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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SMOC1  -  SPARC related modular calcium binding 1

Homo sapiens

Synonyms: SMOC-1, SPARC-related modular calcium-binding protein 1, Secreted modular calcium-binding protein 1
 
 
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High impact information on SMOC1

  • Immunogold electron microscopy confirmed the localization of SMOC-1 within basement membranes in kidney and skeletal muscle as well as its expression in the zona pellucida surrounding the oocyte [1].
  • Recombinant expression in human cells showed that SMOC-1 is a glycoprotein with a calcium-dependent conformation [1].
  • Analysis of various compounds from different suppliers yielded delta37Cl values for chlorate samples near to +0.2/1000 (SMOC), but one has within-sample heterogeneity of 0.5/1000, possibly due to crystallization processes during manufacture [2].
  • Results for perchlorate samples also are generally near +0.2/1000, but one is +2.3/1000 (SMOC) [2].
  • The evidence supporting the identity of this channel as the channel involved in SMOC generation was its sensitivity to internal Ca(2+), external TEA, and caffeine [3].
 

Anatomical context of SMOC1

  • Characterization of SMOC-1, a novel modular calcium-binding protein in basement membranes [1].
  • Real-time PCR showed maximum expression of AKL, LRRN6A, and T-cell receptor gamma (TCR-gamma)-like genes in the testis, SMOC-1 in the liver, and the T-cell receptor-like (TCRL) gene in the spleen compared to those used as endogenous control [4].
 

Associations of SMOC1 with chemical compounds

  • After SMOCs were completely inhibited by BAPTA, 3 mM caffeine caused SMOC activity to resume [5].
  • EGTA-AM (10 microM) caused no inhibition of SMOC activation, whereas 10 microM BAPTA-AM consistently inhibited SMOCs [5].
  • SMOC frequency is decreased in solutions that contain 0 Ca(2+)/3.6 mM Mg(2+), and also in the presence of 1 microM nifedipine and 3 microM omega-conotoxin GVIA, suggesting that SMOC activation is dependent on calcium influx [5].
 

Analytical, diagnostic and therapeutic context of SMOC1

References

  1. Characterization of SMOC-1, a novel modular calcium-binding protein in basement membranes. Vannahme, C., Smyth, N., Miosge, N., Gösling, S., Frie, C., Paulsson, M., Maurer, P., Hartmann, U. J. Biol. Chem. (2002) [Pubmed]
  2. Methods for the stable isotopic analysis of chlorine in chlorate and perchlorate compounds. Ader, M., Coleman, M.L., Doyle, S.P., Stroud, M., Wakelin, D. Anal. Chem. (2001) [Pubmed]
  3. Number of K(Ca) channels underlying spontaneous miniature outward currents (SMOCs) in mudpuppy cardiac neurons. Scornik, F.S., Merriam, L.A., Parsons, R.L. J. Neurophysiol. (2001) [Pubmed]
  4. Transcriptional status of known and novel genes tagged with consensus of 33.15 repeat loci employing minisatellite-associated sequence amplification (MASA) and real-time PCR in water buffalo, Bubalus bubalis. Srivastava, J., Premi, S., Pathak, D., Ahsan, Z., Tiwari, M., Garg, L.C., Ali, S. DNA Cell Biol. (2006) [Pubmed]
  5. Ca(2+)-induced Ca(2+) release activates spontaneous miniature outward currents (SMOCs) in parasympathetic cardiac neurons. Merriam, L.A., Scornik, F.S., Parsons, R.L. J. Neurophysiol. (1999) [Pubmed]
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