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Gene Review

PTPRG  -  protein tyrosine phosphatase, receptor...

Homo sapiens

Synonyms: HPTPG, PTPG, Protein-tyrosine phosphatase gamma, R-PTP-GAMMA, R-PTP-gamma, ...
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Disease relevance of PTPRG


High impact information on PTPRG


Chemical compound and disease context of PTPRG


Biological context of PTPRG

  • Structure of the human receptor tyrosine phosphatase gamma gene (PTPRG) and relation to the familial RCC t(3;8) chromosome translocation [8].
  • Using seven microsatellite markers and four markers derived from a PTPRG YAC contig, we have further delineated the 3p14.2 region of LOH in RCCs [9].

Anatomical context of PTPRG


Associations of PTPRG with chemical compounds


Other interactions of PTPRG


Analytical, diagnostic and therapeutic context of PTPRG


  1. Epigenetic profiling of cutaneous T-cell lymphoma: promoter hypermethylation of multiple tumor suppressor genes including BCL7a, PTPRG, and p73. van Doorn, R., Zoutman, W.H., Dijkman, R., de Menezes, R.X., Commandeur, S., Mulder, A.A., van der Velden, P.A., Vermeer, M.H., Willemze, R., Yan, P.S., Huang, T.H., Tensen, C.P. J. Clin. Oncol. (2005) [Pubmed]
  2. The FHIT and PTPRG genes are deleted in benign proliferative breast disease associated with familial breast cancer and cytogenetic rearrangements of chromosome band 3p14. Panagopoulos, I., Pandis, N., Thelin, S., Petersson, C., Mertens, F., Borg, A., Kristoffersson, U., Mitelman, F., Aman, P. Cancer Res. (1996) [Pubmed]
  3. 17 beta-estradiol-regulated expression of protein tyrosine phosphatase gamma gene in cultured human normal breast and breast cancer cells. Zheng, J., Kulp, S.K., Zhang, Y., Sugimoto, Y., Dayton, M.A., Govindan, M.V., Brueggemeier, R.W., Lin, Y.C. Anticancer Res. (2000) [Pubmed]
  4. Receptor protein-tyrosine phosphatase gamma is a candidate tumor suppressor gene at human chromosome region 3p21. LaForgia, S., Morse, B., Levy, J., Barnea, G., Cannizzaro, L.A., Li, F., Nowell, P.C., Boghosian-Sell, L., Glick, J., Weston, A. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  5. Receptor-type protein tyrosine phosphatase gamma (PTP{gamma}), a new identifier for myeloid dendritic cells and specialized macrophages. Lissandrini, D., Vermi, W., Vezzalini, M., Sozzani, S., Facchetti, F., Bellone, G., Mafficini, A., Gentili, F., Ennas, M.G., Tecchio, C., Sorio, C. Blood (2006) [Pubmed]
  6. A MspI polymorphism and linkage mapping of the human protein-tyrosine phosphatase G (PTPRG) gene. Latif, F., Tory, K., Modi, W., Geil, L., LaForgia, S., Huebner, K., Zbar, B., Lerman, M.I. Hum. Mol. Genet. (1993) [Pubmed]
  7. Function analysis of estrogenically regulated protein tyrosine phosphatase gamma (PTPgamma) in human breast cancer cell line MCF-7. Liu, S., Sugimoto, Y., Sorio, C., Tecchio, C., Lin, Y.C. Oncogene (2004) [Pubmed]
  8. Structure of the human receptor tyrosine phosphatase gamma gene (PTPRG) and relation to the familial RCC t(3;8) chromosome translocation. Kastury, K., Ohta, M., Lasota, J., Moir, D., Dorman, T., LaForgia, S., Druck, T., Huebner, K. Genomics (1996) [Pubmed]
  9. Loss of heterozygosity at the familial RCC t(3;8) locus in most clear cell renal carcinomas. Druck, T., Kastury, K., Hadaczek, P., Podolski, J., Toloczko, A., Sikorski, A., Ohta, M., LaForgia, S., Lasota, J., McCue, P. Cancer Res. (1995) [Pubmed]
  10. Conjugated linoleic acid (CLA) up-regulates the estrogen-regulated cancer suppressor gene, protein tyrosine phosphatase gamma (PTPgama), in human breast cells. Wang, L.S., Huang, Y.W., Sugimoto, Y., Liu, S., Chang, H.L., Ye, W., Shu, S., Lin, Y.C. Anticancer Res. (2006) [Pubmed]
  11. Expression of transmembrane protein tyrosine phosphatase gamma (PTPgamma) in normal and neoplastic human tissues. Vezzalini, M., Mombello, A., Menestrina, F., Mafficini, A., Della Peruta, M., van Niekerk, C., Barbareschi, M., Scarpa, A., Sorio, C. Histopathology (2007) [Pubmed]
  12. Estrogenic down-regulation of protein tyrosine phosphatase gamma (PTP gamma) in human breast is associated with estrogen receptor alpha. Liu, S., Sugimoto, Y., Kulp, S.K., Jiang, J., Chang, H.L., Park, K.Y., Kashida, Y., Lin, Y.C. Anticancer Res. (2002) [Pubmed]
  13. Levels of expression of pleiotrophin and protein tyrosine phosphatase zeta are decreased in human colorectal cancers. Yamakawa, T., Kurosawa, N., Kadomatsu, K., Matsui, T., Itoh, K., Maeda, N., Noda, M., Muramatsu, T. Cancer Lett. (1999) [Pubmed]
  14. Chromosomal changes and progressive tumorigenesis of human bronchial epithelial cell lines. Ohnuki, Y., Reddel, R.R., Bates, S.E., Lehman, T.A., Lechner, J.F., Harris, C.C. Cancer Genet. Cytogenet. (1996) [Pubmed]
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