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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Breast Diseases

 
 
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Disease relevance of Breast Diseases

 

High impact information on Breast Diseases

 

Chemical compound and disease context of Breast Diseases

  • Estrogen replacement therapy and benign breast disease [10].
  • We concluded that oral contraceptives reduced the incidence of benign breast disease, but that use of steroid hormones is ill-advised for women with already established benign breast disease [11].
  • Because cholesterol 5,6-epoxides have been reported to be mutagenic, carcinogenic, and cytotoxic, we investigated the relationship of these substances in breast fluid to histopathologically defined breast disease [12].
  • PURPOSE: Gemcitabine has promising single-agent activity in advanced breast disease [13].
  • This elevation in phosphocreatine plus a parallel elevation in an uncharacterized phosphate resonating at a chemical shift of 3.66 delta permits the important differentiation between malignancy and benignancy in human breast disease [14].
 

Biological context of Breast Diseases

 

Anatomical context of Breast Diseases

 

Gene context of Breast Diseases

  • Specifically and more directly, an association was also observed between the presence of a PTEN mutation and malignant breast disease [25].
  • In conclusion, TP53 gene mutation of the primary tumor is helpful in predicting the response of patients with metastatic breast disease to tamoxifen therapy [26].
  • Thrombospondin and other possible related matrix proteins in malignant and benign breast disease. An immunohistochemical study [27].
  • Together these experiments indicate that TGFalpha and the EGFR signaling pathway are potentially amenable to therapies for treatment of human breast disease [28].
  • Our data demonstrate that KDR activation is enhanced in breast cancer in vivo and emphasize the functional role of VEGF and KDR in the development of malignant breast disease [29].
 

Analytical, diagnostic and therapeutic context of Breast Diseases

  • Enzyme immunoassays were developed with the new antibodies and evaluated for their ability to discriminate between sera from breast cancer patients and from controls with benign breast disease [30].
  • We have used the MCF10AT xenograft model of human proliferative breast disease to examine the early effects of estradiol exposure on morphological progression of preneoplastic lesions and to define the step(s) in the morphological sequence at which estrogen may act [31].
  • The relation between methylxanthine consumption and biopsied benign breast disease was investigated by using data from a case-control study which included 1,569 cases and 1,846 controls identified between 1973 and 1980 through a nationwide screening program [32].
  • The percentage of free oestradiol was found to be highest in women with breast cancer, lowest in the control group and intermediate for the women with benign breast disease [33].
  • METHODS AND RESULTS: The present study addresses this issue by using cytokeratin 19 mRNA detection by reverse transcription-polymerase chain reaction (RT-PCR) in preoperative and postoperative blood samples from 54 patients undergoing excisional biopsy for benign breast disease; 22 healthy volunteers represented the control group [34].

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