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FAM60A  -  family with sequence similarity 60, member A

Homo sapiens

Synonyms: C12orf14, L4, Protein FAM60A, TERA, Tera protein homolog
 
 
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Disease relevance of FAM60A

  • Activation of the early-late switch in adenovirus type 5 major late transcription unit expression by L4 gene products [1].
  • Mutation of L4 ribosomal protein conferring unusual macrolide resistance in two independent clinical isolates of Staphylococcus aureus [2].
 

High impact information on FAM60A

  • In the absence of an inducer, the synthesis of I7 was repressed, proteolytic processing of the A17 membrane protein and the L4 core protein was inhibited, and virus morphogenesis was blocked [3].
  • One is oriented rightward, contained within the intron in the protein-coding region for the L4 33K gene, and would encode a protein sharing N-terminal sequence with 33K [4].
  • To allow for only viral DNA replication resulted in an extensive premature transcription termination and a preferential mRNA accumulation from regions L1 and L4 [5].
  • The surprising production of L4 mRNA under these conditions was not due to the activation of a novel r-strand promoter located in the vicinity of region L4 or due to a control at the level of RNA transport or stability [5].
  • Three isolates displayed mutations in the gene encoding the L4 ribosomal protein that is part of the exit tunnel within the 50S subunit of the bacterial ribosome [6].
 

Biological context of FAM60A

  • Ro60 has also been shown to participate in the regulation of the translational fate of the L4 ribosomal protein mRNA by interacting with the 5' untranslated region, again suggesting its possible implication in ribosome biogenesis [7].
 

Anatomical context of FAM60A

  • From a kinetical point of view, subtilisin-treated L4 phosphofructokinase and leukocyte enzymes are characterized by a decrease of the allosteric properties as compared to non-treated red cell L4 phosphofructokinase [8].
  • Whisker deprivation weakens excitatory layer 4 (L4) inputs to L2/3 pyramidal cells in rat primary somatosensory (S1) cortex, which is likely to contribute to whisker map plasticity [9].
  • On images showing the lower margin of the L-4 vertebra, the anatomy in 182 patients (81%) was classified as Type A because the inferior vena cava (IVC) was not bifurcated; in 38 patients (17%) it was classified as Type B because the IVC was bifurcated [10].
  • A mild treatment of red blood cell L4 enzyme with subtilisin converts its subunits into forms of similar molecular weight to leukocyte enzyme [8].
 

Associations of FAM60A with chemical compounds

  • Susceptibilities to telithromycin and six other agents and prevalence of macrolide resistance due to L4 ribosomal protein mutation among 992 Pneumococci from 10 central and Eastern European countries [11].
  • Among erythromycin-resistant S. pneumoniae isolates, strains harboring erm(B) genes (125 strains [69.4%]) were found to be predominant over strains with mef(E) genes (25 strains [13.4%]), L4 protein mutations (28 strains [15.6%]), and erm(A) genes (2 strains [1.1%]) [11].
  • 5. L4 pyruvate kinase is more inhibited by Mg-ATP than L4', with L2L2' in the intermediate range [12].
  • 4. L4' enzyme exhibits Michaelis-Menten kinetic behaviour with an apparent Michaelis constant of 3.8 mM whereas L4 enzyme shows both positive and negative homotropic interactions towards phosphoenolpyruvate and has [S] 0.5 of 1.2 mM [12].
 

Analytical, diagnostic and therapeutic context of FAM60A

  • Six strains which showed negative results for mef(A) and erm(B) in repeated PCR assays had mutations in 23S rRNA or alterations in the L4 ribosomal protein (two strains) [13].
  • Similar pulsed-field gel electrophoresis patterns suggested that some strains containing L4 mutations from the Slovak Republic, Bulgaria, and Latvia were clonally related [11].
  • The anti-XL3 surface protein serum was stage specific in immunofluorescence experiments using live worms and in immunoprecipitation experiments using 125Iodine-labeled XL3 and L4 surface proteins [14].
  • The control group conversely demonstrated a predilection for disc degeneration at L4/5 level [15].

References

  1. Activation of the early-late switch in adenovirus type 5 major late transcription unit expression by L4 gene products. Farley, D.C., Brown, J.L., Leppard, K.N. J. Virol. (2004) [Pubmed]
  2. Mutation of L4 ribosomal protein conferring unusual macrolide resistance in two independent clinical isolates of Staphylococcus aureus. Prunier, A.L., Trong, H.N., Tande, D., Segond, C., Leclercq, R. Microb. Drug Resist. (2005) [Pubmed]
  3. Role of the I7 protein in proteolytic processing of vaccinia virus membrane and core components. Ansarah-Sobrinho, C., Moss, B. J. Virol. (2004) [Pubmed]
  4. The DNA sequence of adenovirus type 40. Davison, A.J., Telford, E.A., Watson, M.S., McBride, K., Mautner, V. J. Mol. Biol. (1993) [Pubmed]
  5. Control of adenovirus major late gene expression at multiple levels. Larsson, S., Svensson, C., Akusjärvi, G. J. Mol. Biol. (1992) [Pubmed]
  6. Emergence of group A streptococcus strains with different mechanisms of macrolide resistance. Bingen, E., Leclercq, R., Fitoussi, F., Brahimi, N., Malbruny, B., Deforche, D., Cohen, R. Antimicrob. Agents Chemother. (2002) [Pubmed]
  7. Assessing the function of the Ro ribonucleoprotein complex using Caenorhabditis elegans as a biological tool. Labbé, J.C., Hekimi, S., Rokeach, L.A. Biochem. Cell Biol. (1999) [Pubmed]
  8. Partial proteolysis of human L-type phosphofructokinase. Lagrange, J.L., Meienhofer, M.C., Kahn, A. Enzyme (1981) [Pubmed]
  9. Synaptic basis for whisker deprivation-induced synaptic depression in rat somatosensory cortex. Bender, K.J., Allen, C.B., Bender, V.A., Feldman, D.E. J. Neurosci. (2006) [Pubmed]
  10. An evaluation of vascular anatomy for minilaparotomic anterior L4-5 procedures. Kang, U.U., Lee, S.H., Jeon, S.H., Park, J.D., Maeng, D.H., Choi, Y.G., Tsang, Y.S. Journal of neurosurgery. Spine (2006) [Pubmed]
  11. Susceptibilities to telithromycin and six other agents and prevalence of macrolide resistance due to L4 ribosomal protein mutation among 992 Pneumococci from 10 central and Eastern European countries. Nagai, K., Appelbaum, P.C., Davies, T.A., Kelly, L.M., Hoellman, D.B., Andrasevic, A.T., Drukalska, L., Hryniewicz, W., Jacobs, M.R., Kolman, J., Miciuleviciene, J., Pana, M., Setchanova, L., Thege, M.K., Hupkova, H., Trupl, J., Urbaskova, P. Antimicrob. Agents Chemother. (2002) [Pubmed]
  12. The genetic system of the L-type pyruvate kinase forms in man. Subunit structure, interrelation and kinetic characteristics of the pyruvate kinase enzymes from erythrocytes and liver. Kahn, A., Marie, J., Garreau, H., Sprengers, E.D. Biochim. Biophys. Acta (1978) [Pubmed]
  13. Antimicrobial susceptibility of Streptococcus pneumoniae in eight European countries from 2001 to 2003. Reinert, R.R., Reinert, S., van der Linden, M., Cil, M.Y., Al-Lahham, A., Appelbaum, P. Antimicrob. Agents Chemother. (2005) [Pubmed]
  14. Haemonchus contortus: a simple procedure for purifying surface proteins from third- and fourth-stage larvae. Cox, G.N., Shamansky, L.M., Boisvenue, R.J. Exp. Parasitol. (1990) [Pubmed]
  15. Degenerative disc disease as a cause of back pain in the thalassaemic population: a case-control study using MRI and plain radiographs. Desigan, S., Hall-Craggs, M.A., Ho, C.P., Eliahoo, J., Porter, J.B. Skeletal Radiol. (2006) [Pubmed]
 
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