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Gene Review

PTPRZ1  -  protein tyrosine phosphatase, receptor...

Homo sapiens

Synonyms: HPTPZ, HPTPzeta, HTPZP2, PTP-ZETA, PTP18, ...
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Disease relevance of PTPRZ1


High impact information on PTPRZ1


Chemical compound and disease context of PTPRZ1


Biological context of PTPRZ1


Anatomical context of PTPRZ1


Associations of PTPRZ1 with chemical compounds


Physical interactions of PTPRZ1


Regulatory relationships of PTPRZ1


Other interactions of PTPRZ1


Analytical, diagnostic and therapeutic context of PTPRZ1


  1. A critical role for the protein tyrosine phosphatase receptor type Z in functional recovery from demyelinating lesions. Harroch, S., Furtado, G.C., Brueck, W., Rosenbluth, J., Lafaille, J., Chao, M., Buxbaum, J.D., Schlessinger, J. Nat. Genet. (2002) [Pubmed]
  2. Differential induction of glioblastoma migration and growth by two forms of pleiotrophin. Lu, K.V., Jong, K.A., Kim, G.Y., Singh, J., Dia, E.Q., Yoshimoto, K., Wang, M.Y., Cloughesy, T.F., Nelson, S.F., Mischel, P.S. J. Biol. Chem. (2005) [Pubmed]
  3. The carbonic anhydrase domain of receptor tyrosine phosphatase beta is a functional ligand for the axonal cell recognition molecule contactin. Peles, E., Nativ, M., Campbell, P.L., Sakurai, T., Martinez, R., Lev, S., Clary, D.O., Schilling, J., Barnea, G., Plowman, G.D., Grumet, M., Schlessinger, J. Cell (1995) [Pubmed]
  4. A sodium channel signaling complex: modulation by associated receptor protein tyrosine phosphatase beta. Ratcliffe, C.F., Qu, Y., McCormick, K.A., Tibbs, V.C., Dixon, J.E., Scheuer, T., Catterall, W.A. Nat. Neurosci. (2000) [Pubmed]
  5. Multi-ligand interactions with receptor-like protein tyrosine phosphatase beta: implications for intercellular signaling. Peles, E., Schlessinger, J., Grumet, M. Trends Biochem. Sci. (1998) [Pubmed]
  6. Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine phosphatase beta. Sakurai, T., Lustig, M., Nativ, M., Hemperly, J.J., Schlessinger, J., Peles, E., Grumet, M. J. Cell Biol. (1997) [Pubmed]
  7. Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions. Peles, E., Nativ, M., Lustig, M., Grumet, M., Schilling, J., Martinez, R., Plowman, G.D., Schlessinger, J. EMBO J. (1997) [Pubmed]
  8. Cytotoxicity and recognition of receptor-like protein tyrosine phosphatases, RPTPalpha and RPTPbeta, by Helicobacter pylori m2VacA. De Guzman, B.B., Hisatsune, J., Nakayama, M., Yahiro, K., Wada, A., Yamasaki, E., Nishi, Y., Yamazaki, S., Azuma, T., Ito, Y., Ohtani, M., van der Wijk, T., den Hertog, J., Moss, J., Hirayama, T. Cell. Microbiol. (2005) [Pubmed]
  9. Functional comparison of long and short splice forms of RPTPbeta: implications for glioblastoma treatment. Lorente, G., Nelson, A., Mueller, S., Kuo, J., Urfer, R., Nikolich, K., Foehr, E.D. Neuro-oncology (2005) [Pubmed]
  10. No association of FOXP2 and PTPRZ1 on 7q31 with autism from the Japanese population. Marui, T., Koishi, S., Funatogawa, I., Yamamoto, K., Matsumoto, H., Hashimoto, O., Nanba, E., Kato, C., Ishijima, M., Watanabe, K., Kasai, K., Kato, N., Sasaki, T. Neurosci. Res. (2005) [Pubmed]
  11. Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta. Meng, K., Rodriguez-Peña, A., Dimitrov, T., Chen, W., Yamin, M., Noda, M., Deuel, T.F. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  12. Expression and function of the receptor protein tyrosine phosphatase zeta and its ligand pleiotrophin in human astrocytomas. Ulbricht, U., Brockmann, M.A., Aigner, A., Eckerich, C., Müller, S., Fillbrandt, R., Westphal, M., Lamszus, K. J. Neuropathol. Exp. Neurol. (2003) [Pubmed]
  13. RNA interference targeting protein tyrosine phosphatase zeta/receptor-type protein tyrosine phosphatase beta suppresses glioblastoma growth in vitro and in vivo. Ulbricht, U., Eckerich, C., Fillbrandt, R., Westphal, M., Lamszus, K. J. Neurochem. (2006) [Pubmed]
  14. Targeting of the receptor protein tyrosine phosphatase beta with a monoclonal antibody delays tumor growth in a glioblastoma model. Foehr, E.D., Lorente, G., Kuo, J., Ram, R., Nikolich, K., Urfer, R. Cancer Res. (2006) [Pubmed]
  15. Protein-tyrosine phosphatase alpha, RPTP alpha, is a Helicobacter pylori VacA receptor. Yahiro, K., Wada, A., Nakayama, M., Kimura, T., Ogushi, K., Niidome, T., Aoyagi, H., Yoshino, K., Yonezawa, K., Moss, J., Hirayama, T. J. Biol. Chem. (2003) [Pubmed]
  16. Characterization of heparin affin regulatory peptide signaling in human endothelial cells. Polykratis, A., Katsoris, P., Courty, J., Papadimitriou, E. J. Biol. Chem. (2005) [Pubmed]
  17. Brain-specific receptor-type protein-tyrosine phosphatase RPTP beta is a chondroitin sulfate proteoglycan in vivo. Shitara, K., Yamada, H., Watanabe, K., Shimonaka, M., Yamaguchi, Y. J. Biol. Chem. (1994) [Pubmed]
  18. Essential domain of receptor tyrosine phosphatase beta (RPTPbeta) for interaction with Helicobacter pylori vacuolating cytotoxin. Yahiro, K., Wada, A., Yamasaki, E., Nakayama, M., Nishi, Y., Hisatsune, J., Morinaga, N., Sap, J., Noda, M., Moss, J., Hirayama, T. J. Biol. Chem. (2004) [Pubmed]
  19. Glial tumor cell adhesion is mediated by binding of the FNIII domain of receptor protein tyrosine phosphatase beta (RPTPbeta) to tenascin C. Adamsky, K., Schilling, J., Garwood, J., Faissner, A., Peles, E. Oncogene (2001) [Pubmed]
  20. Junctional protein MAGI-3 interacts with receptor tyrosine phosphatase beta (RPTP beta) and tyrosine-phosphorylated proteins. Adamsky, K., Arnold, K., Sabanay, H., Peles, E. J. Cell. Sci. (2003) [Pubmed]
  21. Receptor tyrosine phosphatase beta (RPTPbeta) activity and signaling are attenuated by glycosylation and subsequent cell surface galectin-1 binding. Abbott, K.L., Matthews, R.T., Pierce, M. J. Biol. Chem. (2008) [Pubmed]
  22. Differential gene up-regulation by hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha in HEK293T cells. Wang, V., Davis, D.A., Haque, M., Huang, L.E., Yarchoan, R. Cancer Res. (2005) [Pubmed]
  23. The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system. Levy, J.B., Canoll, P.D., Silvennoinen, O., Barnea, G., Morse, B., Honegger, A.M., Huang, J.T., Cannizzaro, L.A., Park, S.H., Druck, T. J. Biol. Chem. (1993) [Pubmed]
  24. Increased expression of midkine in the rat colon during healing of experimental colitis. Yuki, T., Ishihara, S., Rumi, M.A., Ortega-Cava, C.F., Kadowaki, Y., Kazumori, H., Ishimura, N., Amano, Y., Moriyama, N., Kinoshita, Y. Am. J. Physiol. Gastrointest. Liver Physiol. (2006) [Pubmed]
  25. Assignment of the human protein tyrosine phosphatase, receptor-type, zeta (PTPRZ) gene to chromosome band 7q31.3. Ariyama, T., Hasegawa, K., Inazawa, J., Mizuno, K., Ogimoto, M., Katagiri, T., Yakura, H. Cytogenet. Cell Genet. (1995) [Pubmed]
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