Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

PRSS22 - protease, serine, 22

Homo sapiens

Synonyms: BSSP-4, BSSP4, Brain-specific serine protease 4, PRSS26, SP001LA, ...

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of PRSS22

Selection of some of the most suitable mRNAs (TMEM69, RANBP3 and PRSS22) that were assayed in blood samples from normal subjects and patients with colon cancer as possible markers for the presence of epithelial cells in the blood, using reverse transcription-polymerase chain reaction (RT-PCR) [1].

High impact information on PRSS22

Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase epsilon/PRSS22 [2].
The ability to activate uPA in the presence of varied protease inhibitors suggests that tryptase epsilon plays a prominent role in fibrinolysis and other uPA-dependent reactions in the lung [2].
Recombinant pro-tryptase epsilon was generated to understand how the exocytosed zymogen might be activated outside of the epithelial cell, as well as to address its possible role in normal and diseased states [2].
Tryptase epsilon is a member of the chromosome 16p13.3 family of human serine proteases that is preferentially expressed by epithelial cells [2].
Tryptase epsilon also was able to induce pro-uPA-expressing smooth muscle cells to increase their migration through a basement membrane-like extracellular matrix [2].

Biological context of PRSS22

Probing of the GenBank expressed sequence tag (EST) data base with varied human tryptase cDNAs identified two truncated ESTs that subsequently were found to encode overlapping portions of a novel human serine protease (designated tryptase epsilon or protease, serine S1 family member 22 (PRSS22)) [3].
In vitro studies revealed that recombinant tryptase epsilon possesses a restricted substrate specificity [2].

Anatomical context of PRSS22

The trachea and esophagus were found to contain the highest steady-state levels of the tryptase epsilon transcript in adult humans [3].

Associations of PRSS22 with chemical compounds

Thus, the tryptase epsilon gene is expressed in the airways in a developmentally regulated manner that is different from that of other human tryptase genes [3].

References

Microarray-based identification and RT-PCR test screening for epithelial-specific mRNAs in peripheral blood of patients with colon cancer. Solmi, R., Ugolini, G., Rosati, G., Zanotti, S., Lauriola, M., Montroni, I., del Governatore, M., Caira, A., Taffurelli, M., Santini, D., Coppola, D., Guidotti, L., Carinci, P., Strippoli, P. BMC Cancer (2006) [Pubmed]
Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase epsilon/PRSS22. Yasuda, S., Morokawa, N., Wong, G.W., Rossi, A., Madhusudhan, M.S., Sali, A., Askew, Y.S., Adachi, R., Silverman, G.A., Krilis, S.A., Stevens, R.L. Blood (2005) [Pubmed]
Human tryptase epsilon (PRSS22), a new member of the chromosome 16p13.3 family of human serine proteases expressed in airway epithelial cells. Wong, G.W., Yasuda, S., Madhusudhan, M.S., Li, L., Yang, Y., Krilis, S.A., Sali, A., Stevens, R.L. J. Biol. Chem. (2001) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

PRSS22	Bos taurus
PRSS22	Canis lupus familiaris
CG8170	Drosophila melanogaster
Prss22	Mus musculus
PRSS22	Pan troglodytes
Prss22	Rattus norvegicus

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.