Gene Review:
GSK1 - glycogen synthase kinase 1
Homo sapiens
This record was discontinued.
Li,
Friedman,
Zhu,
Wang,
Boswell,
May,
Davis,
Jope,
Pastorino,
Hoek,
Shulga,
Fishman,
Madi,
Bar-Yehuda,
Barer,
Del Valle,
Khalili,
Desbois-Mouthon,
Blivet-Van Eggelpoël,
Beurel,
Boissan,
Delélo,
Cadoret,
Capeau,
Meijer,
Flajolet,
Greengard,
Gong,
Rifai,
Dworkin,
Hong,
Chen,
Cheng,
Howng,
Chow,
Preece,
Virley,
Costandi,
Coombes,
Moss,
Mudge,
Jazin,
Cairns,
Wittmann,
Waterman-Storer,
- Reciprocal targeting of Hath1 and beta-catenin by Wnt glycogen synthase kinase 3beta in human colon cancer. Tsuchiya, K., Nakamura, T., Okamoto, R., Kanai, T., Watanabe, M. Gastroenterology (2007)
- Dysregulation of glycogen synthase kinase-3beta signaling in hepatocellular carcinoma cells. Desbois-Mouthon, C., Blivet-Van Eggelpoël, M.J., Beurel, E., Boissan, M., Delélo, R., Cadoret, A., Capeau, J. Hepatology (2002)
- Frequent somatic mutations of the beta-catenin gene in intestinal-type gastric cancer. Park, W.S., Oh, R.R., Park, J.Y., Lee, S.H., Shin, M.S., Kim, Y.S., Kim, S.Y., Lee, H.K., Kim, P.J., Oh, S.T., Yoo, N.J., Lee, J.Y. Cancer Res. (1999)
- Membrane depolarization induces the undulating phosphorylation/dephosphorylation of glycogen synthase kinase 3beta, and this dephosphorylation involves protein phosphatases 2A and 2B in SH-SY5Y human neuroblastoma cells. Lee, Y.I., Seo, M., Kim, Y., Kim, S.Y., Kang, U.G., Kim, Y.S., Juhnn, Y.S. J. Biol. Chem. (2005)
- Diabetes Abolishes Morphine-Induced Cardioprotection via Multiple Pathways Upstream of Glycogen Synthase Kinase-3{beta}. Gross, E.R., Hsu, A.K., Gross, G.J. Diabetes (2007)
- Lithium regulates glycogen synthase kinase-3beta in human peripheral blood mononuclear cells: implication in the treatment of bipolar disorder. Li, X., Friedman, A.B., Zhu, W., Wang, L., Boswell, S., May, R.S., Davis, L.L., Jope, R.S. Biol. Psychiatry (2007)
- Glycogen synthase kinase 3beta and Alzheimer's disease: pathophysiological and therapeutic significance. Balaraman, Y., Limaye, A.R., Levey, A.I., Srinivasan, S. Cell. Mol. Life Sci. (2006)
- Dominant feminizing mutations implicate protein-protein interactions as the main mode of regulation of the nematode sex-determining gene tra-1. de Bono, M., Zarkower, D., Hodgkin, J. Genes Dev. (1995)
- Spatial regulation of CLASP affinity for microtubules by Rac1 and GSK3beta in migrating epithelial cells. Wittmann, T., Waterman-Storer, C.M. J. Cell Biol. (2005)
- Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex. Dajani, R., Fraser, E., Roe, S.M., Yeo, M., Good, V.M., Thompson, V., Dale, T.C., Pearl, L.H. EMBO J. (2003)
- A yeast model system for functional analysis of beta-catenin signaling. Lee, M.S., D'Amour, K.A., Papkoff, J. J. Cell Biol. (2002)
- An inactive pool of GSK-3 at the leading edge of growth cones is implicated in Semaphorin 3A signaling. Eickholt, B.J., Walsh, F.S., Doherty, P. J. Cell Biol. (2002)
- Evidence for involvement of Wnt signaling pathway in IB-MECA mediated suppression of melanoma cells. Fishman, P., Madi, L., Bar-Yehuda, S., Barer, F., Del Valle, L., Khalili, K. Oncogene (2002)
- Glycogen synthase kinase 3 alpha and 3 beta do not colocalize with neurofibrillary tangles. Harr, S.D., Hollister, R.D., Hyman, B.T. Neurobiol. Aging (1996)
- Oxidant-mediated Akt Activation in Human RPE Cells. Yang, P., Peairs, J.J., Tano, R., Jaffe, G.J. Invest. Ophthalmol. Vis. Sci. (2006)
- Lithium activates mammalian Na+/H+ exchangers: isoform specificity and inhibition by genistein. Kobayashi, Y., Pang, T., Iwamoto, T., Wakabayashi, S., Shigekawa, M. Pflugers Arch. (2000)
- Mechanisms linking diabetes mellitus to the development of atherosclerosis: a role for endoplasmic reticulum stress and glycogen synthase kinase-3. Robertson, L.A., Kim, A.J., Werstuck, G.H. Can. J. Physiol. Pharmacol. (2006)
- Pharmacological inhibitors of glycogen synthase kinase 3. Meijer, L., Flajolet, M., Greengard, P. Trends Pharmacol. Sci. (2004)
- Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling. Riobó, N.A., Lu, K., Ai, X., Haines, G.M., Emerson, C.P. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Glycogen synthase kinase 3 and h-prune regulate cell migration by modulating focal adhesions. Kobayashi, T., Hino, S., Oue, N., Asahara, T., Zollo, M., Yasui, W., Kikuchi, A. Mol. Cell. Biol. (2006)
- Inhibition of glycogen synthase kinase 3beta suppresses coxsackievirus-induced cytopathic effect and apoptosis via stabilization of beta-catenin. Yuan, J., Zhang, J., Wong, B.W., Si, X., Wong, J., Yang, D., Luo, H. Cell Death Differ. (2005)
- Role of glycogen synthase kinase 3beta in rapamycin-mediated cell cycle regulation and chemosensitivity. Dong, J., Peng, J., Zhang, H., Mondesire, W.H., Jian, W., Mills, G.B., Hung, M.C., Meric-Bernstam, F. Cancer Res. (2005)
- KLHL1/MRP2 Mediates Neurite Outgrowth in a Glycogen Synthase Kinase 3{beta}-Dependent Manner. Seng, S., Avraham, H.K., Jiang, S., Venkatesh, S., Avraham, S. Mol. Cell. Biol. (2006)
- Endoplasmic reticulum stress accelerates p53 degradation by the cooperative actions of Hdm2 and glycogen synthase kinase 3beta. Pluquet, O., Qu, L.K., Baltzis, D., Koromilas, A.E. Mol. Cell. Biol. (2005)
- Roles of Akt and glycogen synthase kinase 3beta in the ultraviolet B induction of cyclooxygenase-2 transcription in human keratinocytes. Tang, Q., Gonzales, M., Inoue, H., Bowden, G.T. Cancer Res. (2001)
- Activation of glycogen synthase kinase 3beta disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytotoxicity. Pastorino, J.G., Hoek, J.B., Shulga, N. Cancer Res. (2005)
- Inhibition of glycogen synthase kinase 3 improves insulin action and glucose metabolism in human skeletal muscle. Nikoulina, S.E., Ciaraldi, T.P., Mudaliar, S., Carter, L., Johnson, K., Henry, R.R. Diabetes (2002)
- Selective interaction between leptin and insulin signaling pathways in a hepatic cell line. Szanto, I., Kahn, C.R. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Jun is phosphorylated by several protein kinases at the same sites that are modified in serum-stimulated fibroblasts. Baker, S.J., Kerppola, T.K., Luk, D., Vandenberg, M.T., Marshak, D.R., Curran, T., Abate, C. Mol. Cell. Biol. (1992)
- Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway. Fang, X., Yu, S., Tanyi, J.L., Lu, Y., Woodgett, J.R., Mills, G.B. Mol. Cell. Biol. (2002)
- Retinoic acid receptors inhibit AP1 activation by regulating extracellular signal-regulated kinase and CBP recruitment to an AP1-responsive promoter. Benkoussa, M., Brand, C., Delmotte, M.H., Formstecher, P., Lefebvre, P. Mol. Cell. Biol. (2002)
- Regulation of glycogen synthesis by amino acids in cultured human muscle cells. Armstrong, J.L., Bonavaud, S.M., Toole, B.J., Yeaman, S.J. J. Biol. Chem. (2001)
- Human dynamin-like protein interacts with the glycogen synthase kinase 3beta. Hong, Y.R., Chen, C.H., Cheng, D.S., Howng, S.L., Chow, C.C. Biochem. Biophys. Res. Commun. (1998)
- Notch 1 overexpression inhibits osteoblastogenesis by suppressing Wnt/beta-catenin but not bone morphogenetic protein signaling. Deregowski, V., Gazzerro, E., Priest, L., Rydziel, S., Canalis, E. J. Biol. Chem. (2006)
- The low density lipoprotein receptor-related protein 6 interacts with glycogen synthase kinase 3 and attenuates activity. Mi, K., Dolan, P.J., Johnson, G.V. J. Biol. Chem. (2006)
- Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis. Castellone, M.D., Teramoto, H., Williams, B.O., Druey, K.M., Gutkind, J.S. Science (2005)
- Glycogen synthase kinase 3 phosphorylates RBL2/p130 during quiescence. Litovchick, L., Chestukhin, A., DeCaprio, J.A. Mol. Cell. Biol. (2004)
- MUC1 oncoprotein blocks glycogen synthase kinase 3beta-mediated phosphorylation and degradation of beta-catenin. Huang, L., Chen, D., Liu, D., Yin, L., Kharbanda, S., Kufe, D. Cancer Res. (2005)
- Phosphatidylinositol 3-kinase and glycogen synthase kinase 3 regulate estrogen receptor-mediated transcription in neuronal cells. Mendez, P., Garcia-Segura, L.M. Endocrinology (2006)
- The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation. Welcker, M., Orian, A., Jin, J., Grim, J.E., Grim, J.A., Harper, J.W., Eisenman, R.N., Clurman, B.E. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Identification of an N-terminal glycogen synthase kinase 3 phosphorylation site which regulates the functional localization of polycystin-2 in vivo and in vitro. Streets, A.J., Moon, D.J., Kane, M.E., Obara, T., Ong, A.C. Hum. Mol. Genet. (2006)
- Cripto-1 induces phosphatidylinositol 3'-kinase-dependent phosphorylation of AKT and glycogen synthase kinase 3beta in human cervical carcinoma cells. Ebert, A.D., Wechselberger, C., Frank, S., Wallace-Jones, B., Seno, M., Martinez-Lacaci, I., Bianco, C., De Santis, M., Weitzel, H.K., Salomon, D.S. Cancer Res. (1999)
- Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-catenin. Li, Y., Bharti, A., Chen, D., Gong, J., Kufe, D. Mol. Cell. Biol. (1998)
- Wnt-1 but not epidermal growth factor induces beta-catenin/T-cell factor-dependent transcription in esophageal cancer cells. Mizushima, T., Nakagawa, H., Kamberov, Y.G., Wilder, E.L., Klein, P.S., Rustgi, A.K. Cancer Res. (2002)
- Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells. Hajduch, E., Alessi, D.R., Hemmings, B.A., Hundal, H.S. Diabetes (1998)
- Overexpression of NBS1 contributes to transformation through the activation of phosphatidylinositol 3-kinase/Akt. Chen, Y.C., Su, Y.N., Chou, P.C., Chiang, W.C., Chang, M.C., Wang, L.S., Teng, S.C., Wu, K.J. J. Biol. Chem. (2005)
- Beta-parvin inhibits integrin-linked kinase signaling and is downregulated in breast cancer. Mongroo, P.S., Johnstone, C.N., Naruszewicz, I., Leung-Hagesteijn, C., Sung, R.K., Carnio, L., Rustgi, A.K., Hannigan, G.E. Oncogene (2004)
- Hepatocyte growth factor suppresses acute renal inflammation by inhibition of endothelial E-selectin. Gong, R., Rifai, A., Dworkin, L.D. Kidney Int. (2006)
- Effects of glycogen synthase kinase 3beta and cyclin-dependent kinase 5 inhibitors on morphine-induced analgesia and tolerance in rats. Parkitna, J.R., Obara, I., Wawrzczak-Bargiela, A., Makuch, W., Przewlocka, B., Przewlocki, R. J. Pharmacol. Exp. Ther. (2006)
- Beta-secretase (BACE) and GSK-3 mRNA levels in Alzheimer's disease. Preece, P., Virley, D.J., Costandi, M., Coombes, R., Moss, S.J., Mudge, A.W., Jazin, E., Cairns, N.J. Brain Res. Mol. Brain Res. (2003)
- Increased tau phosphorylation but absence of formation of neurofibrillary tangles in mice double transgenic for human tau and Alzheimer mutant (M146L) presenilin-1. Boutajangout, A., Leroy, K., Touchet, N., Authelet, M., Blanchard, V., Tremp, G., Pradier, L., Brion, J.P. Neurosci. Lett. (2002)