Disease relevance of Lum

• After L-arginine injection, an immature fibrosis with fragmented and loose collagen fibers was observed in AP on day 4 and lumican immunoreactivity was detected in the collagen fibers [1].
• In the present study, we aim to clarify whether lumican mRNA and its protein are expressed in exocrine or endocrine components in acute pancreatitis (AP) [1].
• We previously found that lumican mRNA and its protein were ectopically and highly expressed in acinar cells in chronic pancreatitis (CP)-like lesions close to pancreatic cancer cells [1].

High impact information on Lum

• These results show that lumican was synthesized in cultured rat aortic SMCs as proteoglycan, glycoprotein, and core protein [2].
• The relationships of lumican to fibronectin and laminin were also investigated [2].
• Effects of the extracellular matrix on lumican expression in rat aortic smooth muscle cells in vitro [2].
• Whether lumican is localized in rat aortic smooth muscle cells (SMCs) and what its relationships might be to other extracellular matrix components have not yet been elucidated [2].
• Lumican is a small leucine-rich proteoglycan (SLRP), which contributes to cell migration, proliferation, tissue hydration, and collagen fibrillogenesis [2].

Chemical compound and disease context of Lum

• Transient and ectopic expression of lumican by acinar cells in L-arginine-induced acute pancreatitis [1].

Biological context of Lum

• Recently, lumican mRNA was found in the heart and its high expression was reported during wound healing of the cornea [3].

Anatomical context of Lum

• However, the expression and role of lumican in acute inflammatory changes of the pancreas are not completely elucidated [1].
• These findings indicate that lumican is transiently synthesized by acinar cells and fibroblasts in AP [1].
• Lumican mRNA was faintly detected in islet cells in the normal pancreas, but it was strongly expressed in acinar and islet cells on day 1 [1].
• In the control heart, lumican was weakly expressed in the collagen fibers of the perivascular area, but it was expressed strongly in many capillary endothelial cells in the ischemic lesion on day 1 [3].

Associations of Lum with chemical compounds

• Western blot analysis showed an intense 50-kDa band corresponding to the lumican protein in normal and L-arginine-treated rat pancreas [1].
• Lumican is a member of a small leucine-rich proteoglycan family [1].
• Comparisons of glycosaminoglycan and proteoglycan label allowed extrapolations to be made as to likely glycosaminoglycan components of the large proteoglycans, and of other proteoglycans that may be present - thus differential distribution of aggrecan and keratan sulfate label suggested the presence of fibromodulin and/or lumican [4].

Analytical, diagnostic and therapeutic context of Lum

• Furthermore, lumican mRNA was expressed in many proliferating fibroblasts on day 4 by in situ hybridization [1].
• In this study, using reverse transcription-polymerase chain reaction (RT-PCR), competitive RT-PCR, and western blot, lumican messenger ribonucleic acid (mRNA) was expressed in cultured rat aortic SMCs [2].

References