moretto, A., Lotti, M., Sabri, M.I., Spencer, P.S. J. Neurochem. (1987) [Pubmed]
  18. Human serum "A"-esterases. Hydrolysis of O,O-dimethyl-2,2-dichlorovinyl phosphate. Traverso, R., Moretto, A., Lotti, M. Biochem. Pharmacol. (1989) [Pubmed]
  19. Activity of cholinesterases in the Japanese quail embryo. Effects of dichlorphos on the embryonic development. Kaltner, H., Andrae, S., Wittmann, J. Biochem. Pharmacol. (1993) [Pubmed]
  20. The distribution of dichlorvos in the tissues of mammals after its inhalation or intravenous administration. Blair, D., Hoadley, C., Hutson, D.H. Toxicol. Appl. Pharmacol. (1975) [Pubmed]
  21. Enzymatic conversion of averufin to hydroxyversicolorone and elucidation of a novel metabolic grid involved in aflatoxin biosynthesis. Yabe, K., Chihaya, N., Hamamatsu, S., Sakuno, E., Hamasaki, T., Nakajima, H., Bennett, J.W. Appl. Environ. Microbiol. (2003) [Pubmed]
  22. Latent dichlorvos neurotoxicity detected by vagal tone monitoring in dogs. Dellinger, J.A., McKiernan, B.C., Koritz, G.D., Richardson, B.C. Neurotoxicology and teratology. (1987) [Pubmed]
  23. Possible role of enhanced microtubule phosphorylation in dichlorvos induced delayed neurotoxicity in rat. Choudhary, S., Joshi, K., Gill, K.D. Brain Res. (2001) [Pubmed]
  24. Carcinogenesis studies of dichlorvos in Fischer rats and B6C3F1 mice. Chan, P.C., Huff, J., Haseman, J.K., Alison, R., Prejean, J.D. Jpn. J. Cancer Res. (1991) [Pubmed]
  25. Dissociation of DDVP-induced DNA strand breaks from oxidative damage in isolated rat hepatocytes. Yamano, T. Toxicology (1996) [Pubmed]
  26. Inhibition of aflatoxin production by selected insecticides. Draughon, F.A., Ayres, J.C. Appl. Environ. Microbiol. (1981) [Pubmed]
  27. Stereochemistry during aflatoxin biosynthesis: cyclase reaction in the conversion of versiconal to versicolorin B and racemization of versiconal hemiacetal acetate. Yabe, K., Hamasaki, T. Appl. Environ. Microbiol. (1993) [Pubmed]
  28. High-performance liquid chromatographic method using ultraviolet detection for measuring metrifonate and dichlorvos levels in human plasma. Unni, L.K., Hannant, M.E., Becker, R.E. J. Chromatogr. (1992) [Pubmed]
  29. Effects of currently used pesticides in assays for estrogenicity, androgenicity, and aromatase activity in vitro. Andersen, H.R., Vinggaard, A.M., Rasmussen, T.H., Gjermandsen, I.M., Bonefeld-Jørgensen, E.C. Toxicol. Appl. Pharmacol. (2002) [Pubmed]
  30. The effect of food and time of administration on the pharmacokinetic and pharmacodynamic profile of metrifonate. Heinig, R., Sachse, R. International journal of clinical pharmacology and therapeutics. (1999) [Pubmed]
  31. Active site mutant acetylcholinesterase interactions with 2-PAM, HI-6, and DDVP. Kovarik, Z., Ciban, N., Radić, Z., Simeon-Rudolf, V., Taylor, P. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  32. Blood acylpeptide hydrolase activity is a sensitive marker for exposure to some organophosphate toxicants. Quistad, G.B., Klintenberg, R., Casida, J.E. Toxicol. Sci. (2005) [Pubmed]
  33. Flow-injection detector incorporating a screen-printed disposable amperometric biosensor for monitoring organophosphate pesticides. Rippeth, J.J., Gibson, T.D., Hart, J.P., Hartley, I.C., Nelson, G. The Analyst. (1997) [Pubmed]
  34. Prevention of oral dichlorvos toxicity by different activated charcoal products in mice. Tuncok, Y., Gelal, A., Apaydin, S., Guven, H., Fowler, J., Gure, A. Annals of emergency medicine. (1995) [Pubmed]
  35. An electrochemical bioassay for dichlorvos analysis in durum wheat samples. Del Carlo, M., Pepe, A., De Gregorio, M., Mascini, M., Marty, J.L., Fournier, D., Visconti, A., Compagnone, D. J. Food Prot. (2006) [Pubmed]
  36. Motor unit irritability in Beagles Before and after exposure to cholinesterase inhibitors. Hazelwood, J.C., Stefan, G.E., Bowen, J.M. Am. J. Vet. Res. (1979) [Pubmed]
  37. Use of electrochemical biosensor and gas chromatography for determination of dichlorvos in wheat. Longobardi, F., Solfrizzo, M., Compagnone, D., Del Carlo, M., Visconti, A. J. Agric. Food Chem. (2005) [Pubmed]
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