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Chemical Compound Review

AC1NSMSJ     (2E,4E)-octadeca-2,4-dienoic acid

Synonyms: CCRIS 7064, LMFA01030306, LS-164032, AKOS016009052, AK109425, ...
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Disease relevance of CCRIS 7064


Psychiatry related information on CCRIS 7064


High impact information on CCRIS 7064


Chemical compound and disease context of CCRIS 7064


Biological context of CCRIS 7064


Anatomical context of CCRIS 7064


Associations of CCRIS 7064 with other chemical compounds


Gene context of CCRIS 7064


Analytical, diagnostic and therapeutic context of CCRIS 7064


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  2. Diagnostic significance of octadeca-9,11-dienoic acid in cervical neoplasia. Green, A.J., Starkey, B.J., Halloran, S.P., McKee, G., Sutton, C.J., Manners, B.T., Walker, A.W. Lancet (1988) [Pubmed]
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  6. Decrease in linoleic acid metabolites as a potential mechanism in cancer risk reduction by conjugated linoleic acid. Banni, S., Angioni, E., Casu, V., Melis, M.P., Carta, G., Corongiu, F.P., Thompson, H., Ip, C. Carcinogenesis (1999) [Pubmed]
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  11. Conjugated linoleic acid suppresses NF-kappa B activation and IL-12 production in dendritic cells through ERK-mediated IL-10 induction. Loscher, C.E., Draper, E., Leavy, O., Kelleher, D., Mills, K.H., Roche, H.M. J. Immunol. (2005) [Pubmed]
  12. cis-9, trans-11 CLA derived endogenously from trans-11 18:1 reduces cancer risk in rats. Corl, B.A., Barbano, D.M., Bauman, D.E., Ip, C. J. Nutr. (2003) [Pubmed]
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  15. Isolation of a novel strain of Butyrivibrio fibrisolvens that isomerizes linoleic acid to conjugated linoleic acid without hydrogenation, and its utilization as a probiotic for animals. Fukuda, S., Suzuki, Y., Murai, M., Asanuma, N., Hino, T. J. Appl. Microbiol. (2006) [Pubmed]
  16. Conjugated linoleic acid-induced fatty liver can be attenuated by combination with docosahexaenoic acid in C57BL/6N mice. Yanagita, T., Wang, Y.M., Nagao, K., Ujino, Y., Inoue, N. J. Agric. Food Chem. (2005) [Pubmed]
  17. Conjugated linoleic acid promotes human adipocyte insulin resistance through NFkappaB-dependent cytokine production. Chung, S., Brown, J.M., Provo, J.N., Hopkins, R., McIntosh, M.K. J. Biol. Chem. (2005) [Pubmed]
  18. Interaction of fish oil and conjugated linoleic acid in affecting hepatic activity of lipogenic enzymes and gene expression in liver and adipose tissue. Ide, T. Diabetes (2005) [Pubmed]
  19. Effect of conjugated linoleic acid on body composition and plasma lipids in humans: an overview of the literature. Terpstra, A.H. Am. J. Clin. Nutr. (2004) [Pubmed]
  20. Conjugated linoleic acid supplementation, insulin sensitivity, and lipoprotein metabolism in patients with type 2 diabetes mellitus. Moloney, F., Yeow, T.P., Mullen, A., Nolan, J.J., Roche, H.M. Am. J. Clin. Nutr. (2004) [Pubmed]
  21. Conjugated linoleic acid induces human adipocyte delipidation: autocrine/paracrine regulation of MEK/ERK signaling by adipocytokines. Brown, J.M., Boysen, M.S., Chung, S., Fabiyi, O., Morrison, R.F., Mandrup, S., McIntosh, M.K. J. Biol. Chem. (2004) [Pubmed]
  22. Isomer-specific antidiabetic properties of conjugated linoleic acid. Improved glucose tolerance, skeletal muscle insulin action, and UCP-2 gene expression. Ryder, J.W., Portocarrero, C.P., Song, X.M., Cui, L., Yu, M., Combatsiaris, T., Galuska, D., Bauman, D.E., Barbano, D.M., Charron, M.J., Zierath, J.R., Houseknecht, K.L. Diabetes (2001) [Pubmed]
  23. Conjugated linoleic acid inhibits proliferation and induces apoptosis of normal rat mammary epithelial cells in primary culture. Ip, M.M., Masso-Welch, P.A., Shoemaker, S.F., Shea-Eaton, W.K., Ip, C. Exp. Cell Res. (1999) [Pubmed]
  24. PPARgamma-dependent effects of conjugated linoleic acid on the human glioblastoma cell line (ADF). Cimini, A., Cristiano, L., Colafarina, S., Benedetti, E., Di Loreto, S., Festuccia, C., Amicarelli, F., Canuto, R.A., Cerù, M.P. Int. J. Cancer (2005) [Pubmed]
  25. Conjugated linoleic acid isomers in mitochondria: evidence for an alteration of fatty acid oxidation. Demizieux, L., Degrace, P., Gresti, J., Loreau, O., Noël, J.P., Chardigny, J.M., Sébédio, J.L., Clouet, P. J. Lipid Res. (2002) [Pubmed]
  26. Dietary conjugated linoleic acids alter serum IGF-I and IGF binding protein concentrations and reduce bone formation in rats fed (n-6) or (n-3) fatty acids. Li, Y., Seifert, M.F., Ney, D.M., Grahn, M., Grant, A.L., Allen, K.G., Watkins, B.A. J. Bone Miner. Res. (1999) [Pubmed]
  27. Isomer-specific regulation of metabolism and PPARgamma signaling by CLA in human preadipocytes. Brown, J.M., Boysen, M.S., Jensen, S.S., Morrison, R.F., Storkson, J., Lea-Currie, R., Pariza, M., Mandrup, S., McIntosh, M.K. J. Lipid Res. (2003) [Pubmed]
  28. Conjugated linoleic acid and hepatic lipogenesis in mouse: role of the mitochondrial citrate carrier. Ferramosca, A., Savy, V., Conte, L., Colombo, S., Einerhand, A.W., Zara, V. J. Lipid Res. (2006) [Pubmed]
  29. Butter naturally enriched in conjugated linoleic acid and vaccenic acid alters tissue fatty acids and improves the plasma lipoprotein profile in cholesterol-fed hamsters. Lock, A.L., Horne, C.A., Bauman, D.E., Salter, A.M. J. Nutr. (2005) [Pubmed]
  30. The form of dietary conjugated linoleic acid does not influence plasma and liver triacylglycerol concentrations in Syrian golden hamsters. Porsgaard, T., Xu, X., Mu, H. J. Nutr. (2006) [Pubmed]
  31. Novel treatments for obesity and osteoporosis: targeting apoptotic pathways in adipocytes. Nelson-Dooley, C., Della-Fera, M.A., Hamrick, M., Baile, C.A. Current medicinal chemistry. (2005) [Pubmed]
  32. LXR-mediated activation of macrophage stearoyl-CoA desaturase generates unsaturated fatty acids that destabilize ABCA1. Wang, Y., Kurdi-Haidar, B., Oram, J.F. J. Lipid Res. (2004) [Pubmed]
  33. Maintenance of adiponectin attenuates insulin resistance induced by dietary conjugated linoleic acid in mice. Purushotham, A., Wendel, A.A., Liu, L.F., Belury, M.A. J. Lipid Res. (2007) [Pubmed]
  34. Inhibition of colon cancer cell proliferation by the dietary compound conjugated linoleic acid is mediated by the CDK inhibitor p21CIP1/WAF1. Lim, d.o. .Y., Tyner, A.L., Park, J.B., Lee, J.Y., Choi, Y.H., Park, J.H. J. Cell. Physiol. (2005) [Pubmed]
  35. Upregulation of liver VLDL receptor and FAT/CD36 expression in LDLR-/- apoB100/100 mice fed trans-10,cis-12 conjugated linoleic acid. Degrace, P., Moindrot, B., Mohamed, I., Gresti, J., Du, Z.Y., Chardigny, J.M., S??b??dio, J.L., Clouet, P. J. Lipid Res. (2006) [Pubmed]
  36. High-fat dairy food and conjugated linoleic acid intakes in relation to colorectal cancer incidence in the Swedish Mammography Cohort. Larsson, S.C., Bergkvist, L., Wolk, A. Am. J. Clin. Nutr. (2005) [Pubmed]
  37. Intake of conjugated linoleic acid, fat, and other fatty acids in relation to postmenopausal breast cancer: the Netherlands Cohort Study on Diet and Cancer. Voorrips, L.E., Brants, H.A., Kardinaal, A.F., Hiddink, G.J., van den Brandt, P.A., Goldbohm, R.A. Am. J. Clin. Nutr. (2002) [Pubmed]
  38. Cytochrome c catalyses the formation of pentyl radical and octanoic acid radical from linoleic acid hydroperoxide. Iwahashi, H., Nishizaki, K., Takagi, I. Biochem. J. (2002) [Pubmed]
  39. Exogenous conjugated linoleic acid isomers reduce bovine milk fat concentration and yield by inhibiting de novo fatty acid synthesis. Loor, J.J., Herbein, J.H. J. Nutr. (1998) [Pubmed]
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