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Gene Review

Lum  -  lumican

Rattus norvegicus

Synonyms: KSPG lumican, Keratan sulfate proteoglycan lumican, Lcn, Ldc, Lumican
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Disease relevance of Lum

  • After L-arginine injection, an immature fibrosis with fragmented and loose collagen fibers was observed in AP on day 4 and lumican immunoreactivity was detected in the collagen fibers [1].
  • In the present study, we aim to clarify whether lumican mRNA and its protein are expressed in exocrine or endocrine components in acute pancreatitis (AP) [1].
  • We previously found that lumican mRNA and its protein were ectopically and highly expressed in acinar cells in chronic pancreatitis (CP)-like lesions close to pancreatic cancer cells [1].

High impact information on Lum


Chemical compound and disease context of Lum


Biological context of Lum

  • Recently, lumican mRNA was found in the heart and its high expression was reported during wound healing of the cornea [3].

Anatomical context of Lum


Associations of Lum with chemical compounds

  • Western blot analysis showed an intense 50-kDa band corresponding to the lumican protein in normal and L-arginine-treated rat pancreas [1].
  • Lumican is a member of a small leucine-rich proteoglycan family [1].
  • Comparisons of glycosaminoglycan and proteoglycan label allowed extrapolations to be made as to likely glycosaminoglycan components of the large proteoglycans, and of other proteoglycans that may be present - thus differential distribution of aggrecan and keratan sulfate label suggested the presence of fibromodulin and/or lumican [4].

Analytical, diagnostic and therapeutic context of Lum


  1. Transient and ectopic expression of lumican by acinar cells in L-arginine-induced acute pancreatitis. Naito, Z., Ishiwata, T., Lu, Y.P., Teduka, K., Fujii, T., Kawahara, K., Sugisaki, Y. Exp. Mol. Pathol. (2003) [Pubmed]
  2. Effects of the extracellular matrix on lumican expression in rat aortic smooth muscle cells in vitro. Qin, H., Ishiwata, T., Asano, G. J. Pathol. (2001) [Pubmed]
  3. Expression and localization of lumican in the ischemic and reperfused rat heart. Baba, H., Ishiwata, T., Takashi, E., Xu, G., Asano, G. Jpn. Circ. J. (2001) [Pubmed]
  4. Extracellular matrix in development of the intervertebral disc. Hayes, A.J., Benjamin, M., Ralphs, J.R. Matrix Biol. (2001) [Pubmed]
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