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Gene Review

PTPN12  -  protein tyrosine phosphatase, non-receptor...

Homo sapiens

Synonyms: PTP-PEST, PTPG1, Protein-tyrosine phosphatase G1, Tyrosine-protein phosphatase non-receptor type 12
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Disease relevance of PTPN12


High impact information on PTPN12


Biological context of PTPN12


Anatomical context of PTPN12

  • Finally, endogenous PTP-PEST and endogenous CAKbeta were found to localize to similar cellular compartments in epithelial and smooth muscle cells [8].
  • This exclusive association was observed in lysates from several cell lines and in transfected COS cells, but was not observed with other members of the PTP family, strongly suggesting that p130(cas) represents a major physiologically relevant substrate for PTP-PEST [9].
  • Thus, we propose that PTP-PEST, by a competition with the ligand of paxillin in the focal adhesion complex, could contribute to the removal of paxillin from the adhesion sites and consequently promote focal adhesion turnover [12].
  • When plated on fibronectin, PTP-PEST (-/-) fibroblasts display a strong defect in motility [7].
  • The protein tyrosine phosphatase PEST (PTP-PEST) is involved in the regulation of the actin cytoskeleton [13].

Associations of PTPN12 with chemical compounds


Physical interactions of PTPN12

  • Mutations in CD2BP1 disrupt binding to PTP PEST and are responsible for PAPA syndrome, an autoinflammatory disorder [15].

Enzymatic interactions of PTPN12

  • Mutation of proline 337 within this sequence to alanine significantly impairs the ability of PTP-PEST to recognise tyrosine phosphorylated p130cas as a substrate, without qualitatively affecting the selectivity of the interaction [16].

Regulatory relationships of PTPN12


Other interactions of PTPN12


Analytical, diagnostic and therapeutic context of PTPN12


  1. PTP-PEST: a protein tyrosine phosphatase regulated by serine phosphorylation. Garton, A.J., Tonks, N.K. EMBO J. (1994) [Pubmed]
  2. Cloning and expression of PTP-PEST. A novel, human, nontransmembrane protein tyrosine phosphatase. Yang, Q., Co, D., Sommercorn, J., Tonks, N.K. J. Biol. Chem. (1993) [Pubmed]
  3. Chromosomal localization of the protein tyrosine phosphatase G1 gene and characterization of the aberrant transcripts in human colon cancer cells. Takekawa, M., Itoh, F., Hinoda, Y., Adachi, M., Ariyama, T., Inazawa, J., Imai, K., Yachi, A. FEBS Lett. (1994) [Pubmed]
  4. Phosphorylation of a Wiscott-Aldrich Syndrome Protein-associated Signal Complex Is Critical in Osteoclast Bone Resorption. Chellaiah, M.A., Kuppuswamy, D., Lasky, L., Linder, S. J. Biol. Chem. (2007) [Pubmed]
  5. PTP-PEST phosphatase variations in human cancer. Streit, S., Ruhe, J.E., Knyazev, P., Knyazeva, T., Iacobelli, S., Peter, S., Hoefler, H., Ullrich, A. Cancer Genet. Cytogenet. (2006) [Pubmed]
  6. PTP-PEST, a scaffold protein tyrosine phosphatase, negatively regulates lymphocyte activation by targeting a unique set of substrates. Davidson, D., Veillette, A. EMBO J. (2001) [Pubmed]
  7. Protein tyrosine phosphatase-PEST regulates focal adhesion disassembly, migration, and cytokinesis in fibroblasts. Angers-Loustau, A., Côté, J.F., Charest, A., Dowbenko, D., Spencer, S., Lasky, L.A., Tremblay, M.L. J. Cell Biol. (1999) [Pubmed]
  8. Inhibition of the catalytic activity of cell adhesion kinase beta by protein-tyrosine phosphatase-PEST-mediated dephosphorylation. Lyons, P.D., Dunty, J.M., Schaefer, E.M., Schaller, M.D. J. Biol. Chem. (2001) [Pubmed]
  9. Identification of p130(cas) as a substrate for the cytosolic protein tyrosine phosphatase PTP-PEST. Garton, A.J., Flint, A.J., Tonks, N.K. Mol. Cell. Biol. (1996) [Pubmed]
  10. The noncatalytic domain of protein-tyrosine phosphatase-PEST targets paxillin for dephosphorylation in vivo. Shen, Y., Lyons, P., Cooley, M., Davidson, D., Veillette, A., Salgia, R., Griffin, J.D., Schaller, M.D. J. Biol. Chem. (2000) [Pubmed]
  11. Roles for the tubulin- and PTP-PEST-binding paxillin LIM domains in cell adhesion and motility. Brown, M.C., Turner, C.E. Int. J. Biochem. Cell Biol. (2002) [Pubmed]
  12. Intact LIM 3 and LIM 4 domains of paxillin are required for the association to a novel polyproline region (Pro 2) of protein-tyrosine phosphatase-PEST. Côté, J.F., Turner, C.E., Tremblay, M.L. J. Biol. Chem. (1999) [Pubmed]
  13. Caspase-3 regulates catalytic activity and scaffolding functions of the protein tyrosine phosphatase PEST, a novel modulator of the apoptotic response. Hallé, M., Liu, Y.C., Hardy, S., Théberge, J.F., Blanchetot, C., Bourdeau, A., Meng, T.C., Tremblay, M.L. Mol. Cell. Biol. (2007) [Pubmed]
  14. Paxillin is essential for PTP-PEST-dependent regulation of cell spreading and motility: a role for paxillin kinase linker. Jamieson, J.S., Tumbarello, D.A., Hallé, M., Brown, M.C., Tremblay, M.L., Turner, C.E. J. Cell. Sci. (2005) [Pubmed]
  15. Mutations in CD2BP1 disrupt binding to PTP PEST and are responsible for PAPA syndrome, an autoinflammatory disorder. Wise, C.A., Gillum, J.D., Seidman, C.E., Lindor, N.M., Veile, R., Bashiardes, S., Lovett, M. Hum. Mol. Genet. (2002) [Pubmed]
  16. Association of PTP-PEST with the SH3 domain of p130cas; a novel mechanism of protein tyrosine phosphatase substrate recognition. Garton, A.J., Burnham, M.R., Bouton, A.H., Tonks, N.K. Oncogene (1997) [Pubmed]
  17. PTP-PEST Couples Membrane Protrusion and Tail Retraction via VAV2 and p190RhoGAP. Sastry, S.K., Rajfur, Z., Liu, B.P., Cote, J.F., Tremblay, M.L., Burridge, K. J. Biol. Chem. (2006) [Pubmed]
  18. Effects of PPARgamma agonists on cell survival and focal adhesions in a Chinese thyroid carcinoma cell line. Chen, Y., Wang, S.M., Wu, J.C., Huang, S.H. J. Cell. Biochem. (2006) [Pubmed]
  19. Activators of protein kinase C stimulate association of Shc and the PEST tyrosine phosphatase. Habib, T., Herrera, R., Decker, S.J. J. Biol. Chem. (1994) [Pubmed]
  20. Cloning and characterization of a human cDNA encoding a novel putative cytoplasmic protein-tyrosine-phosphatase. Takekawa, M., Itoh, F., Hinoda, Y., Arimura, Y., Toyota, M., Sekiya, M., Adachi, M., Imai, K., Yachi, A. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
  21. Combination of gene targeting and substrate trapping to identify substrates of protein tyrosine phosphatases using PTP-PEST as a model. Côté, J.F., Charest, A., Wagner, J., Tremblay, M.L. Biochemistry (1998) [Pubmed]
  22. A MspI polymorphism and linkage mapping of the human protein-tyrosine phosphatase G (PTPRG) gene. Latif, F., Tory, K., Modi, W., Geil, L., LaForgia, S., Huebner, K., Zbar, B., Lerman, M.I. Hum. Mol. Genet. (1993) [Pubmed]
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