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Gene Review

IL17RB  -  interleukin 17 receptor B

Homo sapiens

Synonyms: CRL4, Cytokine receptor-like 4, EVI27, IL-17 receptor B, IL-17 receptor homolog 1, ...
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Disease relevance of IL17RB

  • Murine EVI27 was identified through its location at a common site of retroviral integration in BXH2 murine myeloid leukemias [1].
  • PURPOSE We previously identified three genes, HOXB13, IL17BR and CHDH, and the HOXB13:IL17BR ratio index in particular, that strongly predicted clinical outcome in breast cancer patients receiving tamoxifen monotherapy [2].

High impact information on IL17RB

  • IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1 [1].
  • In the mouse, highest Evi27 expression occurs in liver and testes with lower expression in kidney and lung [3].
  • Northern and Western analysis showed that Evi27 is expressed in selected T-cell, B-cell and myeloid cell lines [3].
  • The human EVI27 homolog was also cloned and mapped to chromosome 3p21 [3].
  • METHODS: Expression of IL-17B receptor (IL-17BR), a receptor for IL-17E, was evaluated by immunofluorescent staining, Western blot, and real-time PCR in human primary lung fibroblasts [4].

Biological context of IL17RB


Associations of IL17RB with chemical compounds


Other interactions of IL17RB

  • Whereas IL-17R expression increased upon in vitro stimulation with IL-17, expression of IL-17RB, C and D was unchanged [8].
  • We detected transcripts of IL-17R, as well as those of IL-17RB, C and D, in the FLSs of RA patients [8].

Analytical, diagnostic and therapeutic context of IL17RB


  1. IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1. Lee, J., Ho, W.H., Maruoka, M., Corpuz, R.T., Baldwin, D.T., Foster, J.S., Goddard, A.D., Yansura, D.G., Vandlen, R.L., Wood, W.I., Gurney, A.L. J. Biol. Chem. (2001) [Pubmed]
  2. The HOXB13:IL17BR Expression Index Is a Prognostic Factor in Early-Stage Breast Cancer. Ma, X.J., Hilsenbeck, S.G., Wang, W., Ding, L., Sgroi, D.C., Bender, R.A., Osborne, C.K., Allred, D.C., Erlander, M.G. J. Clin. Oncol. (2006) [Pubmed]
  3. Evi27 encodes a novel membrane protein with homology to the IL17 receptor. Tian, E., Sawyer, J.R., Largaespada, D.A., Jenkins, N.A., Copeland, N.G., Shaughnessy, J.D. Oncogene (2000) [Pubmed]
  4. IL-17E upregulates the expression of proinflammatory cytokines in lung fibroblasts. Létuvé, S., Lajoie-Kadoch, S., Audusseau, S., Rothenberg, M.E., Fiset, P.O., Ludwig, M.S., Hamid, Q. J. Allergy Clin. Immunol. (2006) [Pubmed]
  5. A two-gene expression ratio of homeobox 13 and interleukin-17B receptor for prediction of recurrence and survival in women receiving adjuvant tamoxifen. Goetz, M.P., Suman, V.J., Ingle, J.N., Nibbe, A.M., Visscher, D.W., Reynolds, C.A., Lingle, W.L., Erlander, M., Ma, X.J., Sgroi, D.C., Perez, E.A., Couch, F.J. Clin. Cancer Res. (2006) [Pubmed]
  6. Limits of predictive models using microarray data for breast cancer clinical treatment outcome. Reid, J.F., Lusa, L., De Cecco, L., Coradini, D., Veneroni, S., Daidone, M.G., Gariboldi, M., Pierotti, M.A. J. Natl. Cancer Inst. (2005) [Pubmed]
  7. Cytochrome P450 2D6 and homeobox 13/interleukin-17B receptor: combining inherited and tumor gene markers for prediction of tamoxifen resistance. Goetz, M.P., Suman, V.J., Couch, F.J., Ames, M.M., Rae, J.M., Erlander, M.G., Ma, X.J., Sgroi, D.C., Reynolds, C.A., Lingle, W.L., Weinshilboum, R.M., Flockhart, D.A., Desta, Z., Perez, E.A., Ingle, J.N. Clin. Cancer Res. (2008) [Pubmed]
  8. Expression of IL-17 homologs and their receptors in the synovial cells of rheumatoid arthritis patients. Hwang, S.Y., Kim, H.Y. Mol. Cells (2005) [Pubmed]
  9. Transgenic overexpression of human IL-17E results in eosinophilia, B-lymphocyte hyperplasia, and altered antibody production. Kim, M.R., Manoukian, R., Yeh, R., Silbiger, S.M., Danilenko, D.M., Scully, S., Sun, J., DeRose, M.L., Stolina, M., Chang, D., Van, G.Y., Clarkin, K., Nguyen, H.Q., Yu, Y.B., Jing, S., Senaldi, G., Elliott, G., Medlock, E.S. Blood (2002) [Pubmed]
  10. A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen. Ma, X.J., Wang, Z., Ryan, P.D., Isakoff, S.J., Barmettler, A., Fuller, A., Muir, B., Mohapatra, G., Salunga, R., Tuggle, J.T., Tran, Y., Tran, D., Tassin, A., Amon, P., Wang, W., Wang, W., Enright, E., Stecker, K., Estepa-Sabal, E., Smith, B., Younger, J., Balis, U., Michaelson, J., Bhan, A., Habin, K., Baer, T.M., Brugge, J., Haber, D.A., Erlander, M.G., Sgroi, D.C. Cancer Cell (2004) [Pubmed]
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