The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

CENPJ  -  centromere protein J

Homo sapiens

Synonyms: BM032, CENP-J, CPAP, Centromere protein J, Centrosomal P4.1-associated protein, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CENPJ


High impact information on CENPJ


Biological context of CENPJ


Associations of CENPJ with chemical compounds


Other interactions of CENPJ

  • The underlying genes for two of these were recently identified as CDK5RAP2 and CENPJ [4].
  • Using the LAG-3 intracytoplasmic region as bait in the yeast two-hybrid cloning system, we next identified a novel protein termed LAP for LAG-3-associated protein [9].
  • It is a genetically heterogeneous disorder with six known loci: MCPH1 to MCPH6 [10].

Analytical, diagnostic and therapeutic context of CENPJ

  • Indirect immunofluorescence and cellular fractionation studies revealed that CPAP was predominantly cytoplasmic, with low levels in the nucleus [1].
  • After treatment with TNFalpha, a portion of CPAP was observed to accumulate in the nucleus, although CPAP was found primarily in the cytoplasm without any stimulation [7].



  1. CPAP is a novel stat5-interacting cofactor that augments stat5-mediated transcriptional activity. Peng, B., Sutherland, K.D., Sum, E.Y., Olayioye, M., Wittlin, S., Tang, T.K., Lindeman, G.J., Visvader, J.E. Mol. Endocrinol. (2002) [Pubmed]
  2. Two peptides derived from the nerve growth factor precursor are biologically active. Dicou, E., Pflug, B., Magazin, M., Lehy, T., Djakiew, D., Ferrara, P., Nerrière, V., Harvie, D. J. Cell Biol. (1997) [Pubmed]
  3. Protein 4.1 R-135 interacts with a novel centrosomal protein (CPAP) which is associated with the gamma-tubulin complex. Hung, L.Y., Tang, C.J., Tang, T.K. Mol. Cell. Biol. (2000) [Pubmed]
  4. Molecular evolution of the brain size regulator genes CDK5RAP2 and CENPJ. Evans, P.D., Vallender, E.J., Lahn, B.T. Gene (2006) [Pubmed]
  5. A novel deletion mutation in CENPJ gene in a Pakistani family with autosomal recessive primary microcephaly. Gul, A., Hassan, M.J., Hussain, S., Raza, S.I., Chishti, M.S., Ahmad, W. J. Hum. Genet. (2006) [Pubmed]
  6. Identification of a novel microtubule-destabilizing motif in CPAP that binds to tubulin heterodimers and inhibits microtubule assembly. Hung, L.Y., Chen, H.L., Chang, C.W., Li, B.R., Tang, T.K. Mol. Biol. Cell (2004) [Pubmed]
  7. Centrosomal P4.1-associated protein is a new member of transcriptional coactivators for nuclear factor-kappaB. Koyanagi, M., Hijikata, M., Watashi, K., Masui, O., Shimotohno, K. J. Biol. Chem. (2005) [Pubmed]
  8. CPAP interacts with 14-3-3 in a cell cycle-dependent manner. Chen, C.Y., Olayioye, M.A., Lindeman, G.J., Tang, T.K. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  9. LAP, a lymphocyte activation gene-3 (LAG-3)-associated protein that binds to a repeated EP motif in the intracellular region of LAG-3, may participate in the down-regulation of the CD3/TCR activation pathway. Iouzalen, N., Andreae, S., Hannier, S., Triebel, F. Eur. J. Immunol. (2001) [Pubmed]
  10. Genetic analysis of primary microcephaly in Indian families: novel ASPM mutations. Kumar, A., Blanton, S.H., Babu, M., Markandaya, M., Girimaji, S.C. Clin. Genet. (2004) [Pubmed]
WikiGenes - Universities