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Gene Review

GSK1  -  glycogen synthase kinase 1

Homo sapiens

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Disease relevance of GSK1


Psychiatry related information on GSK1


High impact information on GSK1


Chemical compound and disease context of GSK1


Biological context of GSK1


Anatomical context of GSK1


Associations of GSK1 with chemical compounds


Physical interactions of GSK1


Enzymatic interactions of GSK1


Regulatory relationships of GSK1


Other interactions of GSK1


Analytical, diagnostic and therapeutic context of GSK1


  1. Reciprocal targeting of Hath1 and beta-catenin by Wnt glycogen synthase kinase 3beta in human colon cancer. Tsuchiya, K., Nakamura, T., Okamoto, R., Kanai, T., Watanabe, M. Gastroenterology (2007) [Pubmed]
  2. Dysregulation of glycogen synthase kinase-3beta signaling in hepatocellular carcinoma cells. Desbois-Mouthon, C., Blivet-Van Eggelpoël, M.J., Beurel, E., Boissan, M., Delélo, R., Cadoret, A., Capeau, J. Hepatology (2002) [Pubmed]
  3. Frequent somatic mutations of the beta-catenin gene in intestinal-type gastric cancer. Park, W.S., Oh, R.R., Park, J.Y., Lee, S.H., Shin, M.S., Kim, Y.S., Kim, S.Y., Lee, H.K., Kim, P.J., Oh, S.T., Yoo, N.J., Lee, J.Y. Cancer Res. (1999) [Pubmed]
  4. Membrane depolarization induces the undulating phosphorylation/dephosphorylation of glycogen synthase kinase 3beta, and this dephosphorylation involves protein phosphatases 2A and 2B in SH-SY5Y human neuroblastoma cells. Lee, Y.I., Seo, M., Kim, Y., Kim, S.Y., Kang, U.G., Kim, Y.S., Juhnn, Y.S. J. Biol. Chem. (2005) [Pubmed]
  5. Diabetes Abolishes Morphine-Induced Cardioprotection via Multiple Pathways Upstream of Glycogen Synthase Kinase-3{beta}. Gross, E.R., Hsu, A.K., Gross, G.J. Diabetes (2007) [Pubmed]
  6. Lithium regulates glycogen synthase kinase-3beta in human peripheral blood mononuclear cells: implication in the treatment of bipolar disorder. Li, X., Friedman, A.B., Zhu, W., Wang, L., Boswell, S., May, R.S., Davis, L.L., Jope, R.S. Biol. Psychiatry (2007) [Pubmed]
  7. Glycogen synthase kinase 3beta and Alzheimer's disease: pathophysiological and therapeutic significance. Balaraman, Y., Limaye, A.R., Levey, A.I., Srinivasan, S. Cell. Mol. Life Sci. (2006) [Pubmed]
  8. Dominant feminizing mutations implicate protein-protein interactions as the main mode of regulation of the nematode sex-determining gene tra-1. de Bono, M., Zarkower, D., Hodgkin, J. Genes Dev. (1995) [Pubmed]
  9. Spatial regulation of CLASP affinity for microtubules by Rac1 and GSK3beta in migrating epithelial cells. Wittmann, T., Waterman-Storer, C.M. J. Cell Biol. (2005) [Pubmed]
  10. Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex. Dajani, R., Fraser, E., Roe, S.M., Yeo, M., Good, V.M., Thompson, V., Dale, T.C., Pearl, L.H. EMBO J. (2003) [Pubmed]
  11. A yeast model system for functional analysis of beta-catenin signaling. Lee, M.S., D'Amour, K.A., Papkoff, J. J. Cell Biol. (2002) [Pubmed]
  12. An inactive pool of GSK-3 at the leading edge of growth cones is implicated in Semaphorin 3A signaling. Eickholt, B.J., Walsh, F.S., Doherty, P. J. Cell Biol. (2002) [Pubmed]
  13. Evidence for involvement of Wnt signaling pathway in IB-MECA mediated suppression of melanoma cells. Fishman, P., Madi, L., Bar-Yehuda, S., Barer, F., Del Valle, L., Khalili, K. Oncogene (2002) [Pubmed]
  14. Glycogen synthase kinase 3 alpha and 3 beta do not colocalize with neurofibrillary tangles. Harr, S.D., Hollister, R.D., Hyman, B.T. Neurobiol. Aging (1996) [Pubmed]
  15. Oxidant-mediated Akt Activation in Human RPE Cells. Yang, P., Peairs, J.J., Tano, R., Jaffe, G.J. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  16. Lithium activates mammalian Na+/H+ exchangers: isoform specificity and inhibition by genistein. Kobayashi, Y., Pang, T., Iwamoto, T., Wakabayashi, S., Shigekawa, M. Pflugers Arch. (2000) [Pubmed]
  17. Mechanisms linking diabetes mellitus to the development of atherosclerosis: a role for endoplasmic reticulum stress and glycogen synthase kinase-3. Robertson, L.A., Kim, A.J., Werstuck, G.H. Can. J. Physiol. Pharmacol. (2006) [Pubmed]
  18. Pharmacological inhibitors of glycogen synthase kinase 3. Meijer, L., Flajolet, M., Greengard, P. Trends Pharmacol. Sci. (2004) [Pubmed]
  19. Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling. Riobó, N.A., Lu, K., Ai, X., Haines, G.M., Emerson, C.P. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  20. Glycogen synthase kinase 3 and h-prune regulate cell migration by modulating focal adhesions. Kobayashi, T., Hino, S., Oue, N., Asahara, T., Zollo, M., Yasui, W., Kikuchi, A. Mol. Cell. Biol. (2006) [Pubmed]
  21. Inhibition of glycogen synthase kinase 3beta suppresses coxsackievirus-induced cytopathic effect and apoptosis via stabilization of beta-catenin. Yuan, J., Zhang, J., Wong, B.W., Si, X., Wong, J., Yang, D., Luo, H. Cell Death Differ. (2005) [Pubmed]
  22. Role of glycogen synthase kinase 3beta in rapamycin-mediated cell cycle regulation and chemosensitivity. Dong, J., Peng, J., Zhang, H., Mondesire, W.H., Jian, W., Mills, G.B., Hung, M.C., Meric-Bernstam, F. Cancer Res. (2005) [Pubmed]
  23. KLHL1/MRP2 Mediates Neurite Outgrowth in a Glycogen Synthase Kinase 3{beta}-Dependent Manner. Seng, S., Avraham, H.K., Jiang, S., Venkatesh, S., Avraham, S. Mol. Cell. Biol. (2006) [Pubmed]
  24. Endoplasmic reticulum stress accelerates p53 degradation by the cooperative actions of Hdm2 and glycogen synthase kinase 3beta. Pluquet, O., Qu, L.K., Baltzis, D., Koromilas, A.E. Mol. Cell. Biol. (2005) [Pubmed]
  25. Roles of Akt and glycogen synthase kinase 3beta in the ultraviolet B induction of cyclooxygenase-2 transcription in human keratinocytes. Tang, Q., Gonzales, M., Inoue, H., Bowden, G.T. Cancer Res. (2001) [Pubmed]
  26. Activation of glycogen synthase kinase 3beta disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytotoxicity. Pastorino, J.G., Hoek, J.B., Shulga, N. Cancer Res. (2005) [Pubmed]
  27. Inhibition of glycogen synthase kinase 3 improves insulin action and glucose metabolism in human skeletal muscle. Nikoulina, S.E., Ciaraldi, T.P., Mudaliar, S., Carter, L., Johnson, K., Henry, R.R. Diabetes (2002) [Pubmed]
  28. Selective interaction between leptin and insulin signaling pathways in a hepatic cell line. Szanto, I., Kahn, C.R. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  29. Jun is phosphorylated by several protein kinases at the same sites that are modified in serum-stimulated fibroblasts. Baker, S.J., Kerppola, T.K., Luk, D., Vandenberg, M.T., Marshak, D.R., Curran, T., Abate, C. Mol. Cell. Biol. (1992) [Pubmed]
  30. Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway. Fang, X., Yu, S., Tanyi, J.L., Lu, Y., Woodgett, J.R., Mills, G.B. Mol. Cell. Biol. (2002) [Pubmed]
  31. Retinoic acid receptors inhibit AP1 activation by regulating extracellular signal-regulated kinase and CBP recruitment to an AP1-responsive promoter. Benkoussa, M., Brand, C., Delmotte, M.H., Formstecher, P., Lefebvre, P. Mol. Cell. Biol. (2002) [Pubmed]
  32. Regulation of glycogen synthesis by amino acids in cultured human muscle cells. Armstrong, J.L., Bonavaud, S.M., Toole, B.J., Yeaman, S.J. J. Biol. Chem. (2001) [Pubmed]
  33. Human dynamin-like protein interacts with the glycogen synthase kinase 3beta. Hong, Y.R., Chen, C.H., Cheng, D.S., Howng, S.L., Chow, C.C. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  34. Notch 1 overexpression inhibits osteoblastogenesis by suppressing Wnt/beta-catenin but not bone morphogenetic protein signaling. Deregowski, V., Gazzerro, E., Priest, L., Rydziel, S., Canalis, E. J. Biol. Chem. (2006) [Pubmed]
  35. The low density lipoprotein receptor-related protein 6 interacts with glycogen synthase kinase 3 and attenuates activity. Mi, K., Dolan, P.J., Johnson, G.V. J. Biol. Chem. (2006) [Pubmed]
  36. Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis. Castellone, M.D., Teramoto, H., Williams, B.O., Druey, K.M., Gutkind, J.S. Science (2005) [Pubmed]
  37. Glycogen synthase kinase 3 phosphorylates RBL2/p130 during quiescence. Litovchick, L., Chestukhin, A., DeCaprio, J.A. Mol. Cell. Biol. (2004) [Pubmed]
  38. MUC1 oncoprotein blocks glycogen synthase kinase 3beta-mediated phosphorylation and degradation of beta-catenin. Huang, L., Chen, D., Liu, D., Yin, L., Kharbanda, S., Kufe, D. Cancer Res. (2005) [Pubmed]
  39. Phosphatidylinositol 3-kinase and glycogen synthase kinase 3 regulate estrogen receptor-mediated transcription in neuronal cells. Mendez, P., Garcia-Segura, L.M. Endocrinology (2006) [Pubmed]
  40. The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation. Welcker, M., Orian, A., Jin, J., Grim, J.E., Grim, J.A., Harper, J.W., Eisenman, R.N., Clurman, B.E. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  41. Identification of an N-terminal glycogen synthase kinase 3 phosphorylation site which regulates the functional localization of polycystin-2 in vivo and in vitro. Streets, A.J., Moon, D.J., Kane, M.E., Obara, T., Ong, A.C. Hum. Mol. Genet. (2006) [Pubmed]
  42. Cripto-1 induces phosphatidylinositol 3'-kinase-dependent phosphorylation of AKT and glycogen synthase kinase 3beta in human cervical carcinoma cells. Ebert, A.D., Wechselberger, C., Frank, S., Wallace-Jones, B., Seno, M., Martinez-Lacaci, I., Bianco, C., De Santis, M., Weitzel, H.K., Salomon, D.S. Cancer Res. (1999) [Pubmed]
  43. Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-catenin. Li, Y., Bharti, A., Chen, D., Gong, J., Kufe, D. Mol. Cell. Biol. (1998) [Pubmed]
  44. Wnt-1 but not epidermal growth factor induces beta-catenin/T-cell factor-dependent transcription in esophageal cancer cells. Mizushima, T., Nakagawa, H., Kamberov, Y.G., Wilder, E.L., Klein, P.S., Rustgi, A.K. Cancer Res. (2002) [Pubmed]
  45. Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells. Hajduch, E., Alessi, D.R., Hemmings, B.A., Hundal, H.S. Diabetes (1998) [Pubmed]
  46. Overexpression of NBS1 contributes to transformation through the activation of phosphatidylinositol 3-kinase/Akt. Chen, Y.C., Su, Y.N., Chou, P.C., Chiang, W.C., Chang, M.C., Wang, L.S., Teng, S.C., Wu, K.J. J. Biol. Chem. (2005) [Pubmed]
  47. Beta-parvin inhibits integrin-linked kinase signaling and is downregulated in breast cancer. Mongroo, P.S., Johnstone, C.N., Naruszewicz, I., Leung-Hagesteijn, C., Sung, R.K., Carnio, L., Rustgi, A.K., Hannigan, G.E. Oncogene (2004) [Pubmed]
  48. Hepatocyte growth factor suppresses acute renal inflammation by inhibition of endothelial E-selectin. Gong, R., Rifai, A., Dworkin, L.D. Kidney Int. (2006) [Pubmed]
  49. Effects of glycogen synthase kinase 3beta and cyclin-dependent kinase 5 inhibitors on morphine-induced analgesia and tolerance in rats. Parkitna, J.R., Obara, I., Wawrzczak-Bargiela, A., Makuch, W., Przewlocka, B., Przewlocki, R. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  50. Beta-secretase (BACE) and GSK-3 mRNA levels in Alzheimer's disease. Preece, P., Virley, D.J., Costandi, M., Coombes, R., Moss, S.J., Mudge, A.W., Jazin, E., Cairns, N.J. Brain Res. Mol. Brain Res. (2003) [Pubmed]
  51. Increased tau phosphorylation but absence of formation of neurofibrillary tangles in mice double transgenic for human tau and Alzheimer mutant (M146L) presenilin-1. Boutajangout, A., Leroy, K., Touchet, N., Authelet, M., Blanchard, V., Tremp, G., Pradier, L., Brion, J.P. Neurosci. Lett. (2002) [Pubmed]
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