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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

Muc3  -  mucin 3

Mus musculus

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Disease relevance of Muc3

 

High impact information on Muc3

  • Conclusions: The Muc3 mucin cysteine-rich domain plays an active role in epithelial restitution, and represents a potential novel therapeutic agent for intestinal wound healing [5].
  • Soluble form of T cell Ig mucin 3 is an inhibitory molecule in T cell-mediated immune response [6].
  • No evidence was obtained for the existence of soluble splice variants; however, experiments with heterologous cells transfected with cDNA encoding the 381-residue C-terminal domain of rodent Muc3 showed that a definitive proteolytic cleavage occurs during processing in the endoplasmic reticulum [7].
  • Human mucin MUC3 and rodent Muc3 are widely assumed to represent secretory mucins expressed in columnar and goblet cells of the intestine [3].
  • Two antibodies specific for COOH-terminal epitopes of Muc3 localized to apical membranes and cytoplasm of columnar cells [3].
 

Biological context of Muc3

  • These data indicate that cytokines and growth factors are capable of regulating Muc3 gene expression, suggesting that this protein may play an active role in intestinal mucosal defense [8].
  • The first two exons of Muc3 are separated by an intron of over 8 kb [8].
  • Characterization of the mouse Muc3 membrane bound intestinal mucin 5' coding and promoter regions: regulation by inflammatory cytokines [8].
 

Anatomical context of Muc3

  • We demonstrate by PCR confirmation of microarray data and by avidin blotting of immunoprecipitated human Mucin 3 (MUC3), that surface MUC3 expression is induced in T84 intestinal epithelial cells following exposure to hypoxia [1].
  • Thus Muc3 is expressed in two forms, a full-length membrane-associated form found in columnar cells (light density) and a carboxyl-truncated soluble form present in goblet cells (heavy density) [3].
 

Associations of Muc3 with chemical compounds

  • The mouse Muc3 mucin is a membrane-bound glycoprotein highly expressed in the intestinal tract [8].
 

Analytical, diagnostic and therapeutic context of Muc3

References

  1. Selective induction of mucin-3 by hypoxia in intestinal epithelia. Louis, N.A., Hamilton, K.E., Canny, G., Shekels, L.L., Ho, S.B., Colgan, S.P. J. Cell. Biochem. (2006) [Pubmed]
  2. MUC genes are differently expressed during onset and maintenance of inflammation in dextran sodium sulfate-treated mice. Hoebler, C., Gaudier, E., De Coppet, P., Rival, M., Cherbut, C. Dig. Dis. Sci. (2006) [Pubmed]
  3. Characteristics of rodent intestinal mucin Muc3 and alterations in a mouse model of human cystic fibrosis. Khatri, I.A., Ho, C., Specian, R.D., Forstner, J.F. Am. J. Physiol. Gastrointest. Liver Physiol. (2001) [Pubmed]
  4. Cutting edge: T cell Ig mucin-3 reduces inflammatory heart disease by increasing CTLA-4 during innate immunity. Frisancho-Kiss, S., Nyland, J.F., Davis, S.E., Barrett, M.A., Gatewood, S.J., Njoku, D.B., Cihakova, D., Silbergeld, E.K., Rose, N.R., Fairweather, D. J. Immunol. (2006) [Pubmed]
  5. Cysteine-rich domains of muc3 intestinal mucin promote cell migration, inhibit apoptosis, and accelerate wound healing. Ho, S.B., Dvorak, L.A., Moor, R.E., Jacobson, A.C., Frey, M.R., Corredor, J., Polk, D.B., Shekels, L.L. Gastroenterology (2006) [Pubmed]
  6. Soluble form of T cell Ig mucin 3 is an inhibitory molecule in T cell-mediated immune response. Geng, H., Zhang, G.M., Li, D., Zhang, H., Yuan, Y., Zhu, H.G., Xiao, H., Han, L.F., Feng, Z.H. J. Immunol. (2006) [Pubmed]
  7. C-terminal domain of rodent intestinal mucin Muc3 is proteolytically cleaved in the endoplasmic reticulum to generate extracellular and membrane components. Wang, R., Khatri, I.A., Forstner, J.F. Biochem. J. (2002) [Pubmed]
  8. Characterization of the mouse Muc3 membrane bound intestinal mucin 5' coding and promoter regions: regulation by inflammatory cytokines. Shekels, L.L., Ho, S.B. Biochim. Biophys. Acta (2003) [Pubmed]
  9. Coordinated Muc2 and Muc3 mucin gene expression in Trichinella spiralis infection in wild-type and cytokine-deficient mice. Shekels, L.L., Anway, R.E., Lin, J., Kennedy, M.W., Garside, P., Lawrence, C.E., Ho, S.B. Dig. Dis. Sci. (2001) [Pubmed]
 
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